Antibody

TARDPB /TDP-43

Clonality: polyclonal
Host: Rabbit
Isotype: IgG
Methods: ELISA, IH, WB
Source: Proteintech Group, Inc.
10782-2-AP
References:
(Liu-Yesucevitz, 2010, unspecified immunogen)
Wegorzewska, 2009
Rademakers, 2008
Steinacker, 2008
Zhang, 2008
Winton, 2008
Formulation: liquid, affinity purified, PBS, azide, glycerol
Reactivity:
Reacts in: Human, Mouse, Rat

Immunogen/Epitope

immunogen = recombinant Protein (raised to aa 1-260)

Specificity

detects 43kDa TARDBP

Comments / Questions

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References

Paper Citations

  1. . Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue. PLoS One. 2010;5(10):e13250. PubMed.
  2. . TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18809-14. Epub 2009 Oct 15 PubMed.
  3. . Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. Hum Mol Genet. 2008 Dec 1;17(23):3631-42. PubMed.
  4. . TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Arch Neurol. 2008 Nov;65(11):1481-7. PubMed.
  5. . Epitope mapping of 2E2-D3, a monoclonal antibody directed against human TDP-43. Neurosci Lett. 2008 Mar 28;434(2):170-4. PubMed.
  6. . Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation. J Biol Chem. 2008 May 9;283(19):13302-9. PubMed.

Further Reading

No Available Further Reading