Experienced Researcher (f/m/d) Integrative Multi-omics


German Center for Neurodegenerative Diseases (DZNE)


Bonn, Germany

Principal Investigator

Antonio Schmandke


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DZNE aims to understand the complex and heterogeneous causes of neurodegenerative and other age-related diseases in order to contribute to their effective, individualized prevention and treatment. Specifically, it investigates the interplay between the genome and the exposome in determining health status. The research is based on the Rhineland Study, a population-based cohort that will include more than 20,000 people aged 30 years and older and is designed to run for decades.

The Rhineland Study emphasizes deep phenotyping. Besides detailed clinical data, the DZNE collects extensive -omics information from all participants, including genomic, epigenomic, transcriptomic, metabolomic, proteomic as well as microbiomic data. These multi-omics data are of critical importance to most of DZNE's ongoing as well as future research projects, which aim to identify and understand the molecular and biochemical pathways that mediate the effects of various risk factors on brain structure and function.

The researcher will be responsible for the management and further development of the multi-omics platform of the Rhineland Study. He or she will be supported by a bioinformatician and a team of young scientists working on various aspects of the omic analyses, and will play a key role in many of the groups' research projects. In addition, the researcher will have the opportunity to develop and lead his or her own research line as it fits within the general research interests of the Schmandke group.


  • Processing and analyzing multi-scale omics data (including genotyping arrays, DNA/RNA sequencing and metabolomics data).
  • Supervision of graduate students.
  • Analysis of data and preparation of manuscripts for publication in peer-reviewed journals.
  • Maintaining contacts and active collaborations with internal and external academic and industrial partners.
  • Preparation of grant applications.

The position offers interesting and challenging work on the forefront of health research; working in a highly interdisciplinary and international team; and a high potential for the development of the researcher's own profile.

The position is initially for two years, extension possible. The common language at work is English.

Employment, payment and social benefits are determined by the Public Sector Collective Agreement (Tarifvertrag für den öffentlichen Dienst–TVöD Bund).

The professional qualification of early career researchers is of great importance for DZNE. Besides special offers for career development and support, it also provides researchers career opportunities in form of junior research groups or internal career paths to obtain scientific independence.