Antibody

Tau pS214

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Clonality: polyclonal
Host: Rabbit
Source: Biosource Invitrogen
Cat# 44-742G
References:
Zempel H, 2010
Alonso, 2010
Shahani, 2006
Formulation: affinity purified Ig, Dulbecco's PBS, BSA, glycerol, unconjugated
Reactivity:
Reacts in: Human
expect mouse, rat, rhesus monkey, baboon, cow, goat

Immunogen/Epitope

phospho peptide derived from the region of human Tau that contains serine 214

Specificity

detects tau phosphorylated at serine 204; no cross with non phosphorylated tau

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References

Paper Citations

  1. Zempel H, Thies E, Mandelkow E, Mandelkow EM. Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. J Neurosci. 2010 Sep 8;30(36):11938-50. PubMed.
  2. Alonso AD, Di Clerico J, Li B, Corbo CP, Alaniz ME, Grundke-Iqbal I, Iqbal K. Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration. J Biol Chem. 2010 Oct 1;285(40):30851-60. PubMed.
  3. Shahani N, Subramaniam S, Wolf T, Tackenberg C, Brandt R. Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices. J Neurosci. 2006 May 31;26(22):6103-14. PubMed.

Further Reading

No Available Further Reading