Postdoctoral Fellow in Functional Analysis of Alzheimer Disease Candidate Genes


Washington University School of Medicine


St. Louis, Missouri

Principal Investigator

Carlos Cruchaga


A postdoctoral research fellow position is available immediately at the Cruchaga lab at the Washington University School of Medicine. The lab is part of the Hope Center for Neurological Disorders, which fosters knowledge-sharing and collaboration among many different research groups that study a range of nervous system diseases with the common feature of neurodegeneration or death of nerve cells. The team is focused in understanding the biology of Alzheimer's disease, Parkinson's disease, and other neurodegerative diseases by combining genetics and functional genomic approaches. Recent studies from this lab and others have identified novel genes associated with AD, such as TREM2, PLD3, CPAMD8, or ABCA7 between others. The lab aims to explore the role of these genes in the pathogenesis of Alzheimer's disease using a variety of cell systems from both animal models and human lines: immortalize and primary lines as well as iPSC.

The successful candidate will join an interdisciplinary team and will be expected to perform functional analysis for the evaluation of the candidate genes, in collaboration with other teams with expertise in of iPSC and animal models.

The position is initially restricted to the evaluation of a defined set of candidate genes, but there are many opportunities to initiate projects that contribute to our understanding of the molecular and cellular mechanisms underlying Alzheimer disease. It is expected that the selected applicant will be involved in the design and execution of experiments to tackle the project objectives; involvement in general tasks related to the lab work routine; active participation in periodic laboratory meetings; manuscript preparation and publishing; presentation of work in international conferences.

This position is offered initially one to two years with a maximum of five years. There is flexibility over starting dates, but successful applicants are welcome to take up post starting September 1, 2018. Salary and benefits will follow the NIH pay scale.


Candidates should hold a Ph.D. in cell biology, biochemistry, or related areas, ideally with a focus on neuroscience or related human field.

The applicant should have expertise in cellular cultures, Webster-blot, ELISA, direct-site mutagenesis, PCR, and q-PCR, between others. Knowledge of genome-editing techniques and iPSC cultures is desirable.