Ph.D. to develop clinically viable brain delivery technologies for biologicals
Posted 03 May 2019
VIB-KU Leuven Center for Brain & Disease Research
Leuven , Belgium
Please complete the online application procedure and include a detailed CV, a short motivation letter describing previous research experience and the names and contact information of three references. Interested candidates are invited to apply as soon as possible. Applications will be welcome until the position is filled.
For more information: please contact Bart De Strooper, or go to http://www.vib.be/en/research/scientists/Pages/Bart-De-Strooper-Lab.aspx.
The De Strooper lab's project is to identify, through a highly innovative and challenging in vivo screening platform, novel RMT receptors with higher capacity and/or safety and/or specificity profile. Due to the smart design of the platform, this study will also identify VHHs (Nanobodies®, single-chain antibody fragments originating from camelids) able to cross the BBB through these receptors. The major goals of this highly translational project are:
- to generate a therapeutic drug candidate for cancer brain metastasis in the next three years;
- to develop medication for neurodegenerative diseases such as Alzheimer's disease;
- getting proof-of-concept for our in vivo screening platform;
- found a spin-off company around the technology and gen rated drug candidates.
The current blood-brain-barrier team in the lab comprises four researchers and is supported by two major local grants (SBO (FWO) and Grand Challenges (VIB)), and some other funding resources (FWO scholarship and Cure AD fund). The team has ongoing intense collaborations with multiple national and international academic partners and companies. The collaboration (and funding) is coordinated from within the De Strooper lab.
To strengthen their team, they are looking for a dynamic and ambitious scientist with a keen interest in applied and translational research.
- Innovative and creative personality.
- Ability to independently generate precise, reliable data and interpret them.
- Master's degree with (at least) distinction in one of the following fields: biochemistry, molecular biology, neurosciences or a related field..
- Fluency in English (verbally and in writing) is mandatory.
- Highly motivated to work in an international competitive environment.
- Love for scientific work.
Desirable but not required
- Understanding of and hands on experience with the blood brain barrier.
- Experience with some standard cell biology (mammalian cell culture, FACS, immunofluorescence …) and molecular biology techniques (cloning, protein expression and purification.
- Experience with assay development (ELISA, AlphaScreen, cell-based screens, reporter assays …).
- Experience with in vivo models.
- Experience in antibody development.
- Experience in protein engineering and/or affinity maturation methods.
- Experience with phage display.