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Antibodies

572 Results

Name Source Clonality &
Isotype
Host &
Formulation
Method Reactivity Immunogen/
Epitope
Specificity Availability
Tau From labs (22)
Peter Davies, Department of Pathology, Albert Einstein College of MedicineReference: Roberson, 2007 monoclonal
IgG2b
Mouse
IB, IH Human, Mouse, Rat epitope around phospho Threonine231 tau phospho. at Thr231 -
Tau-001(Peter Davies, Department of Pathology, Albert Einstein College of Medicine)References: Paquet, 2009Eckermann, 2007Shahani, 2006Götz, 2001Wittmann 2001 monoclonal
IgG1
Mouse
IC, IF, IH, IP, WB Human, Mouse conformation dependent antibody (epitope within aa 312-322) reactivity depends on both the N terminus (amino acids 7–9), and an amino acid sequence of tau (amino acids 313–322) in the third microtubule binding domain. Recognizes neurofibrillary tangles but does not react with FAC1 -
(Taizo Taniguchi, DirectorBehavioral and Medical Science Research Consortium, Hyogo, Japan) monoclonal
Mouse
(supernate, gel filtered)
Block, EM - raised against human tau (epitope = first repeat of MBD, aa 257-274) binds CHO-R3tau and CHO-R4tau; inhibits PHF formation in human tau, completly blocks in vitro 3RMBD and 4RMBD aggregation -
Peter Davies, Department of Pathology, Albert Einstein College of MedicineReferences:Herskovits, 2006Duff, 2000 monoclonal
IgG2b
Mouse
- Human, Mouse   tau -
Peter Davies, Department of Pathology, Albert Einstein College of MedicinePaper, Jicha GA, et al., 1999Reference: Vingtdeux, 2010 monoclonal
Mouse
IH, WB Human, Mouse immunogen = amino acids around phosphorylated Ser214 recognizes human and murine tau phosphorylated at S214 -
Peter Davies, Department of Pathology, Albert Einstein College of MedicinePaper, Jicha GA, et al., 1999Reference: Vingtdeux, 2010 monoclonal
IgG3
Mouse
ELISA, IH, WB Human, Mouse immunogen = the synthetic phosphopeptides KSPRHLS(P)NV S(P)STGS(P)ID andKSPRHLS(P)NV SS(P)TGSID recognizes the PKA-dependent phosphorylationof ser409 in tau; immunoreactivity with neurofibrillary pathology in both early and advanced Alzheimer’s disease, but not in normal brain tissue; reacts with only PHF and the tau peptide containing phospho ser409 -
Peter Davies, Department of Pathology, Albert Einstein College of MedicineReference: Vingtdeux, 2010 monoclonal
Mouse
- Human, Mouse epitope around phospho Threonine231 highly specific for tau phospho. at Thr231 -
MC6(Gregory Jicha, Departments of Pathology and Neurpscience, Albert Einstein College of Medicine)References:Vingtdeux, 2010Planel, 2008 monoclonal
Mouse
ELISA, IB Human immunogen = affinity purified PHF (epitope around phosphor. Ser235) recognizes tau phosphor. at Ser235; not reactive to non-phosphor. tau.paper Jincha, et al. 1997 -
TauC3(Vincent L. Cryns, Cell Death Regulation Laboratory, Division of Endocrinology,Metabolism, and Molecular Medicine, Northwestern University, Chicago, IL)Research paperReference: Alonso, 2010 monoclonal
IgG1
Mouse
(purified IgG, HEPES, saline, glycerol.)
IF, IH, WB Human immunogen = KLH- C S S T G S I D M V D, corresp. to residues 412-421 at the C-terminus of tau truncated at Asp421 recognizes tau when truncated at Asp421; no reaction with full-length tau, or with tau truncated at Glu391 or Ala429 -
Tau-1(L.I. Binder, Northwestern Univ.)PaperReference: Alonso, 2010 monoclonal
IgG2a
Mouse
ELISA, WB Mouse, Rat   detects Tau that is not phosphorylized at at Ser198/Ser199/Ser202 -
134d(Inge Grundke-Iqbal, Department of Neurochemistry, New YorkState Institute for Basic Research in Developmental Disabilities)research PaperReference: Alonso, 2010 polyclonal
Rabbit
(antiserum)
IH, WB Human immunogen = recombinant human Tau410 recognizes tau in a phosphorylation independent manner -
111e(Khalid Iqbal, Department of Neurochemistry, New YorkState Institute for Basic Research in Developmental Disabilities)research PaperReference: Alonso, 2010 polyclonal
Rabbit
(antiserum)
WB Human - recognizes total tau and hyperphosphorylated tau from AD brain; no cross with bovine tau -
92e(Inge Grundke-Iqbal, Department of Neurochemistry, New YorkState Institute for Basic Research in Developmental Disabilities)research PaperReference: Alonso, 2010 polyclonal
Rabbit
(antiserum)
WB Human - recognizes both phosphorylated and non phosphorylated tau -
Ab708Li Gan, Gladstone Institute of Neurological DiseaseAssistant Professor of NeurologyUniversity of California, San FranciscoReference: Min SW, 2010 polyclonal
IgG2b
Rabbit
WB Human, Rat immunogen = a synthetic tau peptide (amino acids 160–182 for 2N4R tau isoform) containing acetylated lysines at positions 163 and 174 and 180 Ab708 specifically recognizes tau acetylated by p300 under cell-free conditions. In HEK293T cells transfected with tau, overexpression of p300 markedly elevatedthe levels of ac-tau detected with Ab708 while the increase in the levels of t-tau was modest, suggesting that Ab708 preferentially recognizes p300-induced ac-tau in cultured cells. Ab708 recognizes human tau acetylated at positions 163, 174, or 180 and possibly other acetylated lysines on tau, but not nonacetylated tau -
9ABLi Gan, Gladstone Institute of Neurological DiseaseAssistant Professor of NeurologyUniversity of California, San FranciscoReference: Min SW, 2010 polyclonal
Rabbit
WB Human, Mouse immunogen = the microtubule-binding region aa 264–287 (ENLKHQPGGG VQIINKLDLSNV), which is 100% conserved between mouse and human 9AB recognizes recombinant tau acetylated by GST-p300, but not tau incubated with GST alone, suggesting that 9AB does not cross-react with non-ac-tau. 9AB also preferentially recognizes p300-induced ac-tau in cultured cells. In mouse brains, 9AB detected low levels of ac-tau. Does not recognize nonacetylated recombinant tau -
Peter Davies, Department of Pathology, Albert Einstein College of MedicineReference: Zempel H, 2010 monoclonal
IgG1
Mouse
IH Human, Mouse epitope at aa102–140 recognizes total tau -
Peter Davies, Department of Pathology, Albert Einstein College of MedicineReferences:Bhaskar K, 2010Vingtdeux, 2010Polydoro, 2009Adams, 2009Julien, 2008Planel, 2008Luo, 2007Roberson, 2007Herskovits, 2006 monoclonal
IgG2b
Mouse
WB Human epitope around phospho-Serine202 detects tau phosphor. at Serine 202 -
Tau-003(Peter Davies, Department of Pathology, Albert Einstein College of Medicine)References:Bhaskar K, 2010Planel, 2008Götz 2001Lewis, 2001 monoclonal
IgM
Mouse
(IC, IF, IH, IP, WB)
- Human (epitope around phosphor. Thr231); also sensitive to the conformation of the phosphor. tau tau phosphor. at Thr231; not reactive to normal tau; TG3 epitope (phosphorylated Thr231) is expressed in mitotic cells but not in quiescent cells, suggesting that mitotic phosphoepitopes may lead to conformational changes -
Available through Peter Davies. monoclonal
IgM
Mouse
IC, IF, IH, IP, WB - Raised against human basal forebrain homogenate. Epitope subsequently determined to include amino acids 2-10 and 312-342 of tau. Recognizes a misfolded conformation of tau. 68 kDa Tau. Stains neuronal components of AD brain specimens but not normal brain specimens. -
Peter Davies monoclonal
IgG1
Mouse
ELISA, IH, IP, WB Human epitope around Ser396 and Ser404 phosphorylated sites - -
Peter Davies, Department of Pathology, Albert Einstein College of Medicine monoclonal
IgG2b
Mouse
WB Human Human tau 130-150 - -
Philip Dolan, Prothena Biosciences, South San Francisco, CA monoclonal
Mouse
IH, WB Mammal (various), Human, Zebra fish, Drosophila, C. elegans immunogen = tau phosphorylated at S262 in KXGS motif of the 4th repeat and/or Ser356 tau phosphorylated at S262 and/or S356 -
Tau From manufacturers (50)
Affiniti - Biomol polyclonal
IgM,κ
Rabbit
(liquid, antiserum)
IH, WB Human immunogen = a peptide derived from residues 387-436, comprising the UBA domain of p62 detects human 62 kD (p62) protein, found in various neurodegenerative conditions, including tauopathies (Alzheimer’s disease, Picks disease, and frontotemporal dementia) and synucleinopathies (Parkinson’s disease, dementia with Lewy body disease and multiple system atrophy) -
Innogenetics kit
Unknown Host
(solid-phase ELISA, uses monoclonal HT7 for capture, AT270 biotinylated for incubation, streptavidin; working range: 25 to 150 pg/mL)
ELISA Human   specific for tau phosphorylated at threonine 181, antigen in cerebrospinal fluid (CSF) -
Biosource Invitrogen polyclonal
Rabbit
(affinity purified Ig, Dulbecco's PBS, BSA, glycerol, unconjugated)
WB Human chemically synthesized phosphopeptide derived from theregion of human Tau that contains serine 396. detects tau phosphorylated at serine 396; no cross with non phosphorylated tau -
Biosource Invitrogen polyclonal
Rabbit
(purified Ig, Dulbecco’s PBS, BSA, azide, glycerol, unconjugated)
WB Human immunogen = chemically synthesized phosphopeptide derived from the region of human Tau that contains serine 396 tau phosphorylated at serine 396 -
Biosource Invitrogen polyclonal
Rabbit
(purified Ig, PBS, BSA, azide, glycerol, unconjugated)
WB Human tau-derived peptide that is phospho. at serines 199 and 202 tau phosphorylated at serines 199 and 202 -
Biosource Invitrogen polyclonal
Rabbit
(purified Ig, PBS, BSA, azide, glycerol, unconjugated)
ELISA, WB Human immunogen = a chemically synthesized phosphopeptide derived from the region ofhuman Tau that contains serine 199 tau phosphorylated at serine 199 -
Biosource Invitrogen polyclonal
Rabbit
(affinity purified Ig)
ELISA, IH, WB Human immunogen = human tau-derived synthetic peptide that is phosphorylated at serine 202 tau phosphorylated at serine 202 -
Biosource Invitrogen polyclonal
Rabbit
(purified Ig, PBS, BSA, azide, glycerol)
IH, WB Human human tau-derived peptide that is phosphorylated at serine 262 tau phosphorylated at serine 262 -
Biosource Invitrogen polyclonal
Rabbit
(purified Ig, PBS, BSA, azide, glycerol, unconjugated)
WB Human human tau-derived peptide that is phosphorylated at serine 409 tau phosphorylated at serine 409 -
Biosource Invitrogen polyclonal
Rabbit
(purified Ig, PBS, BSA, azide, glycerol, unconjugated)
WB Human human tau-derived peptide that is phosphorylated at threonine 212 tau, tau phosphor. at threonine 212 -
Biosource Invitrogen polyclonal
Rabbit
(purified Ig, PBS, BSA, azide, glycerol, unconjugated)
WB Human human tau-derived peptide that is phosphorylated at threonine 217 tau phosphorylated at threonine 217 -
Biosource Invitrogen polyclonal
Rabbit
(purified Ig, PBS, BSA, azide, glycerol, unconjugated)
WB Human human tau-derived peptide that is phosphorylated at threonine 231 tau phosphorylated at threonine 231 -
Biosource Invitrogen polyclonal
Rabbit
(purified Ig, PBS, BSA, azide, glycerol, unconjugated)
WB Human human tau-derived peptide that is phosphorylated at serine 404 tau phosphorylated at serine 404 -
Biosource Invitrogen polyclonal
Rabbit
(purified Ig, PBS, BSA, azide, glycerol, unconjugated)
WB Human human tau-derived peptide that is phosphorylated at serine 400 tau phosphorylated at serine 400 -
Biosource Invitrogen polyclonal
Rabbit
(liquid, purified Ig, PBS, azide)
WB Human immunogen = synthetic peptide, corresp. to aa residues 186-201 of human tau protein isoform 6 (GEPPKSGDRSG-pY-SSPG), conj. to KLH via an N-terminal cysteine residue detects both non-phosphor. and p56lck-phosphor. tau -
Biosource Invitrogen polyclonal
Rabbit
(liquid, purified Ig, PBS, azide)
IH, WB Human immunogen = synthetic peptide, corresp. to aa residues 384-397 of human tau protein isoform 6 (AKTDHGAEIV-pY-KSP), conj. to KLH via an N-terminal cysteine residue detects both non-phosphor. and p56lck-phosphor. tau -
Biosource Invitrogen polyclonal
Rabbit
(liquid, purified Ig, PBS, azide)
ELISA, IH, WB Human immunogen = synthetic peptide, corresp. to aa residues 384-397 of human tau protein isoform 8 (A K T D H G A E I V -pY- K S P), conjugated to KLH detects both non-phosphor. and p56lck-phosphor. tau -
Biosource Invitrogen polyclonal
Rabbit
(liquid, purified Ig, PBS, azide)
ELISA, IH, WB Human immunogen = synthetic peptide, corresp. to aa residues 186-201 of human tau protein isoform 6 (GEPPKSGDRSG-pY- SSPG), conj. to KLH detects both non-phosphor. and p56lck-phosphor. tau -
Biosource Invitrogen polyclonal
Mouse
(liquid, purified Ig, PBS, azide)
IH, WB Human immunogen = synthetic peptide, corresp. to aa residues 21-36 of human tau protein isoform 6 (GDRKDQGG-pY-TMHQDQE), conj. to KLH detects both non phosphor. and p56lck phosphor. tau -
Biosource Invitrogen monoclonal
IgG1
Mouse
(affinity purified ascites, PBS, BSA, azide, unconj.)
IH, IP, WB Human, Mouse, Rat immunogen = KLH- CSSTGSIDMVD, corresp. to the C-terminus of tau truncated at Asp421 recognizes tau when truncated at Asp421; no reaction with full-length tau, or with tau truncated at Glu391 or Ala429 -
BD Pharmingen monoclonal
IgG1
Mouse
(aqueous buffered liquid, supernate, affinity purified, azide)
IH, WB Rat immunogen = phosphorylation -independent region in the middle of Tau recognizes both phos. and non phos. forms of Tau -
Biosource Invitrogen kit
Unknown Host
(contains:Hu Tau [pT181]Antibody Bead Concentrate;Hu Tau [pT181]Detection Ab Concentrate;Hu Tau [pT181] Standard)
ELISA Human human tau-derived peptide that is phosphorylated at threonine 181 for the measurement of human Tau when phosphorylated at threonine 181 in CSF and tissueculture media -
Pierce Thermo Scientific monoclonal
IgG1κ
Mouse
(frozen liquid, no carrier or preservative, biotin conj.)
ELISA, IH Bovine, Human immunogen = human tau, epitope between aa 159 and 163 tau and PHF tau tau between aa 159-163 -
Chemicon and Upstate are Millipore monoclonal
IgG2a
Mouse
(purified Ig, phosphate buffered, lyophilized)
IH, WB Bovine, Human, Rat immunogen = purified denaturated bovine MAPs (epitope at or near a phosphorylated site) binds to all known electrophoretic species of tau in human, rat and bovine brain (one-dimensional SDS-PAGE); there is some unphosphorylated bias with clone PC1C6 as it seem to recognize only dephosphorylated serine sites at 195, 198, 199, and 202 -
Abcam monoclonal
IgG1
Mouse
(liquid, IgG fraction, PBS, azide.For BSA and azide free, see ab80579)
IH, WB Human immunogen = purified bovine microtubule associated proteins specific to 45-68 kDa proteins identified as tau proteins; no cross with tubulin or other MAPs; phospho. as well as non-phospho. forms of tau -
Biosource Invitrogen polyclonal
Rabbit
(purified Ig, PBS, BSA, azide, glycerol, unconjugated)
IH, WB Human human tau-derived peptide that is phosphorylated at threonine 205 tau phosphorylated at threonine 205 -
Biosource Invitrogen polyclonal
Rabbit
(purified Ig, PBS, BSA, azide, glycerol, unconjugated)
WB Human human tau-derived peptide that is phosphorylated at serine 422 tau phosphorylated at serine 422 -
Pierce Thermo Scientific monoclonal
IgG1κ
Mouse
(supernatant, affinity purified, no carrier or preservativeAlso available biotin conj., MN-1050B)
IH, WB Human immunogen == partially purified human PHF tau, aa. around phosphorylated Thr181 PHF tau, tamgles and neurofilaments; no cross with recomb. unphospho tau; weak cross with normal tau -
Dako polyclonal
Ig
Rabbit
(serum, purified Ig fraction, azide)
IC, IH, IP, WB Human, Mouse, Rat immunogen = C-terminal part of human tau protein expressed in E. coli; aa. 243-441, contains the four repeated sequences involved in microtubule binding (MTB) reacts with tau protein and with tau from Alzheimer paired helical filaments; also MAP2; well-suited for gel immunoprecipitation techniques -
Biosource Invitrogen polyclonal
Rabbit
(affinity purified Ig, Dulbecco's PBS, BSA, glycerol, unconjugated)
WB Human phospho peptide derived from the region of human Tau that contains serine 214 detects tau phosphorylated at serine 204; no cross with non phosphorylated tau -
Pierce Thermo Scientific monoclonal
IgG1κ
Mouse
(purified, no carrier or preservative)
ELISA, IH, WB Human immunogen = aa. around phosphorylated Thr231 detects Tau doubly phosphorylated at Thr231 and Ser235; weak recognition of phosphorylation at Thr231 only -
Biosource Invitrogen monoclonal
IgG1
Mouse
(ascites, affinity purified BSA, azide, unconj.)
ELISA, IH, IP, WB Cow, Sheep, Human, Mouse, Rat immunogen = purified bovine microtuble associated proteins; epitope in middle region of tau tau proteins ranging from 45-68 kDa, not other MAPs or tubulin; tangles marker; reacts with non-phosphor. and phosphor. tau -
Autogen Bioclear kit
Mouse
(solid-phase enzymeimmunoassay, uses monoclonal AT120 for capture, HT7 and BT2 for incubation, streptavidin)
ELISA Human - tau in cerebrospinal fluid -
Innogenetics monoclonal
Mouse
ELISA, IH, WB Bovine, Human immunogen = purified human tau; (epitope within aa 159-163) phosphorylated and non phosphorylated tau -
Innogenetics monoclonal
IgG1κ
Mouse
(liquid, sterile filtered, PBS, no preservative, affinity purified)
ELISA, IH, WB Human immunogen = human tau40, aa. around phospho. Thr 181 specific for tau phospho at Thr 181; as PHF-tau, tangles and neurofilaments; weak cross with normal tau; -
Innogenetics kit
Mouse
(solid-phase enzymeimmunoassay, uses monoclonal AT120 for capture, HT7 and BT2 for incubation. Streptavidin detection of the antibodies.)
ELISA Human - tau in cerebrospinal fluid -
Synaptic Systems
Cat# 314011
monoclonal
IgG2a

(Purified IgG, lyophilized. Azide was added before lyophilization. Unconjugated.)
IC, IH, IP, WB Human, Mouse, Rat Recombinant mouse tau (amino acids 3 - 214) The antibody binds phosphorylated and non-phosphorylated tau proteins. Confirmed available March 2014
Synaptic Systems
Cat# 314 002
polyclonal
Rabbit
(antiserum, lyophilized. )
IC, IH, IP, WB Human, Mouse, Rat Recombinant mouse tau (amino acids 3 - 214). The antibody binds phosphorylated and non-phosphorylated tau proteins. Confirmed available March 2014
Pierce Thermo Scientific
Cat#  MN-1020
monoclonal
IgG1κ
Mouse
(Protein A affinity purified, PBS, no preservative)
Block, ELISA, IC, IF, IH, IP, WB Baboon, Human, Rabbit, Hamster, Avian (various), Drosophila immunogen = partially purified human paired helical filament tau. Recognizes tau protein phosphorylated at both serine 202 (Ser202) and threonine 205 (Thr205). Does not cross-react with unphosphorylated forms of tau.   Confirmed available April 2015.
Santa Cruz
Cat# sc-32275
monoclonal
IgG2b
Mouse
(liquid, PBS, azide, gelatin)
IF, WB Human immunogen = highly purified preparation of human paired helical filaments. Ser 396 phosphorylated tau -
BioLegend monoclonal
IgG1
Mouse
(high titer, ascites)
IH, WB Bovine, Rat (aa 95 to 108 sequence of tau in a conformation partially dependent on serine in position 101) strongly with PHF Tau in Alzheimer disease; weakly with normal tau Discontinued
BioLegend monoclonal
IgG1
Mouse
(liquid, ascites)
ELISA, IH, IP, WB Human (epitope maps to amino acid residues 2-18 on the longest isoform of human tau) binds to human tau and is able to stain brain tissue early in Alzheimer’s disease. TAU-13 is specific for human tau; it does not react with bovine, murine or rat tau Available from BioLegend
Autogen Bioclear monoclonal
IgG1
Mouse
(liquid, sterile filtered, PBS, no preservative)
ELISA, IH, WB Human immunogen = human PHF tau, aa. around phosphorylated Thr 212 and Ser 214 tau phospho. at Thr 212 and Ser 214; no cross with normal tau -
- monoclonal
IgG1
Mouse
(liquid, sterile filtered, PBS, no preservative)
ELISA, IH, WB Human immunogen = human PHF tau, aa. around phosphorylated Thr 212 and Ser 214 tau phospho. at Thr 212 and Ser 214; no cross with normal tau -
Autogen Bioclear monoclonal
IgG1
Mouse
(liquid, sterile filtered, PBS, no preservative, biotin)
ELISA, IH, WB Human immunogen = human PHF tau, aa. around phosphorylated Thr 212 and Ser 214 tau phospho. at Thr 212 and Ser 214; no cross with normal tau -
Pierce Thermo Scientific monoclonal
IgG1κ
Mouse
(biotin, no carrier or preservative)
ELISA, IH Human around phosphorylated Thr212 and Ser214 PHF tau with phosphorylated Thr212 and Ser214, not normal tau, or biopsy, autopsy or fetal tau. -
Pierce Thermo Scientific monoclonal
IgG1κ
Mouse
(purified, no carrier or preservative)
ELISA, IH, WB Human immunogen = tau around phosphorylated Thr212 and Ser214 PHF tau with phosphorylated Thr212 and Ser214, not normal tau, or biopsy, autopsy or fetal tau. -
None monoclonal
IgG1
Mouse
(liquid, semipurified Ig, serum-free , DMEM, thimerosal)
IF, IH, WB Human immunogen = Alzheimer tau isolated from AD brain (minimal epitope aa 321-391) recognizes Alzheimer tau, shows no cross-reactivity with MAPs or tubulin. Does not react with tau from age- matched control brains or with six recomb. tau isoforms -
- monoclonal
IgG1κ
Mouse
(liquid, PBS, sterile filtered, affinity purified)
ELISA, IH, WB Human partially purified human tau, aa. around phosphorylated Serine 202 Recognizes phosphorylated paired helical filament tau. Recognises tau protein phosphorylated at both serine 202 and threonine 205. No cross-reactivity with unphoshorylated tau. -
Pierce Thermo Scientific monoclonal
IgG1κ
Mouse
(serum-free supernatant, affinity purified, no carrier or preservative. Also available Biotin conj, MN-1000B)
ELISA, IH, WB Bovine, Human immunogen = purified human tau, between aa 159 and 163, (PPGQK) tau and PHF tau from human and bovine brain -