Antibody

α-Tubulin (DM1A)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: Sigma Aldrich
Cat# F2168
References:
Frost, 2009
Tatebayashi, 2002
Stamer, 2002
Lee, 2002
Formulation: protein-A purified, gel filtered, PBS, BSA, azide, FITC conj.
Reactivity:
Reacts in: Amphibian (various), Bovine, Goat, Chicken, Sea Urchin, Fungi, Yeast, Kangaroo, Human, Monkey, Gerbil, Hamster, Mouse, Rat, Nicotiana tabacum, Trypanosome

Immunogen/Epitope

immunogen = purified chick brain microtubules (epitope in the C-terminal of α-tubulin)

Specificity

detects the carboxy-terminal part of alpha-tubulin

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References

Paper Citations

  1. Frost B, Jacks RL, Diamond MI. Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem. 2009 May 8;284(19):12845-52. PubMed.
  2. Tatebayashi Y, Miyasaka T, Chui DH, Akagi T, Mishima K, Iwasaki K, Fujiwara M, Tanemura K, Murayama M, Ishiguro K, Planel E, Sato S, Hashikawa T, Takashima A. Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13896-901. PubMed.
  3. Stamer K, Vogel R, Thies E, Mandelkow E, Mandelkow EM. Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J Cell Biol. 2002 Mar 18;156(6):1051-63. PubMed.
  4. Lee SF, Shah S, Li H, Yu C, Han W, Yu G. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch. J Biol Chem. 2002 Nov 22;277(47):45013-9. PubMed.

Further Reading

No Available Further Reading