Postdoctoral fellow – Neuronal and vascular contributions to Alzheimer Disease


University College London


London, England, United Kingdom

Principal Investigator

Marc Aurel Busche


To apply please see:


The Busche lab is seeking an exceptional individual who will head an industry-funded (Eisai) research project focused at uncovering the long-term effects of Alzheimer’s disease pathology on neuronal circuit and vascular functions in the intact brain in vivo, how such effects relate to to behavioral deficits in mouse models of the disease, and determining whether pathophysiology is reversible. The project will involve recording neuronal activity and vascular dynamics using head-mounted miniscopes and/or fiber photometry in freely behaving mouse models, manipulating circuits with opto- or chemogenetics, and integration of these techniques with behavioral testing and a variety of sophisticated interventions.

The Busche lab is a highly interactive environment, with strong collaborations within the UK DRI as well as collaborators both at UCL and other renowned institutions.The successful candidate will be self-directed with excellent research skills, capable of working collaboratively in a team of researchers, while maintaining independent thinking and initiative. This is an outstanding opportunity to work independently on a high-impact, state-of-the-art project in a stimulating and social international research environment. In particular, the post-holder will have the unique opportunity to work in close collaboration with scientists at Eisai, one of the world’s leading global research and development-based pharmaceutical companies, founded in 1941 and headquartered in Japan.

The post is available immediately and funded by a UK DRI grant in collaboration with Eisai for three years in the first instance.