Antibody

Tau (TAU-5)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: BD Pharmingen
Cat# 556319
References:
Alonso, 2010
Tackenberg, 2009
Frost, 2009
Shahani, 2006
Formulation: aqueous buffered liquid, supernate, affinity purified, azide
Reactivity:
Reacts in: Rat

Immunogen/Epitope

immunogen = phosphorylation -independent region in the middle of Tau

Specificity

recognizes both phos. and non phos. forms of Tau

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References

Paper Citations

  1. Alonso AD, Di Clerico J, Li B, Corbo CP, Alaniz ME, Grundke-Iqbal I, Iqbal K. Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration. J Biol Chem. 2010 Oct 1;285(40):30851-60. PubMed.
  2. Tackenberg C, Brandt R. Divergent pathways mediate spine alterations and cell death induced by amyloid-beta, wild-type tau, and R406W tau. J Neurosci. 2009 Nov 18;29(46):14439-50. PubMed.
  3. Frost B, Jacks RL, Diamond MI. Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem. 2009 May 8;284(19):12845-52. PubMed.
  4. Shahani N, Subramaniam S, Wolf T, Tackenberg C, Brandt R. Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices. J Neurosci. 2006 May 31;26(22):6103-14. PubMed.

Further Reading

No Available Further Reading