Experienced Researcher (f/m/d) Nutrition, Lifestyle and Brain Health


German Center for Neurodegenerative Diseases (DZNE)


Bonn, Germany

Principal Investigator

Antonio Schmandke



DZNE aims to understand the complex and heterogeneous causes of neurodegenerative and other age-related diseases in order to contribute to their effective, individualized prevention and treatment. Specifically, it investigates the interplay between the genome and the exposome in determining health status. An important focus is on interactions and mutual dependencies between mechanisms involved in immunology and inflammation, aging, and metabolic programming, and the central nervous system. The research is mostly based on the Rhineland Study, a deeply phenotyped population-based cohort that will include more than 20,000 people aged 30 years and older and is designed to run for decades. Core data collection includes extensive structural and functional brain imaging, cognitive and behavioral assessments, cardiovascular investigations, sensory systems assessments, questions on medical history, medication intake, lifestyle, nutrition and mental health, and extensive collection of biomaterials. To this end, DZNE recently added immunophenotyping through cell profiling in several flow cytometry panels and whole blood stimulation assays with a range of innate immune stimuli.


The successful candidate is expected to lead and further develop research efforts in this area. Responsibilities include but are not limited to:

  • Supervision of data acquisition (immunophenotyping, immune activation, cytokine and transcriptome analysis).
  • Analysis of data and preparation of manuscripts for publication in peer-reviewed journals.
  • Supervision of graduate students.
  • Maintaining contact with our internal and external academic partners.
  • Preparation of grant applications to strengthen line of research and to develop own research focus.

The position offers interesting and challenging work on the forefront of health research in a highly interdisciplinary and international team; participation in the Bonn-based Cluster of Excellence “Immunosensation2” as well as several international consortia; great opportunities for groundbreaking research collaborations; and a high potential for the development of the researcher's own profile. The DZNE actively encourages and supports employees’ personal development and growth.

Employment, payment and social benefits are determined by the Public Sector Collective Agreement (Tarifvertrag für den öffentlichen Dienst–TvöD).

The professional qualification of early career researchers is of great importance for DZNE. Besides special offers for career development and support, the DZNE also provides researchers career opportunities in form of junior research groups or internal career paths to obtain scientific independence.


Candidates should have a Ph.D. in immunology, epidemiology, medicine, computational biology, or other relevant discipline, and experience in the field of complex disease research. Demonstrated interest in quantitative research, strong analytical skills, ability for independent and critical thinking, leadership capabilities, and excellent communication and writing skills in the English language are prerequisites. Working experience in epidemiological research or large-scale observational studies as well as experience in clinical immunology are highly desirable.