Jobs

Postdoctoral fellow, Genomic Neurosciences

Employer

Van Andel Institute

Location

Grand Rapids, Michigan

Principal Investigator

Rita Guerreiro

Contact

Qualified applicants should provide a cover letter outlining research experience and interests, a curriculum vitae, and the names and contact details of three references to Profs. Darren Moore, Rita Guerreiro, and José Brás.

Description

Van Andel Institute is looking for a highly motivated and collaborative postdoctoral fellow to work on a project being jointly developed by the laboratories of Profs. Darren Moore, Rita Guerreiro, and José Brás, in the Center for Neurodegenerative Science at the Van Andel Institute in Michigan.

The position is available for an ambitious scientist to use or establish biochemical, cellular and structural models to investigate the pathogenic mechanisms underlying ATP13A2 mutations in neurodegenerative diseases with a special focus on Spastic Paraplegia 78.

The laboratories employ a multidisciplinary approach involving human genomics and numerous experimental model systems, including primary neurons, C. elegans, Drosophila and rodents, to elucidate the biological function and pathophysiological mechanisms of proteins linked to inherited forms of neurodegenerative diseases. For this project the lab is particularly interested in the development of induced pluripotent stem cell (IPSC) models and the use of CRISPR/Cas9 to characterize cellular phenotypes associated with patient-derived mutations.

Please visit the websites for an overview of our research and labs: https://moorelab.vai.org/; https://guerreirolab.vai.org/; https://braslab.vai.org/.

Job Functions:

Van Andel Institute (VAI) provides postdoctoral training opportunities to scientists beginning their research careers. The fellowships are to help promising scientists advance their knowledge and research experience and at the same time support the research endeavors of VAI under the mentorship of a VAI Faculty member. While this project is currently funded, an integral part of postdoctoral training is the process of preparing a research proposal and writing a fellowship application. All VAI Postdoctoral Fellows are encouraged to apply for external funding as soon as it is practical and reasonable after hire. Receiving a fellowship award provides recognition for both the fellow and VAI.

VAI is actively striving to diversify its workforce and strongly encourages qualified individuals from underrepresented groups to apply. Van Andel Institute is an EEO and Affirmative Action Employer

Requirements

Qualifications:

  • A recent Ph.D. with demonstrated experience in any of the following fields: cell biology, biochemistry, and/or neuroscience.  At least one publication in these fields would be desirable.
  • A preferred candidate will have experience in any of the following research areas: IPSC-derived neuronal culture models; confocal and/or stereological microscopy; viral vector technology; development of genetic animal models; single-cell sequencing; molecular/cellular neurobiology; structural biology (Cryo-EM).

Description of a Successful Candidate:

  • A self-motivated and driven individual who is able to exhibit exceptional research productivity and take responsibility for independent management of a project.
  • A detail-oriented researcher who still keeps a clear grasp of the big picture.
  • A team player who proactively shares knowledge and expertise with lab members.
  • Excellent written and oral communication skills.