Jobs

Postdoctoral Fellow in Proteomics and Blood Biomarkers – Suárez-Calvet Lab

Employer

Barcelonaβeta Brain Research Center Foundation (BBRC)

Location

Barcelona, Spain

Principal Investigator

Marc Suárez-Calvet

Contact

Please send curriculum vitae, cover letter describing research interests and relevant background and contact information for three reference to: rh@barcelobabeta.org.

More information: https://www.barcelonabeta.org/en/bbrc-research-center/job-offers.

Description

Barcelonaβeta is looking for a highly motivated postdoctoral researcher to join its team and work in the ERC grant-funded HeBe project. The postdoc will work in the new BBRC lab under the supervision of Marc Suárez-Calvet.

The postdoc's main duty will be to perform the mass spectrometry proteomics analyses of blood samples of the HeBe project. In collaboration with the proteomics unit at PRBB (led by Eduard Sabidó), the postdoc researcher will analyze the plasma samples of the ALFA cohort in order to discover blood factors that have a rejuvenating and aging effect in the brain. The postdoc will take the lead in this part of the HeBe project, and will be in charge of the experimental design, proteomics experiments, data collection and analysis, write-up and dissemination of the results (publications, talks, and posters).

The postdoc will also collaborate with the clinical metabolomics platform at IMIM-Hospital del Mar (led by Óscar Pozo) to measure metabolites in the ALFA plasma samples. Additionally, the postdoc will coordinate a collaboration with OLink using the ALFA blood samples. The postdoc will eventually analyze all the proteomic and metabolomic data with the support of a data scientist.

The Postdoc will be encouraged to join the team's ongoing projects, focused on the measurements of fluid biomarkers in the preclinical stage of Alzheimer’s disease. The lab will be equipped with state-of-the-art platforms, including Simoa and MSD instruments.

The postdoc will also be given the opportunity to investigate research questions that drive their curiosity. He/she will be expected to become increasingly autonomous over the course of time in the lab, and supervise junior team members. The postdoc will receive the mentorship needed to pursue his or her own scientific career. Funding to attend international scientific meetings will be provided.

The post will be funded for three years in the first instance. The start date for the position is September 2021, but negotiable +/- a few months.

Responsibilities

  • Lead the proteomic studies of the HeBe project, including experimental design, sample preparation (blood), and analysis by means of mass spectrometry and bioinformatics to identify and quantify proteins.
  • Participate and coordinate the metabolomic and OLink studies.
  • Perform basic biochemistry techniques (e.g. ELISA, western blot, immunoprecipitation) and biomarker analyses with ultrasensitive assays (Simoa, MSD platforms) in human samples (CSF, blood).
  • Assist with the instructing and training of students, fellows, technicians and laboratory assistants as required.
  • Prepare and publish high-quality scholarly papers, contributing to the academic environment of the laboratory and institute. Participate in applications for competitive research funding support.
  • Participate in regular internal meetings and internal as well as external collaborations.

Requirements

Must have

  • A Ph.D. degree (or will hold in autumn 2021) in biological and/or chemical sciences (e.g. biochemistry, molecular and cell biology, biomedicine, medical chemistry, neuroscience, analytical chemistry, or similar).
  • Previous experience and technical expertise in proteomics, mass spectrometry and similar techniques. Candidates with a track record in using proteomics for the discovery of disease biomarkers in blood and/or the study of neurological diseases are strongly encouraged to apply.
  • Previous experience in a biochemistry lab.
  • Strong statistics and data analyses skills. A high priority will be given to candidates with competence in generating, analyzing, and publishing "big data."
  • A solid publication record with first-author research publication(s) in peer-reviewed international journals.
  • Excellent communication and writing skills in English.
  • Able to work both independently and collaboratively.
  • A high level of motivation, drive, initiative and enthusiasm.

Desirable but not required/ Nice to have

  • Experience in Alzheimer’s disease or other neurodegenerative diseases research.
  • Experience in biomarker analyses.
  • Experience in metabolomics.
  • Experience in Proximal Extension Analyses (Olink) assays.
  • Experience in supervising undergraduate students, leadership roles.