Antibody

Tau phos Ser202 (CP13)

Clonality: monoclonal
Host: Mouse
Isotype: IgG2b
Source: Formerly available through Dr. Peter Davies. For updated information, contact antibodies@alzforum.org.
Reactivity:
Reacts in: Human

Immunogen/Epitope

epitope around phospho-serine 202

Specificity

Detects tau phosphorylated at serine-202.

Comments / Questions

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References

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Further Reading

Papers

  1. . The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease. Neurobiol Dis. 2006 Aug;23(2):398-408. PubMed.
  2. . Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9511-6. PubMed.
  3. . Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science. 2007 May 4;316(5825):750-4. PubMed.
  4. . High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model. Neurobiol Aging. 2010 Sep;31(9):1516-31. Epub 2008 Oct 15 PubMed.
  5. . Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. J Neurosci. 2008 Nov 26;28(48):12798-807. PubMed.
  6. . Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration. Am J Pathol. 2009 Oct;175(4):1598-609. PubMed.
  7. . Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. J Neurosci. 2009 Aug 26;29(34):10741-9. PubMed.
  8. . Regulation of tau pathology by the microglial fractalkine receptor. Neuron. 2010 Oct 6;68(1):19-31. PubMed.
  9. . AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies. Acta Neuropathol. 2011 Mar;121(3):337-49. PubMed.