Ph.D. Position on Imaging of the Medial Temporal Lobe in Aging and Dementia
Posted 04 May 2020
For more details, contact information, and applying, see https://lu.varbi.com/en/what:job/jobID:331266.
As the world population is aging, dementia and age-related brain changes and cognitive impairments are becoming an increasingly important research topic. An important brain region to study in this context is the medial temporal lobe (MTL). The MTL is a highly complex structure, made up of cytoarchitectonically and functionally different subregions, which subserve different cognitive functions and are hypothesized to be differentially vulnerable to different neurodegenerative pathologies.
This project therefore focuses on the MTL in the context of aging and disease. MRI will be used to identify structural and functional changes, and PET imaging to identify tau and amyloid pathology. The objectives of this project are 1) to contribute to the development of fine-grained and sensitive methods to measure volume loss in MTL subregions, 2) to characterize changes in the MTL in aging populations related to different types of dementias and to normal aging.
By studying fine-grained subregions in the MTL, the researchers hope to gain a better understanding of underlying disease mechanisms, but also potentially develop biomarkers to track disease progression in dementia and for clinical trials.
The primary site for this project will be the Clinical Memory Research Unit and the Swedish BioFINDER Study Group, both headed by Professor Oskar Hansson. This group has world-class expertise in neurodegenerative diseases, fluid biomarkers and molecular imaging. The Swedish BioFINDER Study aims to discover key mechanisms in Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative disorders for the development of early and accurate diagnostic tests, identification of novel treatment targets, and understanding the links between different pathologies and clinical symptoms. The Swedish BioFINDER Study has become a world-leading cohort unique for its detailed characterization of amyloid and tau pathologies using state-of-the-art PET and ultra-high resolution MRI scans for the measurements of medial temporal lobe subregions. This study has led to more than 100 original research papers in the last four years, many of which in high impact journal such as Nature Medicine, JAMA and Brain.
The following are required for the position:
- Master's of science, or a foreign qualification deemed equivalent, within medicine, biomedical science, psychology, neuroscience, or a related field
- Proficiency in oral and written communication in English.
- Strong communication, presentation, and writing skills.
- Patience, attention to detail, precision, the ability to work independently, and good collaborative skills.
The following are considered to be a merit:
- Experience with MRI.
- Specific interest in dementia and aging.