Antibody

Tau pS214

Clonality: polyclonal
Host: Rabbit
Methods: WB
Source: Biosource Invitrogen
Cat# 44-742G
References:
Zempel H, 2010
Alonso, 2010
Shahani, 2006
Formulation: affinity purified Ig, Dulbecco's PBS, BSA, glycerol, unconjugated
Reactivity:
Reacts in: Human
expect mouse, rat, rhesus monkey, baboon, cow, goat

Immunogen/Epitope

phospho peptide derived from the region of human Tau that contains serine 214

Specificity

detects tau phosphorylated at serine 204; no cross with non phosphorylated tau

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References

Paper Citations

  1. . Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. J Neurosci. 2010 Sep 8;30(36):11938-50. PubMed.
  2. . Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration. J Biol Chem. 2010 Oct 1;285(40):30851-60. PubMed.
  3. . Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices. J Neurosci. 2006 May 31;26(22):6103-14. PubMed.

Further Reading

No Available Further Reading