Antibody

Trk A, phos Tyr490

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Clonality: polyclonal
Host: Rabbit
Source: Cell Signaling
Cat# 9141
References:
Chen, 2010
Dorsey, 2006
Formulation: liquid, protein-A affinity purified, HEPES, saline, BSA, glycerol
Reactivity:
Reacts in: Rat
expect human, mouse from homology

Immunogen/Epitope

immunogen = a synthetic phospho-peptide
(KLH-coupled) corresponding to residues surrounding
Tyr490 of human TrkA

Specificity

recognizes endogenous levels of TrkA only when phosphorylated at Tyr490, also detects TrkB or TrkC when phosphorylated at the corresponding residues.

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References

Paper Citations

  1. Chen LY, Rex CS, Sanaiha Y, Lynch G, Gall CM. Learning induces neurotrophin signaling at hippocampal synapses. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7030-5. PubMed.
  2. Dorsey SG, Renn CL, Carim-Todd L, Barrick CA, Bambrick L, Krueger BK, Ward CW, Tessarollo L. In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model. Neuron. 2006 Jul 6;51(1):21-8. PubMed.

Further Reading

No Available Further Reading