Postdoctoral Fellow


University of California, San Francisco – the Institute for Neurodegenerative Diseases


San Francisco, California

Principal Investigator

 Dan Southworth and Stanley Prusiner


Interested applicants should contact Dr. Southworth and provide a brief cover letter, a CV, and contact info for three references.


Postdoctoral positions in cryoEM are available in the Southworth Lab at the Institute for Neurodegenerative Diseases (IND), University of California, San Francisco. Research projects involve interdisciplinary and collaborative efforts across the Dan Southworth, David Agard, and Stanley Prusiner labs, supported by an NIH Program Project grant to study the structural basis of amyloid/prion propagation in neurodegenerative diseases. Project focus areas include:

  • Development of cryo-EM affinity-grid technologies for structure determination of amyloid filaments.
  •  Determining the structural basis of tau, Aβ, and synuclein prion propagation.
  •  Characterization of filament ultrastructure in cells by CLEM and FIB-SEM tomography.

The IND cryoEM resources at the UCSF Mission Bay campus include a Titan Krios with phase plate, energy filter, and Gatan K3, a 200 keV Glacios with a Gatan K2, and a Talos L120C. As a part of UCSF Center for Advanced CryoEM, additional state-of-the-art cryoEM resources are available, including a Titan Krios, Glacios and Talos Arctica as well as a FIB-SEM facility scheduled to be operational later this year. The appointee will have opportunities to present work and interact routinely with IND investigators and cryoEM community across UCSF and the Bay Area.

UC San Francisco seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to its commitment to diversity and excellence.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.


The qualified candidate should have a Ph.D. with expertise in biochemistry and structural biology, including cryoEM and/or crystallography.