Posted 13 Dec 2019
German Center for Neurodegenerative Diseases (DZNE)
Population Health Sciences is one of the major scientific areas of the DZNE. The Schmandke research team aims to understand the complex and heterogeneous causes of neurodegenerative and other age-related diseases in order to contribute to their effective, individualized prevention and treatment. Specifically, the team investigates the interplay between the genome and the exposome in determining health status. The research is based on the Rhineland Study, a population-based cohort that will include more than 20,000 people aged 30 years and older and is designed to run for decades.
The Rhineland Study emphasizes deep phenotyping. Besides detailed clinical data, the team collects extensive -omics information from all participants, including genomic, epigenomic, transcriptomic, metabolomic, proteomic, as well as microbiomic data. These multi-omics data are of critical importance to most of the ongoing as well as future research projects, which aim to identify and understand the molecular and biochemical pathways that mediate the effects of various risk factors on brain structure and function.
The researcher will play a key role in the development of the multi-omics platform of the Rhineland Study and in research projects involving -omics data. These projects will not be confined to local studies, but will also include close collaborations in various large international consortia. Depending on the researcher's level of expertise, he or she will be offered the opportunity to develop and lead his or her own research projects as it fit within the general research interests of the group:
- Processing and analyzing multi-scale omics data (including genotyping arrays, DNA/RNA sequencing and metabolomics data).
- Analysis of data and preparation of manuscripts for publication in peer-reviewed journals.
- Maintaining contact with internal and external academic and industrial partners.
The position offers interesting and challenging work on the forefront of health research; working on a highly interdisciplinary and international team; a high potential for the development of the researcher's own profile. The researcher will obtain special skills and knowledge for scientific qualification.
The position is initially limited to 31.07.21, with the possibility of extension. The common language at work is English. Employment, payment and social benefits are determined by the Public Sector Collective Agreement (Tarifvertrag für den öffentlichen Dienst–TVöD Bund).
DZNE is looking for a highly talented, motivated, enthusiastic, and ambitious researcher with good social skills. Successful candidates should have a Ph.D. in computational biology, molecular biology, biostatistics, (bio)medical sciences, or a related discipline and extensive experience in bioinformatics and large-scale multi-omics projects, including genomics, epigenomics, transcriptomics, or metabolomics. Demonstrated interest in quantitative research, strong analytical skills, ability for independent and critical thinking, and excellent communication and writing skills in the English language are a prerequisite.