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Antibodies

853 Results

Name Source Clonality &
Isotype		 Host &
Formulation		 Method Reactivity Immunogen/
Epitope		 Specificity Availability
γ-secretase/ Presenilins From manufacturers (100)
ABGENT polyclonal
 Rabbit
(liquid, PBS, azide, protein G purified)		 ELISA, IH Human immunogen = synthetic peptide (10-30 aa in length) at the N-term of first 50 aa of human Ubiquilin3, conj. to KLH ubiquilin3 -
ABGENT polyclonal
 Rabbit
(liquid, PBS, azide, protein G purified)		 ELISA, IH, WB Human immunogen = synthetic peptide (10-30 aa in length) at the C-term of last 50 aa of human Ubiquilin 3, conj. to KLH ubiquilin3 -
Abnova Corporation polyclonal
 Mouse
(liquid, glycerol)		 ELISA, WB - immunogen = NCSTN (AAH47621, 16 a.a. ~ 115 a.a) partial recombinant protein with GST tag; GenBank Acc# BC047621 Nicastrin -
Abnova Corporation monoclonal
IgG1		 Mouse
 ELISA - immunogen = PSENEN (AAH09575, 1 a.a. ~ 102 a.a) full length recombinant protein with GST tag Pen2 -
Abnova Corporation polyclonal
 Mouse
(liquid, glycerol)		 ELISA, WB - immunogen = PSENEN (AAH09575, 1 a.a. ~ 102 a.a) full length recombinant protein with GST tag Pen2 -
Abnova Corporation monoclonal
IgG1		 Mouse
(liquid)		 ELISA - immunogen = UBQLN1 (AAH39294, 1 a.a. ~ 590 a.a) full length recombinant protein with GST tag ubiquilin1 -
Abnova Corporation monoclonal
IgG2a		 Mouse
(liquid)		 WB Mouse, Rat immunogen = UBQLN2 (NP_038472, 555 a.a. ~ 625 a.a) partial recombinant protein with GST tag. ubiquilin2 -
Acris Antibodies polyclonal
IgG		 Rabbit
(liquid, PBS, BSA, azide, affinity purified)		 Neut, WB Human, Mouse immunogen = synthetic peptide, C I N A K A D V L F I A P R E P G A V S Y, corresp. to aa 688-708 from human nicastrin nicastrin (~110kDa) -
Acris Antibodies polyclonal
IgG		 Rabbit
(liquid, PBS, BSA, glycerol, azide, affinity purified)		 IF, IP, WB Human, Mouse immunogen = peptide, C R R Q E D S R V M V Y S A L R I P P E D, corresp. to aa 245-265 at C-terminal domain of the long isoform of human Aph-1a, conj. to KLH Aph-1 -
Acris Antibodies polyclonal
IgG		 Rabbit
(liquid, PBS, BSA, azide)		 WB Human, Mouse immunogen = synthetic peptide, C I N A K A D V L F I A P R E P G A V S Y corresp. to aa 688-708 from human nicastrin Nicastrin (~110kDa) -
Acris Antibodies polyclonal
IgG		 Rabbit
(liquid, affinity purified)		 ELISA, IH, WB Human immunogen = 19aa peptide from C-terminus of human nicastrin, conj. to KLH nicastrin (~80kDa) -
Acris Antibodies polyclonal
 Rabbit
(liquid, unpurified serum)		 ELISA, IH, WB Human immunogen = 19aa peptide from the C-terminus of human nicastrin conj to KLH nicastrin (~80kDa) -
Acris Antibodies polyclonal
 Rabbit
(liquid, NEAT serum)		 IP, WB Human, Mouse immunogen = synthetic peptide corresp. to aa residues F Q I Y R P R W G A L G D Y L S F T I P L G T P Pen2 (~12kDa) -
Acris Antibodies polyclonal
IgG		 Rabbit
(liquid, PBS, BSA, azide, affinity purified)		 WB Hamster immunogen = synthetic peptide A E S A E S G G P P G A Q D S A A corresp. to aa residues 2-18 from mouse ubiquilin Ubiquilin (~63kDa) -
Axxora polyclonal
IgG		 Rabbit
(liquid, PBS, BSA, azide, affinity purified)		 WB Human, Mouse immunogen = synthetic peptide corresp. to aa 688-708 (C I N A K A D V L F I A P R E P G A V S Y) of human nicastrin nicastrin (~110kDa) -
Axxora polyclonal
 Rabbit
(frozen, PBS, purified, concentrated)		 IP, WB Human immunogen = synthetic peptide corresp. to aa 698-709 of human nicastrin nicastrin -
A D I polyclonal
IgG		 Rabbit
(liquid, affinity purified)		 ELISA, IH, WB Human immunogen = 19aa peptide from C-terminus of human nicastrin, conj. to KLH nicastrin (~80kDa) -
A D I polyclonal
 Rabbit
(liquid, unpurified serum)		 ELISA, IH, WB Human immunogen = 19aa peptide from the C-terminus of human nicastrin conj to KLH nicastrin (~80kDa) -
AMS Biotechnology polyclonal
 Rabbit
(liquid, PBS, azide, protein G purified)		 ELISA Human immunogen = synthetic peptide, 10-30 aa, at the N-term of first 110 aa of human APH1, conj. to KLH Aph1 -
AMS Biotechnology polyclonal
 Rabbit
(liquid, PBS, azide, protein G purified)		 ELISA Human immunogen synthetic peptide, 10-30 aa, at the C-term of last 50 aa of human APH1 Aph1 -
AMS Biotechnology polyclonal
IgG		 Rabbit
(liquid, protein-A purified, PBS, no preservative)		 IP, WB Human immunogen = synthetic peptide corr. to aa residues 689-709 at C-terminus of nicastrin reacts with nicastrin protein -
AMS Biotechnology polyclonal
 Rabbit
(liquid, PBS, azide, protien G purified)		 ELISA Human immunogen = synthetic peptide, 10-30 aa, at the N-term of first 50 aa of human PEN2, conj. to KLH Pen2 -
AMS Biotechnology polyclonal
 Rabbit
(liquid, PBS, azide, protein G purified)		 ELISA Human immunogen = synthetic peptide, 10-30 aa, at the N-term of first 60 aa of human PEN2 Pen2 -
AMS Biotechnology polyclonal
 Rabbit
(liquid, PBS, azide, protein G purified)		 ELISA Human immunogen = synthetic peptide (10-30 aa) at the N-term of first 100 aa of human PEN2, conj. to KLH Pen2 -
AMS Biotechnology polyclonal
 Rabbit
(liquid, PBS, azide)		 ELISA Human immunogen = synthetic peptide selected from the N-terminal region of human PEN2, conj. to KLH Pen2 -
AMS Biotechnology polyclonal
 Rabbit
(liquid, Ig fraction, PBS, azide)		 ELISA Human immunogen = synthetic peptide selected from the center region of human PEN2, conj. to KLH Pen2 -
AMS Biotechnology polyclonal
 Rabbit
(liquid, PBS, azide, protein G purified)		 ELISA, WB Human, Mouse immunogen = synthetic peptide (10-30 aa in length) at the N-term of first 100 aa of human Ubiquilin1, conj. to KLH ubiquilin1 -
AMS Biotechnology polyclonal
 Rabbit
(liquid, PBS, azide, protein G purified)		 ELISA, IH, WB Human, Mouse immunogen = synthetic peptide (10-30 aa in length) in the region of 336~351 of human Ubiquilin, conj. to KLH ubiquilin1 -
AMS Biotechnology polyclonal
 Rabbit
(liquid, PBS, azide, protein G purified)		 ELISA, IH Human immunogen = synthetic peptide (10-30 aa in length) at the N-term of first 50 aa of human Ubiquilin3, conj. to KLH ubiquilin3 -
AMS Biotechnology polyclonal
 Rabbit
(liquid, PBS, azide, protein G purified)		 ELISA, IH, WB Human immunogen = synthetic peptide (10-30 aa in length) at the C-term of last 50 aa of human Ubiquilin 3, conj. to KLH ubiquilin3 -
Autogen Bioclear polyclonal
IgG		 Rabbit
(liquid, affinity purified)		 ELISA, IH, WB Human immunogen = 19aa peptide from C-terminus of human nicastrin, conj. to KLH nicastrin (~80kDa) -
Autogen Bioclear polyclonal
 Rabbit
(liquid, unpurified serum)		 ELISA, IH, WB Human immunogen = 19aa peptide from the C-terminus of human nicastrin conj to KLH nicastrin (~80kDa) -
Biotrend polyclonal
IgG		 Rabbit
(IgG fraction, liquid, affinity purified)		 ELISA, IH, WB Human immunogen = 19aa peptide from C-terminus of human nicastrin, conj. to KLH nicastrin (~80kDa) -
Biotrend polyclonal
 Rabbit
(antiserum)		 ELISA, IH, WB Human immunogen = 19aa peptide from the C-terminus of human nicastrin conj to KLH nicastrin (~80kDa) -
Calbiochem EMD Biosciences polyclonal
IgG		 Rabbit
(liquid, NEAT serum)		 IP, WB Human, Mouse, Rat immunogen = synthetic peptide (C R R Q E D S R V M V Y S A L R I P P E D) corresp. to aa 245-265 of human and mouse Aph-1aL Aph-1aL protein (~30kDA) -
Calbiochem EMD Biosciences polyclonal
IgG		 Rabbit
(liquid, neat serum)		 IP, WB Human, Mouse immunogen = synthetic peptide (M N L E R R S N E E K L N L C R K Y Y L G G F A F L) corresp. to aa 1-26 of human PEN-2 PEN-2 integral membrane protein (~10kDa) -
Calbiochem EMD Biosciences polyclonal
IgG		 Rabbit
(liquid, PBS, BSA, azide, affinity purified)		 WB Mouse immunogen = synthetic peptide (A E S A E S G G P P G A Q D S A A) corresp. to aa 2-18 of mouse ubiquilin ubiquilin (~63kDa) -
CEDARLANE Laboratories polyclonal
IgG		 Rabbit
(IgG fraction, liquid, affinity purified)		 ELISA, IH, WB Human immunogen = 19aa peptide from C-terminus of human nicastrin, conj. to KLH nicastrin (~80kDa) -
CEDARLANE Laboratories polyclonal
 Rabbit
(antiserum)		 ELISA, IH, WB Human immunogen = 19aa peptide from the C-terminus of human nicastrin conj to KLH nicastrin (~80kDa) -
Biotrend polyclonal
IgG		 Rabbit
(liquid, Ig fraction)		 ELISA, IH, IP, WB Human immunogen = affinity purified human PS-1 Presenilin-1 -
Biotrend polyclonal
 Rabbit
(liquid, antiserum)		 - Human - Presenilin-1 -
Biotrend monoclonal
 Mouse
(liquid, ascites)		 - Human - Presenilin-1 -
Biotrend polyclonal
 Goat
(liquid, antiserum)		 - Human - Presenilin-1 -
Biotrend polyclonal
 Rabbit
(liquid, antiserum)		 - Human - Presenilin-2 -
Biotrend polyclonal
 Rabbit
(IgG fraction)		 - Human - Presenilin-2 -
Euromedex polyclonal
IgG		 Rabbit
(liquid, PBS, azide, glycerol, affinity purified)		 IP, WB Human, Mouse immunogen = synthetic peptide derived from the C-terminal region of human Aph-1a Aph-1a long isoform only(~29kDa, fragment at ~23kDa) -
Euromedex polyclonal
 Mouse
(liquid, glycerol)		 ELISA, WB - immunogen = NCSTN (AAH47621, 16 a.a. ~ 115 a.a) partial recombinant protein with GST tag; GenBank Acc# BC047621 nicastrin -
Euromedex polyclonal
 Rabbit
(liquid, affinity purified)		 IH, WB Human immunogen = synthetic peptide from the C-terminus of human Nicastrin Nicastrin (~100-130kDa and ~35kDa) -
Euromedex polyclonal
 Rabbit
(liquid, HEPES, NaCl, BSA, glycerol, affinity purified)		 WB Human immunogen = synthetic peptide (KLH coupled) corresp. to residues surrounding the C-terminus of human Nicastrin endogenous levels of nicastrin -
Euromedex polyclonal
IgG		 Guinea Pig
(liquid, serum, no preservative)		 IH, WB Rat immunogen = synthetic peptide corresp. to the mouse Nicastrin protein nicastrin -
Euromedex polyclonal
IgG		 Rabbit
(liquid, neat serum, glycerol)		 ELISA, WB Human immunogen = 19 aa synthetic peptide within the C-terminus of human nicastrin, coupled to KLH nicastrin -
Euromedex polyclonal
 Rabbit
(liquid, PBS, azide, glycerol, affinity purified)		 ELISA, WB Human immunogen = 19 aa peptide within the C-terminus of human nicastrin, coupled to KLH nicastrin -
Euromedex monoclonal
IgG1		 Mouse
(liquid)		 ELISA - immunogen = UBQLN1 (AAH39294, 1 a.a. ~ 590 a.a) full length recombinant protein with GST tag ubiquilin1 -
Euromedex polyclonal
 Mouse
(liquid, glycerol)		 - - immunogen = UBQLN1 (AAH39294, 1 a.a. ~ 590 a.a) full length recombinant protein with GST tag ubiquilin1 -
Europa polyclonal
IgG		 Rabbit
(liquid, PBS, azide, glycerol, affinity purified)		 IP, WB Human, Mouse immunogen = synthetic peptide derived from the C-terminal region of human Aph-1a Aph-1a Long form only (~29kD, fragment at ~23kD) -
Europa polyclonal
 Rabbit
(liquid, affinity purified)		 IH, WB Human immunogen = synthetic peptide from the C-terminus of human Nicastrin nicastrin -
Europa polyclonal
 Rabbit
(liquid, PBS, BSA, azide, affinity purified)		 WB Human, Mouse immunogen = synthetic peptide corresp. to aa 688-708 (C I N A K A D V L F I A P R E P G A V S Y) of human nicastrin nicastrin (~110kDa) -
Europa polyclonal
 Rabbit
(liquid, HEPES, NaCl, BSA, glycerol, affinity purified)		 WB Human immunogen = synthetic peptide (KLH coupled) corresp. to residues surrounding the C-terminus of human Nicastrin endogenous levels of nicastrin -
Europa polyclonal
 Rabbit
(liquid, PBS, azide, affinity purified)		 ELISA, WB Human immunogen = synthetic peptide derived from the C-terminal region of the human nicastrin protein nicastrin (~110kDa) -
Europa polyclonal
IgG		 Guinea Pig
(liquid, serum, no preservative)		 IH, WB Rat immunogen = synthetic peptide corresp. to the mouse Nicastrin protein nicastrin -
Europa polyclonal
IgG		 Rabbit
(liquid, neat serum, glycerol)		 ELISA, WB Human immunogen = 19 aa synthetic peptide within the C-terminus of human nicastrin, coupled to KLH nicastrin -
Europa polyclonal
 Rabbit
(liquid, PBS, azide, glycerol, affinity purified)		 ELISA, WB Human immunogen = 19 aa peptide within the C-terminus of human nicastrin, coupled to KLH nicastrin -
Europa polyclonal
 Rabbit
(liquid, PBS, azide, affinity purified)		 IH, IP, WB Human, Mouse immunogen = synthetic peptide derived from the N-terminal region of the human and mouse Pen-2 proteins Pen-2 (~14kDa, also bands of unknown origin between ~30 and 100kD) -
Europa monoclonal
IgG1		 Mouse
(liquid, PBS, azide protein A purified)		 ELISA, WB Human immunogen = recombinant protein corresponding to the C-terminal region of the human ubiquilin protein ubiquilin (~66kDa) -
Europa monoclonal
IgG2b,κ		 Mouse
(liquid, PBS, azide, protein A purified)		 ELISA, IP, WB Human immunogen = recombinant protein derived from an internal region of human ubiquilin ubiquilin (~66kDa) -
GeneTex polyclonal
IgG		 Rabbit
(liquid, PBS, BSA, azide, affinity purified)		 WB Human, Mouse immunogen = synthetic peptide (A D E G L A S L S E D G R S P I S I R), conjugated to KLH, corresp. to C-terminal aa 97-115 of human APH1a recognises both isoforms of APH1a (encoded on chromosome 1) -
GeneTex polyclonal
IgG		 Rabbit
(liquid, PBS, glycerol, PBS, azide, affinity purified)		 IF, IP, WB Human, Mouse immunogen = synthetic peptide (C R R Q E D S R V M V Y S A L R I P P E D corresp. to C-terminal domain of the long isoform of aa 245-265 of human APH1a, conj. to KLH Anterior Pharynx Defective 1 (APH1a) -
GeneTex polyclonal
IgG		 Rabbit
(liquid, PBS, BSA, azide, affinity purified)		 WB Human, Mouse immunogen = synthetic Peptide ( C I N A K A D V L F I A P R E P G A V S Y) peptide corresponds to aa residues 688-708 from human Nicastrin nicastrin -
GeneTex polyclonal
IgG		 Rabbit
(liquid, serum, azide)		 IP, WB Human immunogen = synthetic peptide (F Q I Y R P R W G A L G D Y L S F T I P L G T P) corresp. to aa 78-101 of human PEN2 Pen2 -
GeneTex polyclonal
IgG		 Rabbit
(liquid, PBS, BSA, azide, affinity purified)		 WB Hamster, Mouse immunogen = synthetic peptide (A E S A E S G G P P G A Q D S A A) corresp. to aa 2-18 of mouse Ubiquilin ubiquilin (~63kDa) -
Histo-Line polyclonal
 Rabbit
(liquid, PBS, azide, affinity purified)		 IP, WB Human, Mouse immunogen = synthetic peptide derived from the C-terminal region of human Aph-1a Aph-1a (~23kDa) long isoform only -
Histo-Line polyclonal
 Rabbit
(liquid, PBS, azide, affinity purified)		 WB Human, Mouse immunogen = synthetic peptide derived from the C-terminal region of the human nicastrin protein nicastrin (~110 kDa; bound nicastrin ~150kDa) -
Histo-Line polyclonal
 Rabbit
(liquid, PBS, azide, affinity purified)		 IH, IP, WB Human, Mouse immunogen = synthetic peptide derived from the N-terminal region of the human and mouse Pen-2 proteins Pen-2 (~14 kDa) -
Histo-Line monoclonal
IgG2b,κ		 Mouse
(liquid, PBS, azide, protein A purified)		 IP, WB Human immunogen = recombinant protein derived from an internal region of human ubiquilin ubiquilin (~66kDa) -
ID Labs Biotechnology polyclonal
 Unknown Host
 - - - - -
Insight Biotechnology polyclonal
IgG		 Rabbit
(liquid, PBS, BSA, glycerol, azide, affinity purified)		 IF, IP, WB Human, Mouse immunogen = peptide, (C R R Q E D S R V M V Y S A L R I P P E D), corresp. to aa 245-265 from the human Aph-1aL/CT, conj. to KLH Aph-1 -
Insight Biotechnology polyclonal
IgG		 Rabbit
(liquid, PBS, BSA, azide, affinity purified)		 Neut, WB Human, Mouse immunogen = synthetic peptide, C I N A K A D V L F I A P R E P G A V S Y, corresp. to aa 688-708 from human nicastrin nicastrin (~110kDa) -
Insight Biotechnology polyclonal
IgG		 Rabbit
(liquid, affinity purified)		 ELISA, IH, WB Human immunogen = 19aa peptide from C-terminus of human nicastrin, conj. to KLH nicastrin (~80kDa) -
Insight Biotechnology polyclonal
 Rabbit
(liquid, unpurified serum)		 ELISA, IH, WB Human immunogen = 19aa peptide from the C-terminus of human nicastrin conj to KLH nicastrin (~80kDa) -
Insight Biotechnology polyclonal
IgG		 Goat
(liquid, PBS, azide, gelatin, affinity purified)		 IF, WB Human immunogen = peptide mapping at the N-terminus of PEN-2 of human origin. PEN-2 -
Insight Biotechnology polyclonal
IgG		 Rabbit
(liquid, PBS, BSA, azide, affinity purified)		 WB Hamster immunogen = synthetic peptide A E S A E S G G P P G A Q D S A A corresp. to aa residues 2-18 from mouse ubiquilin Ubiquilin (~63kDa) -
Interchim polyclonal
 Rabbit
(liquid, PBS, azide, protein G purified)		 ELISA Human immunogen synthetic peptide, 10-30 aa, at the C-term of last 50 aa of human APH1 Aph-1 -
Interchim polyclonal
 Rabbit
(liquid, PBS, azide, protein G purified)		 ELISA - immunogen = synthetic peptide, 10-30 aa, at the N-term of first 110 aa of human APH1, conj. to KLH Aph-1 -
Interchim polyclonal
 Rabbit
(liquid, protein-A purified, PBS, no preservative)		 IP, WB Human immunogen = synthetic peptide corr. to aa residues 689-709 at C-terminus of nicastrin nicastrin -
Interchim polyclonal
 Guinea Pig
(Liquid, serum, no preserve)		 IH, WB Rat immunogen = synthetic peptide corresponds to aa 690-708 of mouse nicastrin Nicastrin in neural cell bodies in hippocampal formation, cerebral cortex, thalamic nuclei, Purkinje cells of the cerebellum, motoneurons in the brainstem and spinal cord -
Interchim polyclonal
 Rabbit
(liquid, affinity purified)		 IH, WB Human immunogen = synthetic peptide from the C-terminus of human Nicastrin nicastrin -
Interchim polyclonal
IgG		 Rabbit
(liquid, affinity purified, PBS, BSA, azide)		 WB Human, Mouse immunogen = synthetic peptide (I N A K A D V L F I A P R E P G A V S Y corr. to C-terminal aa 688-708 from human nicastrin ~110 kDa nicastrin -
Interchim polyclonal
 Rabbit
(affinity purified)		 - - - - -
Li Starfish polyclonal
IgG		 Rabbit
(liquid, PBS, BSA, glycerol, azide, affinity purified)		 IF, IP, WB Human, Mouse immunogen = peptide, C R R Q E D S R V M V Y S A L R I P P E D, corresp. to aa 245-265 at C-terminal domain of the long isoform of human Aph-1a, conj. to KLH Aph-1 -
Li Starfish polyclonal
IgG		 Rabbit
(liquid, PBS, BSA, azide, affinity purified)		 Neut, WB Human, Mouse immunogen = synthetic peptide, C I N A K A D V L F I A P R E P G A V S Y, corresp. to aa 688-708 from human nicastrin nicastrin (~110kDa) -
Li Starfish polyclonal
IgG		 Rabbit
(liquid, affinity purified)		 ELISA, IH, WB Human immunogen = 19aa peptide from C-terminus of human nicastrin, conj. to KLH nicastrin (~80kDa) -
Li Starfish polyclonal
 Rabbit
(liquid, unpurified serum)		 ELISA, IH, WB Human immunogen = 19aa peptide from the C-terminus of human nicastrin conj to KLH nicastrin (~80kDa) -
Li Starfish polyclonal
 Rabbit
(liquid, NEAT serum)		 IP, WB Human, Mouse immunogen = synthetic peptide corresp. to aa residues F Q I Y R P R W G A L G D Y L S F T I P L G T P Pen2 (~12kDa) -
Li Starfish polyclonal
IgG		 Rabbit
(liquid, PBS, BSA, azide, affinity purified)		 WB Hamster immunogen = synthetic peptide A E S A E S G G P P G A Q D S A A corresp. to aa residues 2-18 from mouse ubiquilin Ubiquilin (~63kDa) -
Abnova Corporation polyclonal
 Mouse
(liquid, glycerol)		 WB Human immunogen = UBQLN1 (AAH39294, 1 a.a. ~ 590 a.a) full length recombinant protein with GST tag ubiquilin1 -
Sigma Aldrich polyclonal
 Rabbit
(liquid, PBS, azide, affinity purified)		 WB Human immunogen = synthetic peptide encoding aa 86-101 located at the C-terminus of human Pen-2, conj. to KLH Pen-2 (10kDa) -
Signet Covance polyclonal
IgG		 Rabbit
(liquid, purified, PBS, no carrier, no preservative)		 IP, WB Human immunogen = aa 698-709 of nicastrin nicastrin protein -
US Biological polyclonal
IgG		 Rabbit
(liquid, PBS, azide, glycerol, affinity purified)		 IP, WB Human, Mouse immunogen = synthetic peptide derived from the C-terminal region of human Aph-1a Aph-1a long isoform only(~29kDa, fragment at ~23kDa) -
US Biological polyclonal
 Rabbit
(liquid, affinity purified)		 IH, WB Human immunogen = synthetic peptide from the C-terminus of human Nicastrin Nicastrin (~100-130kDa and ~35kDa) -
US Biological polyclonal
 Rabbit
(liquid, PBS, BSA, azide, affinity purified)		 WB Human, Mouse immunogen = synthetic peptide corresp. to aa 688-708 (C I N A K A D V L F I A P R E P G A V S Y) of human nicastrin nicastrin (~110kDa) -