Antibody

Tau, RD3 (8E6/C11)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG
Source: Upstate and Chemicon are Millipore
Cat# 05-803
References:
Luo, 2007
deSilva, 2006
Formulation: supernatant, azide
Reactivity:
Reacts in: Human
expect mouse, bovine

Immunogen/Epitope

immunogen = synthetic peptide corresp. to aa 209-224 (K H Q P G G G K V Q I V Y K P V) of human Tau (3-repeat isoform RD3). Region is flanking junction coded by adjacent exons 9 & 11 in the absence of exon 10, conj. to bovine thyroglobulin

Specificity

tau (3-repeat isoform RD3)

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References

Paper Citations

  1. Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, Moulick K, Aguirre J, Wu N, Greengard P, Chiosis G. Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9511-6. PubMed.
  2. de Silva R, Lashley T, Strand C, Shiarli AM, Shi J, Tian J, Bailey KL, Davies P, Bigio EH, Arima K, Iseki E, Murayama S, Kretzschmar H, Neumann M, Lippa C, Halliday G, Mackenzie J, Ravid R, Dickson D, Wszolek Z, Iwatsubo T, Pickering-Brown SM, Holton J, Lees A, Revesz T, Mann DM. An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies. Acta Neuropathol. 2006 Apr;111(4):329-40. PubMed.

Further Reading

No Available Further Reading