Postdoctoral Fellow – Microglia-neuron interactions in vivo


University College London


London, England, United Kingdom

Principal Investigator

Marc Aurel Busche



The Busche lab ( is seeking an exceptional individual who will lead an industry-funded (Roche) research project focused at uncovering how microglia and neurons interact in Alzheimer’s disease in vivo, and that will apply novel approaches to determine whether pathophysiology is reversible. The project will involve recording neuronal activity and microglia dynamics using state-of-the-art two-photon imaging and/or patch-clamp electrophysiology in mouse models, and applying cutting-edge single cell transcriptomic methods.

The Busche lab is a highly interactive environment, with strong collaborations across the U.K. DRI as well as with researchers at UCL and other renowned institutions. The successful candidate will be self-directed, with excellent research skills, and capable of working collaboratively within a team of international multidisciplinary researchers while displaying independent thinking and initiative. This is an outstanding opportunity to work independently on a high-impact, state-of-the-art project in a stimulating, vibrant research environment. In particular, the post-holder will have the unique opportunity to work in close collaboration with scientists at Roche, one of the world’s leading global research-and-development-based pharmaceutical companies, and to spend some time at their headquarters in Basel, Switzerland.


For more information and to apply, please visit