Jobs

ERC-Funded Postdoc Position to Investigate the Cellular Phase of Alzheimer’s Disease Using Spatial Transcriptomics and Proteomics

Employer

VIB

Location

Flanders, Belgium

Principal Investigator

Bart De Strooper

Contact

bart.destrooper@kuleuven.be

Description

The Laboratory for the Research of Neurodegenerative Diseases headed by Prof. Bart De Strooper is a vibrant environment where key issues related to Alzheimer’s disease are tackled. Within the frame of an ERC advanced grant, we are currently looking for a highly skilled and motivated postdoc to join our multidisciplinary project on the cellular response to Alzheimer’s pathology. In this project we will investigate the expression of risk genes for Alzheimer’s disease and how their expression changes in different cell types over the course of Alzheimer’s disease.

Understanding how risk genes are expressed over the disease evolution will help us to identify new drug targets. The candidate will use spatial omics such as spatial transcriptomics, in situ sequencing, and multiplexed proteomics to untangle the cellular response to amyloid plaques and tangles in resilient and Alzheimer’s brains.

Requirements

Required:

  • Ph.D. in biomedicine, genetics, bioengineering or equivalent.
  • Strong background in molecular biology.
  • Interested to work in the field of Alzheimer’s disease.
  • Critical mindset, fast learner, and team player.
  • Ability to collaboratively lead a multidisciplinary project with international and national partners in academia, industry, and the clinics.
  • Project management and effective communication skills.
  • Good mastery of English language.

Appreciated:

  • Experience in image analysis.
  • Strong background and hands-on experience with brain pathology.
  • Familiarity with R or python.
  • Solid scientific and operational knowledge of fit-for-purpose.
  • State-of-the-art omics platforms (transcriptomic, genetics, proteomics), at single-cell resolution and the selection and application of appropriate data analysis methodologies, especially in the context of human translational studies.
  • Knowledge on the genetics of Alzheimer’s disease.