Antibody

Tau (AT8)

Clonality: monoclonal
Host: Mouse
Isotype: IgG1κ
Methods: ELISA, IH, WB
Source: References:
Clinton, 2010
Gijselinck, 2010
Leinonen, 2008
Brouwers, 2007
Rockenstein, 2007
Khurana, 2006
Tanemura, 2006

Formulation: liquid, PBS, sterile filtered, affinity purified
Reactivity:
Reacts in: Human

Immunogen/Epitope

partially purified human tau, aa. around phosphorylated Serine 202

Specificity

Recognizes phosphorylated paired helical filament tau. Recognises tau protein phosphorylated at both serine 202 and threonine 205. No cross-reactivity with unphoshorylated tau.

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References

Paper Citations

  1. . Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline. J Neurosci. 2010 May 26;30(21):7281-9. PubMed.
  2. . Identification of 2 Loci at chromosomes 9 and 14 in a multiplex family with frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Arch Neurol. 2010 May;67(5):606-16. PubMed.
  3. . Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B. Arch Neurol. 2008 Oct;65(10):1304-9. PubMed.
  4. . Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family. Arch Neurol. 2007 Oct;64(10):1436-46. PubMed.
  5. . Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation. J Neurosci. 2007 Feb 21;27(8):1981-91. PubMed.
  6. . TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. Curr Biol. 2006 Feb 7;16(3):230-41. PubMed.
  7. . Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1). J Biol Chem. 2006 Feb 24;281(8):5037-41. PubMed.

Further Reading

No Available Further Reading