Antibody

β-APP

Clonality: polyclonal
Host: Rabbit
Methods: ELISA, IF, IH, WB
Source: Zymed/ Invitrogen
Cat# 51-2700
(CT695)
References:
Muresan, 2009
Burton, 2008
Wahrle, 2008
Formulation: affinity purified, PBS, azide
Reactivity:
Reacts in: Pig, Human, Mouse, Rat

Immunogen/Epitope

Immunogen = synthetic peptide of 22 aa from the C-terminus of human β-APP

Specificity

All three forms of full length APP and N-terminal truncated forms of β-APP. Detects C-terminal membrane fragment of β-APP that remains after α -or β-secretase cleavage

Comments / Questions

No Available Comments

Make a comment or submit a question

To make a comment you must login or register.

References

Paper Citations

  1. . The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites. J Neurosci. 2009 Mar 18;29(11):3565-78. PubMed.
  2. . The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression. J Biol Chem. 2008 Aug 22;283(34):22992-3003. PubMed.
  3. . Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. J Clin Invest. 2008 Feb;118(2):671-82. PubMed.

Further Reading