Antibody

α-Tubulin (DM1A)

Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: IC, IH, IP, RIA, WB
Source: Sigma Aldrich
Cat# T6199
References:
( Decker, 2010
Tackenberg, 2009
Nicholson, 2009
unspecified formulation)
Tanemura, 2006
Formulation: liquid, purified IgG, PBS, BSA, azide<br />Also available as ascites and as FITC conj.
Reactivity:
Reacts in: Bovine, Chicken, Human, Mouse

Immunogen/Epitope

immunogen = purified chick brain tubulin (epitope at aa 426-430)

Specificity

recognizes an epitope located at the C-terminal end of alpha-tubulin

Comments / Questions

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References

Paper Citations

  1. . Amyloid-beta peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3beta in primary cultured hippocampal neurons. J Neurosci. 2010 Jul 7;30(27):9166-71. PubMed.
  2. . Divergent pathways mediate spine alterations and cell death induced by amyloid-beta, wild-type tau, and R406W tau. J Neurosci. 2009 Nov 18;29(46):14439-50. PubMed.
  3. . Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity. J Neurosci. 2009 Apr 8;29(14):4640-51. PubMed.
  4. . Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1). J Biol Chem. 2006 Feb 24;281(8):5037-41. PubMed.

Further Reading

No Available Further Reading