Jobs

Postdoctoral Fellow

Employer

Johns Hopkins University

Location

Baltimore, Maryland

Principal Investigator

Shuying Sun

Contact

Interested candidates should provide a cover letter (with statement of research interest and career goals), CV, and the contact information for three references to Shuying Sun at shuying.sun@jhmi.edu.

Description

Postdoctoral opportunities are available in Shuying Sun’s laboratory at Johns Hopkins University School of Medicine. The lab will explore the fascinating frontiers of RNA metabolism dysfunction and RNA-targeting therapy in neurodegenerative diseases by combining molecular and cellular approaches, genome editing, proteomic, genomic, and screening platforms.

The nervous system has extremely complex RNA processing regulation and dysfunction of RNA metabolism has emerged to play crucial roles in multiple neurological diseases. Mutations and pathologies of several RNA-binding proteins are found to be associated with neurodegeneration in both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). An alternative RNA-mediated toxicity arises from microsatellite repeat instability in the human genome. The expanded repeat-containing RNAs could potentially induce neuron toxicity by disrupting protein and RNA homeostasis through various mechanisms.

The Sun lab is interested in deciphering the molecular mechanisms of disease pathogenesis and seeks to translate the mechanistic findings to therapeutic target development to advance treatment options against neurodegenerative diseases. Please visit the lab website for additional information.

Requirements

We are looking for highly motivated postdoc fellows with solid PhD training in biochemistry, molecular and cellular biology. Experiences with RNA biology, neuroscience or bioinformatics are preferred but not limited to. You will join a strong and highly interactive science community at Johns Hopkins.