Antibody

α-Synuclein

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Clonality: polyclonal
Host: Rabbit
Source: Chemicon and Upstate are Millipore
cat# AB5038
References:
Clinton, 2010
Paleologou, 2010, both, unspecified formulation
Formulation: lyophilized, serum, no preservative
Reactivity:
Reacts in: Human, Rat
others not tested

Immunogen/Epitope

immunogen = peptide seq. N-G I L E D M P V D P D N E A Y E M P S E E C-C, corresp. to human α-synuclein a.a. 111-131 coupled to KLH

Specificity

detects α-synuclein (14-19kDa); the immunizing peptide was chosen to reduce cross-reactivity of AB5038 with β-synuclein to a minimum

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References

Paper Citations

  1. Clinton LK, Blurton-Jones M, Myczek K, Trojanowski JQ, Laferla FM. Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline. J Neurosci. 2010 May 26;30(21):7281-9. PubMed.
  2. Paleologou KE, Oueslati A, Shakked G, Rospigliosi CC, Kim HY, Lamberto GR, Fernandez CO, Schmid A, Chegini F, Gai WP, Chiappe D, Moniatte M, Schneider BL, Aebischer P, Eliezer D, Zweckstetter M, Masliah E, Lashuel HA. Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. J Neurosci. 2010 Mar 3;30(9):3184-98. PubMed.

Further Reading