Antibody

Tau (AT180)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1,κ
Source: Innogenetics
cat# BR-027
references:
Tatebayashi, 2002
Lewis, 2001
distributed by Autogen Bioclear as 90218
Formulation: liquid, PBS, sterile filtered, no preservative, affinity purified, biotin
Reactivity:
Reacts in: Human

Immunogen/Epitope

immunogen = human tau40, aa. around phospho.Thr 231

Specificity

PHF tau and tau in tangles, phospho at Thr 231; weak cross with normal tau; no cross with recomb. non-phos. human tau

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References

Paper Citations

  1. Tatebayashi Y, Miyasaka T, Chui DH, Akagi T, Mishima K, Iwasaki K, Fujiwara M, Tanemura K, Murayama M, Ishiguro K, Planel E, Sato S, Hashikawa T, Takashima A. Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13896-901. PubMed.
  2. Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, Yen SH, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science. 2001 Aug 24;293(5534):1487-91. PubMed.

Further Reading

No Available Further Reading