Ph.D. Student for a Project About Retinal ASS and Tau Pathology in AD
Posted 22 Dec 2020
SuQin Venema, Laboratory of Neuropathology
The lab wants to determine the prevalence and topographical pattern of Aβ and p-τ pathology in the retina of elderly individuals and AD patients using immunohistochemistry.
Immunohistochemical and biochemical analysis will clarify whether APPxτ-transgenic mice will have more p-τ and /or Aβ pathology than the respective single transgenic mice. The lab wants to test whether Aβ and p-τ seeds injected into the subretinal zone induce or accelerate Aβ or p-τ pathology in the brain regions to which the optic nerve projects.
- The successful candidate will do animal experiments with transgenic mice (eye injections).
- The successful candidate will do Immunohistochemical and imunofluorescence stainings and analysis of human and mouse eyes samples.
- The successful candidate will pathologically analyze mouse and human eyes.
- The successful candidate will supervise lab rotation students and master students.
- International exchange in the course of the project is considered.
- The successful candidate will report your data to your supervisors, other researchers, as well at (international) conferences.
The offer includes
- Financing for four years (financed by Stichting Alzheimer Onderzoek (three years).
- Promotion of PhD-thesis to be written within the four years.
- Participation in an individually shaped Ph.D. Program.
- Presentation of valuable findings at international conferences.
The candidate should be experienced in the following techniques:
- Sample preparation for biochemical analysis
- Western blot analysis
- PCR analysis
- Working with lab animals
What we are looking for:
- Candidates should have a Master's degree according to EU standards.
- Candidates should meet the English language criteria of KU Leuven.
- Candidates should have FELASA B certificate for carrying out animal experiments (if not we expect that you follow the FELASA B course within the first three months).
- Candidates should be willing to work with patient tissue and conduct animal experiments.
- Highly motivated, enthusiastic, critical and creative.
- The ability to work in a team.
- Willingness to participate in an international exchange program for one year of the Ph.D.