Antibody

α-synuclein (42)

Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: IF, WB
Source: BD Transduction
Cat# 610786, 50 μg
610787 150 μg
References:
Burré J, 2010
Machiya, 2010
Emmanouilidou, 2010
Paleologou, 2010
Scherzer, 2008
Tetzlaff, 2008
Zhang, 2008
Yamaguchi, 2007
Kallhoff, 2007
Xu, 2002
Formulation: liquid, BSA, glycerol, azide, positive control
Reactivity:
Reacts in: Human, Mouse, Rat

Immunogen/Epitope

immunogen = aa. 15-123 of rat synuclein-1

Specificity

Synuclein-1,mol. wt. = 19kDa

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References

Paper Citations

  1. . Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science. 2010 Sep 24;329(5999):1663-7. PubMed.
  2. . Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner. J Biol Chem. 2010 Dec 24;285(52):40732-44. PubMed.
  3. . Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival. J Neurosci. 2010 May 19;30(20):6838-51. PubMed.
  4. . Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. J Neurosci. 2010 Mar 3;30(9):3184-98. PubMed.
  5. . GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10907-12. PubMed.
  6. . CHIP targets toxic alpha-Synuclein oligomers for degradation. J Biol Chem. 2008 Jun 27;283(26):17962-8. PubMed.
  7. . Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice. Mol Neurodegener. 2007;2:10. PubMed.
  8. . Lack of alpha-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease. Mol Neurodegener. 2007;2:6. PubMed.
  9. . Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat Med. 2002 Jun;8(6):600-6. PubMed.

Further Reading