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Antibodies

853 Results

Name Source Clonality &
Isotype
Host &
Formulation
Method Reactivity Immunogen/
Epitope
Specificity Availability
γ-secretase/ Presenilins From labs (9)
B24.2(Bart De Strooper,K.U.Leuven, Belgium)PaperReference: Zhao, 2010 polyclonal
Rabbit
(liquid, supernatant)
WB Mouse immunogen = the peptide KLDPSSQGAL QLPYDPEMEE (amino acids 306–325), coupled to KLH detects C-terminal fragments of PS-2 -
anti-PS1-NT1(Paul Mathews, New York University, School of Medicine,Center for Dementia Research)produced by CovanceReference: Gu, 2002 monoclonal
IgG1
Mouse
(purified)
IP, WB Primate (various), Human directed against residues 41-49 (RRSLGHPEP) of PS-1 recognizes full length PS-1 and the ~28 kDa amino-terminal fragment produced by in vivo proteolysis in L cells overexpressing PS1, but not proteins in mouse L cells overexpressing human PS2. NT1 recognized multiple bands migrating between 28 kDa and 35 kDa from human prefrontal cortex -
anti-PS1-C(Hui Zheng, Huffington Center on Aging, Baylor College of Medicine)used in paper by Xia, 2002 polyclonal
Rabbit
WB - aa 454-467 of PS1 with glutamate residue added to N terminus to enhance solubility   -
B17(Bart De Strooper,K.U.Leuven, Belgium)Reference: Sato, 2007 polyclonal
Rabbit
IP Human, Mouse immunogen = peptide p46 (EGDPEAQR RVSKNSKC), situated in the hydrophilic loop domain of PS1Paper PS1, hydrophilic loop-specific -
PS1-BI.3D7(Christian Haass,Adolf Butenandt Institute, University of Munich)used in paper by Steiner, 2002 monoclonal

- - fusion protein, C-terminal (aa 263-407) N terminus of PS-2 -
PS2 (GL2)(Takeshi Iwatsubo, Department of Neuropathology & Neuroscience, Grad. School of Pharmaceutical Sciences, University of Tokyo)References:Zhao, 2010Yu, 2001 polyclonal
Rabbit
IH, WB Human immunogen = GST fused to amino acids 301–361 of human PS2 detects C-terminus of PS-2 -
anti-αPS1 Loop(Gopal Thinakaran, Department of Neurobiology, University of Chicago)References:Veeraraghavalu, 2010Yu, 2001Luo, 2003 polyclonal
Rabbit
IH Human, Mouse immunogen = aa 320-375 of human PS1 reacts with epitopes in the hydrophilic loop domain (amino acids 263–407) of human and mouse PS1; no cross reactivity of PS1Loop antiserum with the human PS2 fusion protein -
PS1NT(Gopal Thinakaran, Department of Neurobiology, University of Chicago)References: Veeraraghavalu, 2010O'Connor, 2008Ikeuchi, 2003 polyclonal
Rabbit
WB - (epitope contains residues 1–65 of the N-terminus of PS1) full-length PS1 and NH2-terminal fragment of PS1 -
4627Dr. Dennis Selkoe,Harvard Univ. Medical School, Boston, MAReference: Sato, 2007 polyclonal
Rabbit
IP Human, Hamster, Mouse immunogen = synthetic peptide corresp. to the C-terminal 10 amino acids of PS1 (aa 457-467) Paper extreme C-terminal PS1, and PS1 CTF -
γ-secretase/ Presenilins From manufacturers (44)
Chemicon and Upstate are Millipore monoclonal
IgG1
Mouse
(liquid, ascites, no preservative)
IC, IH, IP, WB Primate (various), Mouse, Rat immunogen = Presenilin-1, loop fusion protein, C-terminal (amino acids 263-378), human Presenilin-1, loop. -
Abcam polyclonal
IgG
Rabbit
(liquid, affinity purified, PBS, azide)
IC, IF, WB Human, Mouse, Rat immunogen = synthetic peptide (Human) of 13 amino acids from near the C-terminus of PEN2 detects Carboxy terminal end of PEN2 protein -
Zymed/ Invitrogen polyclonal
Rabbit
(liquid, PBS, azide, affinity purified)
IP, WB Human, Mouse immunogen = synthetic peptide derived from the C-terminal region of human Aph-1a Aph-1a (~23kDa) long isoform only -
A B R - Thermo Scientific polyclonal
IgG
Rabbit
(epitope affinity purified IgG, PBS, BSA, azide)
WB Human, Mouse immunogen = synthetic peptide corr. to aa 688-708 of human nicastrin; one aa substitution between human and mouse sequence Nicastrin in tissues and cells; ~110 kDa in WB -
A B R - Thermo Scientific polyclonal
IgG
Rabbit
(liquid, PBS, azide)
WB Human, Mouse, Rat immunogen = a 18 amino acid peptide sequence near the internal region of human nicastrin detects Nicastrin -
A B R - Thermo Scientific polyclonal
IgG
Rabbit
(liquid, PBS, azide)
WB Human, Mouse, Rat immunogen = a 17 amino acid peptide sequence near the carboxy terminus of human nicastrin detects Nicastrin -
A B R - Thermo Scientific polyclonal
Rabbit
(liquid, serum, azide)
IP, WB Human immunogen = synthetic peptide corresp. to aa residues F Q I Y R P R W G A L G D Y L S F T I P L G T P of human Pen2 Pen-2 -
A B R - Thermo Scientific polyclonal
Rabbit
(liquid, PBS, azide)
WB Human, Mouse, Rat immunogen = a 13 amino acid peptide sequence near the amino terminus of human PEN2. detects Pen-2, N-terminal -
A B R - Thermo Scientific polyclonal
IgG
Rabbit
(IgG affinity purified, lyophilized)
WB Human, Hamster, Mouse immunogen = a synthetic peptide, conjugated to KLH, corresponding to the 11 most N-terminal residues of human Pen-2 detects Pen-2 -
A B R - Thermo Scientific polyclonal
Rabbit
(liquid, affinity purified, PBS, BSA, azide, glycerol)
IF, IP, WB Human, Mouse immunogen = Synthetic peptide, KLH conjugated, corresponding to residues C(245)RRQEDSRVM VYSALRIPPED(265) of human APH-1aL/C-terminal recognizes APH-1 -
Sigma Aldrich polyclonal
Rabbit
(buffered aqueous solution , IgG fract, PBS, azide)
WB Human immunogen = synthetic peptide corr to C-terminus, aa 693-709 of human nicastrin, conj. to KLH detects Nicastrin -
Santa Cruz monoclonal
IgG2b
Mouse
(liquid, PBS, azide, protein stabilizer)
IF, IP, WB Human immunogen = amino acids 1-80 of Presenilin 1 of human origin for detection of Presenilin 1 NTF subunit of human origin; no cross with Presenilin 2 or Presenilin 1 CTF subunit -
Calbiochem EMD Biosciences polyclonal
IgG
Rabbit
(affinity purified IgG, PBS, azide, gelatin)
IH, WB Human, Mouse, Rat synthetic peptide (EEDSYDSFGEPS) corr. to aa 324-335 from the C-terminus of human PS2 detects ~20 kDa proteolytic fragment of presenilin-2 -
Calbiochem EMD Biosciences polyclonal
IgG
Rabbit
(liquid, purified, PBS, azide, gelatin or glycerol)
IB, IF Mouse, Rat immunogen = aa 31-46 of N-terminus of mouse PS-1 recognizes the ~98 kDa presenilin-1 dimer. -
Calbiochem EMD Biosciences polyclonal
IgG
Rabbit
(liquid, purified, PBS, azide, gelatin)
IF, WB Mouse, Rat immunogen = synthetic peptide corrsp. to aa 303-316 of the intracellular loop region of mouse PS-1 ~98k Presenilin-1 dimer -
Calbiochem EMD Biosciences polyclonal
IgG
Goat
(liquid, undiluted serum, azide)
ELISA, IH Human immunogen = synthetic peptide corresp. to aa 14-33 of human presenilin-1 presenilin-1 protein -
Calbiochem EMD Biosciences polyclonal
IgG
Rabbit
(liquid, undiluted serum, no preservative)
IB, IF, IP Human, Monkey, Mouse, Rat immunogen = recomb. protein containing the loop domain (aa 263-407) of human presenilin 1 fusedto GST Recognizes full-lengthpresenilin 1 and its C-terminal fragments -
A D I polyclonal
IgG
Rabbit
(affinity purified with PBS, BSA and merthiolate)
ELISA, IF, IH, IP, WB Human, Mouse, Rat, Xenopus immunogen = a 15 mer peptide (PS11-P) locating to the large hydrophilic loop of human or mouse Presenilin-1 Presenilin-1 -
A D I polyclonal
Rabbit
(unpurified antiserum)
ELISA, IF, IH, IP, WB Human, Mouse, Rat, Xenopus immunogen = a 15 mer peptide (PS11-P) locating to the large hydrophilic loop of human or mouse Presenilin-1 Presenilin-1 -
A D I polyclonal
Goat
(unpurified antiserum)
ELISA, IF, IH, IP, WB Human immunogen = a 20-aa peptide from human Presenilin-1, at the N-terminus, extracellular region Presenilin-1; no cross with PS2 or other known proteins -
A D I polyclonal
IgG
Rabbit
(affinity purified with PBS, BSA and merthiolate)
ELISA, IF, IH, IP, WB Human, Mouse, Rat immunogen = a 18 mer peptide (PS21-P) locating near the amino terminus of Presenilin-2 Presenilin-2 -
A D I polyclonal
Rabbit
(unpurified antiserum)
ELISA, IF, IH, IP, WB Human, Mouse, Rat immunogen = a 18 mer peptide (PS21-P) locating near the amino terminus of Presenilin-2 Presenilin-2 -
BioVision polyclonal
IgG
Rabbit
(liquid, affinity purified, PBS, glycerol, BSA, azide)
WB Human, Mouse, Rat immunogen = synthetic peptide surrounding amino acid 296 of human Presenilin 1 Presenilin-1 -
BioVision polyclonal
Rabbit
(liquid, PBS, glycerol, BSA, thimerosal, affinity purified)
IH, IP, WB Human, Mouse, Rat immunogen = synthetic peptide surrounding amino acid 333 of human presenilin 2 Presenilin-2 -
Vinci Biochem polyclonal
IgG
Rabbit
(epitope affinity purified IgG, PBS, BSA, azide)
WB Human, Mouse immunogen = synthetic peptide corr. to aa 688-708 of human nicastrin; one aa substitution between human and mouse sequence Nicastrin in tissues and cells; ~110 kDa in WB -
VWR International, Inc. monoclonal
IgG1
Mouse
(liquid Ig, purified, PBS, azide)
IC, IH, IP, WB Primate (various), Human, Mouse, Rat aa 263-378 of  Presenilin-1, loop fusion protein Presenilin-1, loop. -
VWR International, Inc. polyclonal
IgG
Rabbit
(affinity purified IgG, PBS, azide, gelatin)
IH, WB Human, Mouse, Rat synthetic peptide corr. to aa 324-335 from the C-terminus of human PS2 ~20 kDa proteolytic fragment of presenilin-2 -
VWR International, Inc. monoclonal
IgG2a
Rat
(liquid, supernatant, no preservative)
ELISA, IH, IP, WB Human N-terminal of human PS-1 aa 21-80 fused to GST neuritic component of senile plaques as well as in neurofibrillary tangles -
VWR International, Inc. polyclonal
Rabbit
(serum, liquid, PBS, azide)
IC, IP, WB Human, Monkey, Hamster, Mouse aa 275-367 of human PS1 fused to C-terminus of maltose binding protein Presenilin 1, loop -
BD Transduction monoclonal
IgG2a
Mouse
(liquid, PBS, BSA, glycerol, azide)
WB Dog, Chicken, Human, Mouse, Rat immunogen = peptide corresp. to aa 168-289 from human nicastrin nicastrin (~110 kDa) -
Calbiochem EMD Biosciences polyclonal
IgG
Rabbit
(liquid, undiluted serum, no preservative)
IF, IP, WB Human, Monkey, Mouse, Rat immunogen = recomb. protein containing aa 1-65 of human presenilin 1 fused to GST Recognizes the presenilin 1 (1-65) holoprotein and its N-terminal fragments -
None polyclonal
Rabbit
(serum, concentrated, no preservative)
IP, WB Human immunogen = peptide (T E L P A P L S Y F N R K C) conj. to KLH presenilin 1 Discontinued
None polyclonal
IgG
Rabbit
(liquid, purified, PBS, no carrier, no preservative)
IP, WB Human immunogen = aa 698-709 of nicastrin nicastrin protein Discontinued
None monoclonal
IgG1
Mouse
(liquid, supernatant)
IF, WB Human immunogen = GST-fusion containing the complete N-terminal fragment of human PS2 (residues 1-87) presenilin 2 Discontinued
None polyclonal
Rabbit
(liquid, affinity purified)
IH, WB Human immunogen = human Aph-1aL/S Loop region 92-115 with seq C K L L K K A D E G L A S L S E D G R S P I S I R Aph-1aL/S loop Discontinued
None polyclonal
Rabbit
(liquid, affinity purified)
IH, WB Human immunogen = human Aph-1b/C-terminal region sequence C Q D K N F L L Y N Q R S R Q D K N F L L Y N Q R S R of human Aph-1b. Aph-1b; some reactivity with Aph-1aL/S Discontinued
None polyclonal
Rabbit
(liquid, affinity purified)
IF, IP, WB Human, Mouse immunogen = C-terminal fragment of nicastrin corresp. to a peptide containing residues 691-709 [C]-N A K A D V L F I A P R E P G A V S Y, conj. to KLH nicastrin Discontinued
None polyclonal
Rabbit
(liquid, affinity purified)
IF, IP, WB Human, Mouse immunogen = N-terminal fragment of nicastrin corresp. to a peptide containing residues 103-124 (C F T R D L M E K L K G R T S R I A G L A V S L), coupled to KLH nicastrin Discontinued
None polyclonal
Rabbit
(liquid, serum)
IP, WB Human immunogen = N-terminal residues of Pen-2 and recognizes the residues E R V S N E E K L N L of Pen-2 Pen2 (12kDa) Discontinued
None polyclonal
Rabbit
(liquid, serum)
IP, WB Human immunogen = C-terminal residues of Pen-2 and recognizes the residues F Q I Y R P R W G A L G D Y L S F T I P L G T P of Pen-2 Pen2 Discontinued
None polyclonal
Rabbit
(affinity purified)
IF, IP, WB Human immunogen = cytoplasmic loop (or C-terminal fragment of PS1) corresp. to a peptide containing residues 368-390[C I L A G E D P E E R G V K L G L G D F I F Y S] Presenilin 1 Discontinued
None polyclonal
Rabbit
(affinity purified)
IF, IP, WB Human immunogen = peptide 1-25 of the human PS1 C M T E L P A P L S Y F Q N A Q M S E D N H L S, coupled to KLH presenilin 1 Discontinued
None polyclonal
Rabbit
(liquid, BSA, glycerol, azide, affinity purified)
IH, WB Human immunogen = human Aph-1b/loop region and recognizes the sequence C K L L K K A S E G L K S I N P G E T A P S M R Aph-1b/loop region Discontinued
BioLegend polyclonal
Rabbit
(liquid, affinity purified)
IH, WB Human immunogen = human Aph-1aL/ C-terminal region sequence C R R Q E D S R V M V Y S A L R I P P E D Aph-1aL Available from BioLegend