Assistant Project Scientist


University of California, Irvine


Irvine, California

Principal Investigator

Michael Yassa


Please submit a letter of interest, curriculum vitae which should include a record of research experience, and the names of three references by November 19, 2018, to:


The University of California, Irvine’s Institute for Memory Impairments and Neurological Disorders has an opportunity for an assistant project scientist to join the UCI Model Organism Development and Evaluation for Late-onset Alzheimer’s Disease (MODEL-AD) Disease Modeling Project (DMP).

MODEL-AD is a NIA/NIH-funded multiproject, multiinstitutional grant whose goal is to produce the next generation of mouse models for late-onset AD and develop new therapeutic targets. The current position will characterize these new models using magnetic resonance imaging (MRI)-derived metrics. Specifically, the candidate will use MRI to explore structural (diffusion tensor imaging; DTI) and functional (resting state functional MRI; rsfMRI) connectivity as well as assessment of brain wide structures (volumetrics). Under the direction of Michael Yassa, professor and director of the Center for the Neurobiology of Learning and Memory, and Andre Obenaus, professor and director of the UCI Preclinical and Translational Imaging Center (PTIC), the successful applicant will be responsible for acquisition, analysis and interpretation of MRI-derived data in improved mouse models of late-onset Alzheimer’s disease. The project involves use of contemporary methods of MR data acquisition, optimization of new and existing analysis pipelines and integration of these data with the MODEL-AD members. Responsibilities also include supervision of scientific research assistant(s) and student research assistant(s), as needed.

The University of California, Irvine, is an Equal Opportunity/Affirmative Action Employer committed to excellence through diversity. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.


A doctoral degree in neuroscience or related degree is required. Individuals with a minimum of 10 years experience in neuroscience and/or imaging are encouraged to apply. Preference will be given to candidates with demonstrated experience in: in vivo and ex vivo MR acquisition, DTI and rsfMRI methods, animal handling particularly anesthesia methods, MR analysis methods, and some programming skills. Knowledge of brain regions affected by Alzheimer’s disease and its etiology is helpful. Ability to undertake histological and immunocytochemical protocols and the ability to co-register these to MRI will also be a strength. Eligible candidates should also have experience in Linux (Mac) and Windows software, use of spreadsheets and graphing software, database use and management, and strong record-keeping skills. Excellent supervisory skills, the ability to work independently, including setting team and personal goals and meeting deadlines, and strong communication skills are essential.