Antibody

α-Synuclein

Clonality: monoclonal
Host: Mouse
Methods: IH, WB
Source: α-Synuclein LB509
(Takeshi Iwatsubo, Department of Neuropathology & Neuroscience, Grad. School of Pharmaceutical Sciences, University of Tokyo)
Also see Abcam ab27766,
SantaCruz sc-58480, and others.
References:
Tokuda, 2010
Tsika, 2010
Xu, 2002
Reactivity:
Reacts in: Human
Paper: <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1858234/pdf/amjpathol00016-0033.pdf" target="_new">Baba M., et al.</a>, Amer. J. Pathol. 152:879-884,1998

Immunogen/Epitope

(epitope at the C terminus of the protein, residues 115-122)

Specificity

detects α-Synuclein, C-terminal

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References

Paper Citations

  1. . Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease. Neurology. 2010 Nov 16;75(20):1766-72. PubMed.
  2. . Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration. J Neurosci. 2010 Mar 3;30(9):3409-18. PubMed.
  3. . Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat Med. 2002 Jun;8(6):600-6. PubMed.

External Citations

  1. Takeshi Iwatsubo
  2. Baba M., et al.

Further Reading