Postdoctoral Fellow Position to Study TDP-43 Proteinopathy in Alzheimer’s Disease and Related Disorders


University of Kentucky/ Sanders-Brown Center on Aging


Lexington, Kentucky

Principal Investigator

Maj-Linda Selenica



Selenica’s laboratory is currently looking for highly skilled and motivated molecular and cell biologists to be the drivers of efforts to unravel mechanisms contributing to the TDP-43 pathology of limbic-predominant age-related TDP-43 encephalopathy (LATE) and Alzheimer’s Disease Related Dementias (ADRD). Core areas of focus will be understanding the role of novel PTMs in TDP-43 protein structure, biology, and pathology both in vitro (induced pluripotent stem cell models) and in vivo systems (mouse models). Our lab focuses on the molecular, cellular, and tissue-level mechanisms by which these various PTMs and the associated enzymes modulate disease risk. The candidate will join a multidisciplinary and highly collaborative research team that includes geneticists, immunologists, biostatisticians, neuroscientists, and neuropathologist at the Sanders-Brown Center on Aging as one of the leading centers in the country for ADRD and LATE research and clinical interventions.


  • Ph.D. in biology, neuroscience, or related field with deep expertise in molecular and cellular biology techniques.
  • Strong research experience in human iPSC technology and targeted genome editing in vitro (preferred) – or – in high-throughput technologies single-cell transcriptomics, epigenomics, lipidomics and/or proteomics (preferred) – or – in functional genomics (e.g., siRNA, shRNA, CRISPR/Cas9) screens (preferred).
  • Strong research experience in establishing, modifying, and optimizing techniques related to the areas of neuroscience, inflammation, and disordered proteins.
  • Expertise in high throughput imaging techniques including but not limited to confocal, electron microscopy, FRAP, 2P imaging.
  • Strong research experience in small animal surgery, AAV methods, etc., is highly preferred.
  • Knowledge of experimental design.
  • Statistical and quantitative analysis skills.
  • Basic bioinformatics skills (preferred).
  • Self-motivated and highly dedicated.
  • Effective organizational and prioritization skills.
  • Strong writing skills evident in published work and efficient grantsmanship skills.
  • Effective oral, written, and interpersonal communication skills.
  • Ability to work both independently and collaboratively in a multidisciplinary environment.