Jobs

Postdoctoral Fellow, Stevens Lab

Employer

The Broad Institute of MIT and Harvard

Location

Cambridge, Massachusetts

Principal Investigator

Beth Stevens

Contact

akane@broadinstitute.org

Description

This position is for immediate availability.

The Stevens lab is looking for a motivated and energetic postdoctoral associate to join the neurobiology group at the Stanley Center for Psychiatric Research. This is an exciting opportunity to collaboratively develop and engage in cutting-edge research into neuroimmune interactions, mechanisms of synapse development, and their impact on neurodegenerative disorders.

The Stevens lab uses animal and cell culture model systems to understand the development and disruption of synapses in the cerebral cortex at a molecular level, and to investigate how disease genetic risk variants disrupt this process. The lab collaborates closely with neurobiology, genetics, stem cells, and therapeutics teams throughout the Stanley Center, as well as other groups at Broad. This position will be charged specifically with leading a funded project looking at how aging and genetic risk for Alzheimer's disease interact to affect human iPSC-derived microglia using a variety of cell culture assays and molecular biology techniques.

The candidate should possess a Ph.D. in molecular or cell biology or a related field, with prior research experience in neurodegeneration, high-throughput genomics techniques, and cell and tissue culture models, as well as familiarity with the background and concepts of common polygenic disease risk.

Characteristic Duties

  • Work collaboratively across labs and groups to design and execute experiments key to the project’s successful outcome.
  • Consult the literature, supervisor, and other scientific staff as needed to troubleshoot experiments.
  • Prepare and maintain mouse and human cell cultures, including induced pluripotent stem cells (iPSC).
  • Perform advanced microscopy and image analysis, including on high-content imaging systems.
  • Present progress to collaborators and consortium members as well as at conferences, and publish results.
  • Maintain detailed experimental records, documentation, and written protocols.

Requirements

  • Ph.D. in neuroscience or a related field, with specific experience researching the molecular and cellular mechanisms of neurodegenerative diseases.
  • Excellent communication, organization, and time management skills.
  • High level of initiative and motivation; ability to work independently and with a team.
  • Ability to think creatively to solve problems.
  • Curiosity to learn new things and a passion to make a difference in the lives of patients by advancing the science of neurological disease.