The Antibodies database was archived in December 2022 and is no longer being updated. The Antibodies database is being supplanted by the AlzAntibodies database, which aims to provide detailed descriptions of selected antibodies.

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Antibodies

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	Name	Source	Clonality & Isotype	Host & Formulation	Method	Reactivity	Immunogen/ Epitope	Specificity	Availability
γ-secretase/ Presenilins From labs (9)
	PS-2 CTF	B24.2(Bart De Strooper,K.U.Leuven, Belgium)PaperReference: Zhao, 2010	polyclonal	Rabbit (liquid, supernatant)	-	Mouse	immunogen = the peptide KLDPSSQGAL QLPYDPEMEE (amino acids 306–325), coupled to KLH	detects C-terminal fragments of PS-2	-
	PS-1 (NT1)	anti-PS1-NT1(Paul Mathews, New York University, School of Medicine,Center for Dementia Research)produced by CovanceReference: Gu, 2002	monoclonal IgG1	Mouse (purified)	-	Primate (various), Human	directed against residues 41-49 (RRSLGHPEP) of PS-1	recognizes full length PS-1 and the ~28 kDa amino-terminal fragment produced by in vivo proteolysis in L cells overexpressing PS1, but not proteins in mouse L cells overexpressing human PS2. NT1 recognized multiple bands migrating between 28 kDa and 35 kDa from human prefrontal cortex	-
	PS-1	anti-PS1-C(Hui Zheng, Huffington Center on Aging, Baylor College of Medicine)used in paper by Xia, 2002	polyclonal	Rabbit	-	-	aa 454-467 of PS1 with glutamate residue added to N terminus to enhance solubility		-
	PS-1	B17(Bart De Strooper,K.U.Leuven, Belgium)Reference: Sato, 2007	polyclonal	Rabbit	-	Human, Mouse	immunogen = peptide p46 (EGDPEAQR RVSKNSKC), situated in the hydrophilic loop domain of PS1Paper	PS1, hydrophilic loop-specific	-
	PS-1	PS1-BI.3D7(Christian Haass,Adolf Butenandt Institute, University of Munich)used in paper by Steiner, 2002	monoclonal		-	-	fusion protein, C-terminal (aa 263-407)	N terminus of PS-2	-
	PS-2	PS2 (GL2)(Takeshi Iwatsubo, Department of Neuropathology & Neuroscience, Grad. School of Pharmaceutical Sciences, University of Tokyo)References:Zhao, 2010Yu, 2001	polyclonal	Rabbit	-	Human	immunogen = GST fused to amino acids 301–361 of human PS2	detects C-terminus of PS-2	-
	PS-1 loop	anti-αPS1 Loop(Gopal Thinakaran, Department of Neurobiology, University of Chicago)References:Veeraraghavalu, 2010Yu, 2001Luo, 2003	polyclonal	Rabbit	-	Human, Mouse	immunogen = aa 320-375 of human PS1	reacts with epitopes in the hydrophilic loop domain (amino acids 263–407) of human and mouse PS1; no cross reactivity of PS1Loop antiserum with the human PS2 fusion protein	-
	PS-1 NT	PS1NT(Gopal Thinakaran, Department of Neurobiology, University of Chicago)References: Veeraraghavalu, 2010O'Connor, 2008Ikeuchi, 2003	polyclonal	Rabbit	-	-	(epitope contains residues 1–65 of the N-terminus of PS1)	full-length PS1 and NH2-terminal fragment of PS1	-
	PS1, C-terminal	4627Dr. Dennis Selkoe,Harvard Univ. Medical School, Boston, MAReference: Sato, 2007	polyclonal	Rabbit	-	Human, Hamster, Mouse	immunogen = synthetic peptide corresp. to the C-terminal 10 amino acids of PS1 (aa 457-467) Paper	extreme C-terminal PS1, and PS1 CTF	-
γ-secretase/ Presenilins From manufacturers (44)
	Presenilin-1	Sigma Aldrich	polyclonal IgG	Rabbit (liquid, PBS, azide)	-	Mouse, Rat	immunogen = highly purified peptide D P E A Q R R V P K N P K Y corresp. to aa 303-316 from the loop region of mouse presenilin 1	detects presenilin 1 (dimer at 98kDa and endo-proteolytic frag at 21kDa)	-
	Presenilin-2	Calbiochem EMD Biosciences	polyclonal IgG	Rabbit (liquid, affinity purified, PBS, azide, gelatin)	-	Human, Mouse, Rat	immunogen = aa 7-24 from the N-terminus of human PS2	detects N-terminal proteolytic fragment at 28 kDa in WB	-
	Presenilin-2, loop domain	Calbiochem EMD Biosciences	polyclonal IgG	Rabbit (liquid, undiluted serum, no preservative)	-	Human, Mouse	immunogen = recomb. protein containing the loop domain (aa 269-394) of human presenilin-2 fusedto GST	detects full-lengthpresenilin 2 and its C-terminal fragments	-
	Presenilin-1	Sigma Aldrich	polyclonal IgG	Rabbit (liquid, PBS, azide, gelatin)	-	Mouse, Rat	immunogen = highly purified peptide D S Q E R Q Q Q H D R Q R L D N corresp. to aa 31-46 from the N-terminal region of mouse presenilin 1	detects presenilin 1 (dimer at 98kDa and enodproteolytic frag at 30kDa)	-
	Presenilin-1	Sigma Aldrich	polyclonal	Rabbit (liquid, buffered aqueous solution, affinity isolated, PBS, azide)	-	Human, Mouse, Rat	immunogen = a 23 amino acid peptide from near the carboxy-terminus of human presenilin1	detects presenilin 1	-
	Presenilin-1, C-Terminal	Sigma Aldrich	polyclonal IgG	Rabbit (liquid, PBS, azide, purified)	-	Human, Mouse, Rat, Xenopus	immunogen = synthetic peptide (K-D Y L V Q P F M D Q L A F H Q F Y I) corresp. to C-terminal of human presenilin 1 (aa 450-467 with N-terminal added lysine), conj. to KLH	detects presenilin 1, 48 kDa (and a degredation product at ~18kDa); stains neurite plaques in AD brain	-
	Presenilin-1, NT	Sigma Aldrich	polyclonal	Goat (liquid, whole serum, azide)	-	Human	immunogen = purified peptide corresp. to aa 14-33 of presenilin 1	recognizes presenilin 1	-
	Presinilin-1, CT	Anaspec	polyclonal IgG	Rabbit (liquid, affinity purified, PBS, azide)	-	Human, Mouse, Rat	immunogen = a 23 amino acid peptide from near the carboxy terminus of human Presenilin1	recognizes presenilin-1	-
	Presinilin-1, NT	Anaspec	polyclonal	Rabbit (liquid, affinity purified, PBS, BSA, azide)	-	Human	immunogen = a synthetic peptide derived from the N-terminus of human presenilin 1 protein	recognizes presenilin-1	-
	Presinilin-1	Anaspec	polyclonal IgY	Chicken (liquid, affinity purified, PBS, azide)	-	Human, Mouse, Rat	immunogen = a mixture of two peptides from human presenilin-1	recognizes presenilin-1	-
	Presinilin enhancer protein-2 /PEN2, NT	Anaspec	polyclonal IgG	Rabbit (liquid, affinity purified, PBS, azide)	-	Human, Mouse, Rat	immunogen = a 13 amino acid peptide from near the N-terminus of human PEN2	recognizes PEN2	-
	Presinilin enhancer protein-2 /PEN2, CT	Anaspec	polyclonal IgG	Rabbit (liquid, affinity purified, PBS, azide)	-	Human, Mouse, Rat	immunogen = a 13 amino acid peptide from near the C-terminus of human PEN2	recognizes PEN2	-
	Presenilin-1, loop (PS1-loop)	Chemicon and Upstate are Millipore	monoclonal IgG1	Mouse (liquid, ascites, no preservative)	-	Primate (various), Mouse, Rat	immunogen = Presenilin-1, loop fusion protein, C-terminal (amino acids 263-378), human	Presenilin-1, loop.	-
	PEN2	Abcam	polyclonal IgG	Rabbit (liquid, affinity purified, PBS, azide)	-	Human, Mouse, Rat	immunogen = synthetic peptide (Human) of 13 amino acids from near the C-terminus of PEN2	detects Carboxy terminal end of PEN2 protein	-
	Aph-1a	Zymed/ Invitrogen	polyclonal	Rabbit (liquid, PBS, azide, affinity purified)	-	Human, Mouse	immunogen = synthetic peptide derived from the C-terminal region of human Aph-1a	Aph-1a (~23kDa) long isoform only	-
	Nicastrin	A B R - Thermo Scientific	polyclonal IgG	Rabbit (epitope affinity purified IgG, PBS, BSA, azide)	-	Human, Mouse	immunogen = synthetic peptide corr. to aa 688-708 of human nicastrin; one aa substitution between human and mouse sequence	Nicastrin in tissues and cells; ~110 kDa in WB	-
	Nicastrin	A B R - Thermo Scientific	polyclonal IgG	Rabbit (liquid, PBS, azide)	-	Human, Mouse, Rat	immunogen = a 18 amino acid peptide sequence near the internal region of human nicastrin	detects Nicastrin	-
	Nicastrin	A B R - Thermo Scientific	polyclonal IgG	Rabbit (liquid, PBS, azide)	-	Human, Mouse, Rat	immunogen = a 17 amino acid peptide sequence near the carboxy terminus of human nicastrin	detects Nicastrin	-
	PEN2	A B R - Thermo Scientific	polyclonal	Rabbit (liquid, serum, azide)	-	Human	immunogen = synthetic peptide corresp. to aa residues F Q I Y R P R W G A L G D Y L S F T I P L G T P of human Pen2	Pen-2	-
	PEN2	A B R - Thermo Scientific	polyclonal	Rabbit (liquid, PBS, azide)	-	Human, Mouse, Rat	immunogen = a 13 amino acid peptide sequence near the amino terminus of human PEN2.	detects Pen-2, N-terminal	-
	PEN2	A B R - Thermo Scientific	polyclonal IgG	Rabbit (IgG affinity purified, lyophilized)	-	Human, Hamster, Mouse	immunogen = a synthetic peptide, conjugated to KLH, corresponding to the 11 most N-terminal residues of human Pen-2	detects Pen-2	-
	APH-1	A B R - Thermo Scientific	polyclonal	Rabbit (liquid, affinity purified, PBS, BSA, azide, glycerol)	-	Human, Mouse	immunogen = Synthetic peptide, KLH conjugated, corresponding to residues C(245)RRQEDSRVM VYSALRIPPED(265) of human APH-1aL/C-terminal	recognizes APH-1	-
	Nicastrin	Sigma Aldrich	polyclonal	Rabbit (buffered aqueous solution , IgG fract, PBS, azide)	-	Human	immunogen = synthetic peptide corr to C-terminus, aa 693-709 of human nicastrin, conj. to KLH	detects Nicastrin	-
	Presenilin-1 NTF (Ln-14)	Santa Cruz	monoclonal IgG2b	Mouse (liquid, PBS, azide, protein stabilizer)	-	Human	immunogen = amino acids 1-80 of Presenilin 1 of human origin	for detection of Presenilin 1 NTF subunit of human origin; no cross with Presenilin 2 or Presenilin 1 CTF subunit	-
	Aph-1aL C-Terminal	BioLegend	polyclonal	Rabbit (liquid, affinity purified)	-	Human	immunogen = human Aph-1aL/ C-terminal region sequence C R R Q E D S R V M V Y S A L R I P P E D	Aph-1aL	Available from BioLegend
	Presenilin-2, C-Terminal	Calbiochem EMD Biosciences	polyclonal IgG	Rabbit (affinity purified IgG, PBS, azide, gelatin)	-	Human, Mouse, Rat	synthetic peptide (EEDSYDSFGEPS) corr. to aa 324-335 from the C-terminus of human PS2	detects ~20 kDa proteolytic fragment of presenilin-2	-
	Presenilin-1	Calbiochem EMD Biosciences	polyclonal IgG	Rabbit (liquid, purified, PBS, azide, gelatin or glycerol)	-	Mouse, Rat	immunogen = aa 31-46 of N-terminus of mouse PS-1	recognizes the ~98 kDa presenilin-1 dimer.	-
	Presenilin-1	Calbiochem EMD Biosciences	polyclonal IgG	Rabbit (liquid, purified, PBS, azide, gelatin)	-	Mouse, Rat	immunogen = synthetic peptide corrsp. to aa 303-316 of the intracellular loop region of mouse PS-1	~98k Presenilin-1 dimer	-
	Presenilin-1	Calbiochem EMD Biosciences	polyclonal IgG	Goat (liquid, undiluted serum, azide)	-	Human	immunogen = synthetic peptide corresp. to aa 14-33 of human presenilin-1	presenilin-1 protein	-
	Presenilin-1, loop	Calbiochem EMD Biosciences	polyclonal IgG	Rabbit (liquid, undiluted serum, no preservative)	-	Human, Monkey, Mouse, Rat	immunogen = recomb. protein containing the loop domain (aa 263-407) of human presenilin 1 fusedto GST	Recognizes full-lengthpresenilin 1 and its C-terminal fragments	-
	Presenilin-1	A D I	polyclonal IgG	Rabbit (affinity purified with PBS, BSA and merthiolate)	-	Human, Mouse, Rat, Xenopus	immunogen = a 15 mer peptide (PS11-P) locating to the large hydrophilic loop of human or mouse Presenilin-1	Presenilin-1	-
	Presenilin-1	A D I	polyclonal	Rabbit (unpurified antiserum)	-	Human, Mouse, Rat, Xenopus	immunogen = a 15 mer peptide (PS11-P) locating to the large hydrophilic loop of human or mouse Presenilin-1	Presenilin-1	-
	Presenilin-1	A D I	polyclonal	Goat (unpurified antiserum)	-	Human	immunogen = a 20-aa peptide from human Presenilin-1, at the N-terminus, extracellular region	Presenilin-1; no cross with PS2 or other known proteins	-
	Presenilin-2	A D I	polyclonal IgG	Rabbit (affinity purified with PBS, BSA and merthiolate)	-	Human, Mouse, Rat	immunogen = a 18 mer peptide (PS21-P) locating near the amino terminus of Presenilin-2	Presenilin-2	-
	Presenilin-2	A D I	polyclonal	Rabbit (unpurified antiserum)	-	Human, Mouse, Rat	immunogen = a 18 mer peptide (PS21-P) locating near the amino terminus of Presenilin-2	Presenilin-2	-
	Presenilin-1	BioVision	polyclonal IgG	Rabbit (liquid, affinity purified, PBS, glycerol, BSA, azide)	-	Human, Mouse, Rat	immunogen = synthetic peptide surrounding amino acid 296 of human Presenilin 1	Presenilin-1	-
	Presenilin-2	BioVision	polyclonal	Rabbit (liquid, PBS, glycerol, BSA, thimerosal, affinity purified)	-	Human, Mouse, Rat	immunogen = synthetic peptide surrounding amino acid 333 of human presenilin 2	Presenilin-2	-
	Nicastrin	Vinci Biochem	polyclonal IgG	Rabbit (epitope affinity purified IgG, PBS, BSA, azide)	-	Human, Mouse	immunogen = synthetic peptide corr. to aa 688-708 of human nicastrin; one aa substitution between human and mouse sequence	Nicastrin in tissues and cells; ~110 kDa in WB	-
	Presenilin-1, loop	VWR International, Inc.	monoclonal IgG1	Mouse (liquid Ig, purified, PBS, azide)	-	Primate (various), Human, Mouse, Rat	aa 263-378 of  Presenilin-1, loop fusion protein	Presenilin-1, loop.	-
	Presenilin-2, C-Terminal	VWR International, Inc.	polyclonal IgG	Rabbit (affinity purified IgG, PBS, azide, gelatin)	-	Human, Mouse, Rat	synthetic peptide corr. to aa 324-335 from the C-terminus of human PS2	~20 kDa proteolytic fragment of presenilin-2	-
	Presenilin-1 (MPS1-NT)	VWR International, Inc.	monoclonal IgG2a	Rat (liquid, supernatant, no preservative)	-	Human	N-terminal of human PS-1 aa 21-80 fused to GST	neuritic component of senile plaques as well as in neurofibrillary tangles	-
	Presenilin 1	VWR International, Inc.	polyclonal	Rabbit (serum, liquid, PBS, azide)	-	Human, Monkey, Hamster, Mouse	aa 275-367 of human PS1 fused to C-terminus of maltose binding protein	Presenilin 1, loop	-
	Nicastrin (35)	BD Transduction	monoclonal IgG2a	Mouse (liquid, PBS, BSA, glycerol, azide)	-	Dog, Chicken, Human, Mouse, Rat	immunogen = peptide corresp. to aa 168-289 from human nicastrin	nicastrin (~110 kDa)	-
	Presenilin-1, N-terminal	Calbiochem EMD Biosciences	polyclonal IgG	Rabbit (liquid, undiluted serum, no preservative)	-	Human, Monkey, Mouse, Rat	immunogen = recomb. protein containing aa 1-65 of human presenilin 1 fused to GST	Recognizes the presenilin 1 (1-65) holoprotein and its N-terminal fragments	-