Postdoctoral Fellow – Molecular Mechanism of Tau Pathogenesis


University of California, San Diego


San Diego , California

Principal Investigator

Xu Chen


Please send curriculum vitae and contact information for three references to:

Xu Chen, Ph.D., Dept. of Neurosciences, UCSD, 9500 Gilman Drive, La Jolla, CA 92093-0612; e-mail:


The Neurodegenerative Disease Research Laboratory at UC San Diego is recruiting a postdoctoral researcher to join its team dedicated to unravelling the mechanisms of neurotoxicity in Alzheimer's disease and related dementia (tauopathies). The lab uses iPSC-derived neurons, primary neurons, brain slice culture, state-of-the-art molecular and biochemistry techniques, gene therapy, mouse and fly models to investigate the molecular basis for neuronal degeneration, with a focus on the metabolic signaling, endo-lysosomal pathway, autophagy, inflammation, and synaptic excitotoxicity.

The lab's researchers also study how protein aggregates spread from cell-to-cell within the brain. They are looking for highly motivated candidates to lead projects including the impact of metabolic pathways on endolysosomal function and tau-mediated neurotoxicity. The salary is above NIH scale and the benefits are excellent.

NIH-funded projects include understanding the mechanisms of tau accumulation and spread between cells, how metabolic signaling pathways modulate tau pathogenesis, and mechanisms underlying tau-mediated neurotoxicity. The Chen Laboratory is highly interactive with collaborators at UCSD and outside institutes.

Additional information can be found at


Candidates with research experience in neuroscience, cell biology, biochemistry, and/or molecular biology, as well as mouse genetics and excellent communication skills, are encouraged to apply. The successful candidates will conduct both independent and collaborative research within a productive scientific lab group. The candidates are also encouraged to explore new research areas and seek independent funding as part of their own career development.

A Ph.D./M.D. with research experience in neuroscience, cell biology, biochemistry, molecular biology or related fields is required. Preferred (but not required) to have experience with mouse and/or fly genetics, iPSC, neuronal and glial culture. Excellent work ethic.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or disability.