Antibody

Tau (TG-3)

Tools

Back to the Top

Clonality: monoclonal
Host: Mouse
Isotype: IgM
Source: Formerly available through Dr. Peter Davies. For updated information, contact antibodies@alzforum.org.
Formulation: IC, IF, IH, IP, WB
Reactivity:
Reacts in: Human

Immunogen/Epitope

Tau phosphorylated at threonine-231; also conformation-sensitive.

Specificity

Tau phosphorylated at threonine-231; also conformation-sensitive. Not reactive to normal tau. The TG3 epitope is expressed in mitotic cells but not in quiescent cells, suggesting that mitotic phosphoepitopes may lead to conformational changes.

Comments / Questions

No Available Comments

Make a comment or submit a question

To make a comment you must login or register.

References

No Available References

Further Reading

Papers

  1. . Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science. 2001 Aug 24;293(5534):1491-5. PubMed.
  2. . Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science. 2001 Aug 24;293(5534):1487-91. PubMed.
  3. . Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. J Neurosci. 2008 Nov 26;28(48):12798-807. PubMed.
  4. . Regulation of tau pathology by the microglial fractalkine receptor. Neuron. 2010 Oct 6;68(1):19-31. PubMed.