Antibody

Tau (TAU-5)

Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: ELISA, IH, IP, WB
Source: Biosource Invitrogen
Cat# AHB0042
References:
Bhaskar K, 2010
Ittner, 2010
Clavaguera, 2009
Nicholson, 2009
Chu, 2009
Lesne, 2005
Formulation: ascites, affinity purified BSA, azide, unconj.
Reactivity:
Reacts in: Cow, Sheep, Human, Mouse, Rat
others not tested

Immunogen/Epitope

immunogen = purified bovine microtuble associated proteins; epitope in middle region of tau

Specificity

tau proteins ranging from 45-68 kDa, not other MAPs or tubulin; tangles marker; reacts with non-phosphor. and phosphor. tau

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References

Paper Citations

  1. . Regulation of tau pathology by the microglial fractalkine receptor. Neuron. 2010 Oct 6;68(1):19-31. PubMed.
  2. . Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell. 2010 Aug 6;142(3):387-97. Epub 2010 Jul 22 PubMed.
  3. . Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol. 2009 Jul;11(7):909-13. PubMed.
  4. . Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity. J Neurosci. 2009 Apr 8;29(14):4640-51. PubMed.
  5. . A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2097-103. PubMed.
  6. . A specific amyloid-beta protein assembly in the brain impairs memory. Nature. 2006 Mar 16;440(7082):352-7. PubMed.

Further Reading

No Available Further Reading