Tau, C-term 4 repeats

Clonality: polyclonal
Host: Rabbit
Isotype: Ig
Methods: IC, IH, IP, WB
Source: DAKO
cat# A0024
see From the Lab. antibody K9JA, (EM Mandelkow)
Zempel H, 2010
van Eersel, 2010
Ittner, 2010
Wang, 2009
Paquet, 2009
Planel, 2008
Chacón, 2008
Adlard, 2008
Yuan, 2008
Khurana, 2006
Guo, 2006
Formulation: serum, purified Ig fraction, azide
Reacts in: Human, Mouse, Rat


immunogen = C-terminal part of human tau protein expressed in E. coli; aa. 243-441, contains the four repeated sequences involved in microtubule binding (MTB)


reacts with tau protein and with tau from Alzheimer paired helical filaments; also MAP2; well-suited for gel immunoprecipitation techniques


not I

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Antibody Citations

  1. Tau, 4-repeat section

Paper Citations

  1. . Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. J Neurosci. 2010 Sep 8;30(36):11938-50. PubMed.
  2. . Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13888-93. PubMed.
  3. . Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell. 2010 Aug 6;142(3):387-97. Epub 2010 Jul 22 PubMed.
  4. . Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. Hum Mol Genet. 2009 Nov 1;18(21):4153-70. PubMed.
  5. . A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. J Clin Invest. 2009 May;119(5):1382-95. PubMed.
  6. . Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. J Neurosci. 2008 Nov 26;28(48):12798-807. PubMed.
  7. . Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Abeta oligomers. J Cell Physiol. 2008 Oct;217(1):215-27. PubMed.
  8. . Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron. 2008 Jul 10;59(1):43-55. PubMed.
  9. . Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. J Neurosci. 2008 Feb 13;28(7):1682-7. PubMed.
  10. . TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. Curr Biol. 2006 Feb 7;16(3):230-41. PubMed.
  11. . Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1953-8. PubMed.

Further Reading

No Available Further Reading