Antibody

β-Amyloid oligomers (NU-1)

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Clonality: monoclonal
Host: Mouse
Source: Mary Lambert
Reactivity:
Reacts in: Human, Mouse

Immunogen/Epitope

The immunogen is Aβ oligomers, specifically amyloid β-derived diffusible ligands (ADDLs), mixed with Freund's adjuvant

Specificity

Strong preferential binding for Aβ oligomers over monomers; neutralizes binding of endogenous and synthetic ADDLs to cultured cells; binds strongly to Alzheimer's disease brain samples but not to control brain samples; reactivity prominent in the hippocampus, entorhinal cortex, and middle frontal gyrus of Alzheimer's disease brain

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Further Reading

Papers

  1. Varvel NH, Bhaskar K, Patil AR, Pimplikar SW, Herrup K, Lamb BT. Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease. J Neurosci. 2008 Oct 22;28(43):10786-93. PubMed.
  2. Jimenez S, Baglietto-Vargas D, Caballero C, Moreno-Gonzalez I, Torres M, Sanchez-Varo R, Ruano D, Vizuete M, Gutierrez A, Vitorica J. Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic. J Neurosci. 2008 Nov 5;28(45):11650-61. PubMed.
  3. Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, Ito K, Shimada H, Lambert MP, Klein WL, Mori H. A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J Neurosci. 2010 Apr 7;30(14):4845-56. PubMed.