Jobs

Postdoctoral Fellow – Gene Therapy for AD

Employer

Baylor College of Medicine

Location

Houston, Texas

Principal Investigator

Joanna Jankowsky

Contact

To apply, please send a CV and contact information for three references to:  jankowsk@bcm.edu

For more information about the laboratory: https://www.bcm.edu/research/labs/joanna-jankowsky

Description

The Jankowsky lab at Baylor College of Medicine seeks a postdoctoral fellow for an NIH-funded project developing gene therapy for proteinopathies. 

The lab has identified peptide variants that prevent and reverse amyloid formation. By vectorizing these peptides for viral delivery into the brain, researchers can reduce plaque pathology in mouse models of AD. The lab now wants to examine how dosing, route, and timing influence efficacy, with particular emphasis on identifying treatments that remain effective after disease onset. Future studies will apply the same strategy against tau by identifying sequence variants that prevent aggregation and can be vectorized for viral delivery.  

The lab seeks motivated candidates who are intellectually and experimentally flexible. Researchers will work as part of a team combining protein biochemistry, viral engineering, neurohistology, and transcriptomics to push the boundaries of the lab's current amyloid gene therapy and explore new vectors against tau.

Requirements

  • Applicants should hold (or soon receive) a Ph.D. in neuroscience or a related discipline. 
  • Successful applicants should be highly self-motivated, have outstanding organizational skills, and be able to think independently but also work well in a team. Applicants will join a highly collaborative laboratory in a much larger neuroscience community. 
  • Experience with genetically engineered mouse models is preferred but not required.
  • Expertise in a broad range of molecular, biochemical, and cell biological techniques is desired, including Western blotting, ELISA, cloning, cell culture, transfection, and immunofluorescence.
  • Strong oral and written communication skills.  
  • Creativity and inquisitiveness to follow wherever the science leads.
  • Priority will be given to candidates with no or short (<three years) prior postdoctoral experience.