Jobs

Postdoc: Molecular Mechanisms of ALS/FTD

Employer

Ludwig-Maximillians-University

Location

Munich, Germany

Principal Investigator

Dorothee Dormann

Contact

Please forward applications, including motivation letter, CV, and contact information of at least two referees, via email to Dorothee Dormann (dorothee.dormann@med.uni-muenchen.de)

Description

Postdoc position is available to study the molecular mechanisms of neurodegenerative diseases, in particular the role of RNA-binding proteins (RBPs) in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The aim is to understand the molecular defects that cause mislocalization and aggregation of the RBPs TDP-43 and FUS in ALS and FTD patients by studying how nucleocytoplasmic transport and aggregation of TDP-43 and FUS are normally regulated and how they are misregulated in disease.

The Dormann lab uses cellular and in vitro models and a variety of cell biological/biochemical methods, such as nuclear transport assays, protein/RNA biochemistry, phase separation/aggregation assays and fluorescence microscopy, including life cell imaging. The research also entails many collaborations with other researchers locally, nationally and internationally.

Requirements

The lab seeks a highly motivated postdoctoral researcher with a Ph.D. degree in the field of biosciences and a strong background in biochemistry/cell biology, ideally with experience in neuronal cell models (e.g. stem cell/iPSC-derived neurons or organotypic slice cultures) or RNA biochemistry or mass spectrometry.