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Antibodies

778 Results

Name Source Clonality &
Isotype
Host &
Formulation
Method Reactivity Immunogen/
Epitope
Specificity Availability
APP, APLP, AICD From labs (15)
anti-APP C15(Dr. Kei Maruyama, Saitama Medical University, Saitama, Japan).PaperReference: Kitazume, 2010 polyclonal
Rabbit
IC, IH, IP, WB Human imunogen = residues 681-695 of APP recognizes C-terminal region of APP -
(Konrad Beyreuther, Center of Molecular Biology, University of Heidelberg, Heidelberg, Germany)PaperReference: Kuhn, 2010 monoclonal
Mouse
IH, WB Human, Monkey, Mouse, Rat immunogen = a bacterial APP fusion protein (Fd-APP 695), (epitope in ectodomain, at residues 66-81 of APP) detects a variety of mature as well as immature APP species which differ in their degree of glycosylation -
(Stefan Lichtenthaler, Adolf Butenandt Institute, Ludwig Maximilians University, München, Germany)PaperReference: Kuhn, 2010 monoclonal
IgG2a
Unknown Host
WB Human, Mouse immunogen = a peptide comprising amino acids 10–15 of the Aβsequence (YEVHHQ-COOH) specifically detects APPsα; detects also murine APPsα, but notAPPsβ and APPsβ' -
(Stefan Lichtenthaler, Adolf Butenandt Institute, Ludwig Maximilians University, München, Germany)PaperReference: Kuhn, 2010 monoclonal
IgG2a
Rat
WB Human immunogen = a peptide comprising amino acids 11–16 of the Aβsequence (EVHHQK-COOH) specifically detects APPsα ending in amino acids 15 and 16 (APPs-15 and APPs-16), but does not detect shorter APPs species, including APPsβ' and APPsβ; does not detect full-length APP -
(Stefan Lichtenthaler, Adolf Butenandt Institute, Ludwig Maximilians University, München, Germany)Paper, Ulrich et al.Reference: Kuhn, 2010 monoclonal
IgG2a
Rat
IP, WB Human immunogen = the peptide ISEVKM derived from the amino acids directly preceding the APPβ-secretase cleavage site detects APPsβ at the β cleavage site -
6687Christian Haass, Ludwig-Maximilians-Universität München, Munich, GermanyPaper, Steiner et al.Reference: Kojro, 2006 polyclonal
Unknown Host
- Human immunogen = the 20 most C-terminal amino acids of human APP human APP C-terminal -
APP B5 (5313)(Christian Haass, Ludwig-Maximilians-Universität München, Munich, GermanyPaper, Steiner et al.References:Kuhn, 2010Stamer, 2002 polyclonal
Unknown Host
IP Human immunogen = a sequence in the ectodomain, aa 444-592, of human APP reactive with APPs, ectodomain -
CT15(S Soriano, 2001Paper, JBC online,Dr. Edward Koo, University of California, San Diego),References:Lee, S, 2010Banwait, 2008Rockenstein, 2007Galvan, 2006 polyclonal
Rabbit
IP, WB Human, Mouse immunogen = syntheticpeptide corresp. to the C-terminal 15 residues of APP (aa 680-695) APP C-terminal fragments; recognizes the last 15 COOH-terminal amino acid residues of APP695 -
C1/6.1(Paul Mathews, New York University, School of Medicine,Center for Dementia Research)Research paperReferences:Pavlov PF, 2010Jiang Y., 2010Loane, 2009Hoe, 2009 monoclonal
IgG1
Mouse
(ascites)
IP, WB Human, Mouse immunogen = synthetic peptide, first 20 amino acids of the C-terminal, cytoplasmic domain of APP (residues 676–695 of APP695) recognizes full length APP and APP CTFs -
anti-APP 369(Sam Gandy,Mount Sinai Alzheimer's Disease Research Center, NYC)References:Lane RF, 2010Vieira SI, 2010Pavlov PF, 2010Li H, 2010Gandy, 2010Zhang, 2009Liu, Y, 2009Hoe, 2009Tampellini, 2007White, 2006Puglielli, 2001Li, 2003 polyclonal
Rabbit
IH, IP Human, Mouse immunogen = entire cytoplasmic tail of APP(paper) C-terminal APP -
anti-APP C7(Dr. Dennis Selkoe,Harvard Univ. Medical School, Boston, MA)Reference: Puglielli, 2001,by Yu, 2001 polyclonal
Rabbit
IH - last 20 residues of APP   -
anti-APP C9(Dr. Dennis Selkoe,Harvard Univ. Medical School, Boston, MA)References:Muresan, 2009Sato, 2007 polyclonal
Rabbit
IP, WB - synthetic peptide corresp. to APP732-751, (APP751 numbering)   -
anti-APP α-1(Dr. Dennis Selkoe,Harvard Univ. Medical School, Boston, MA polyclonal
Rabbit
IH, WB Human synthetic peptide of residues 649-664 APP -
R1736(Dr. Dennis Selkoe,Harvard Univ. Medical School, Boston, MA)Reference: Maier, 2008, polyclonal
Rabbit
(antiserum)
IP, WB Rodent (various), Human immunogen = synthetic peptide of amino acids 595–611 of APP APP epitope corresponds to positions -2 to +15 of human Abeta, and it presents 90%(15 out of 17 amino acids) of sequence homology with the hamster sequence which is identical to other rodents such as mouse -
anti-APP C8(Dr. Dennis Selkoe,Harvard Univ. Medical School, Boston, MA)References: Davis, 2010Senechal, 2008Wang, 2007 polyclonal
Rabbit
DB, IC, IH, WB Mammal (various), Human residues 676-695, comprising the 20 C-terminal amino acids of human βAPP cytoplasmic domain.Paper, Selkoe et al. recognizes full length APP and all CTFs -
APP, APLP, AICD From manufacturers (62)
ProSci polyclonal
IgG
Rabbit
(liquid, KPBS, azide, affinity purified)
ELISA, IF, IH, IP, WB Human immunogen = aa1-14 of human APP APP -
ProSci polyclonal
IgG
Rabbit
(liquid, PBS, affinity purified, azide, pos. control [#1463], blocking peptide [#5143P])
ELISA, IH, WB Human, Mouse, Rat immunogen = 18 aa peptide near the N-terminus of human APP APP -
ProSci polyclonal
Chicken
(lyophilized, PBS, sucrose, azide, affinity purified)
WB Human immunogen = APP extra protein from chromosome 21, 120KD APP extra protein from ch 21 (120kDa) -
ProSci polyclonal
IgG
Rabbit
(lyophilized, PBS, sucrose, azide, affinity purified)
ELISA, WB Human, Mouse, Rat immunogen = synthetic peptide corresp. a region of human APP APP -
ProSci monoclonal
IgG2a
Mouse
(liquid, ascites, azide protein A purified available)
IH, WB Human immunogen = Ni-NTA purified truncated recombinant APP expressed in E coli strain BL21 (DE3) APP -
ProSci polyclonal
IgG
Rabbit
(lyophilized, PBS, sucrose, affinity purified)
ELISA, WB Human, Mouse, Rat immunogen = synthetic peptide corresp. to a region of human APPBP2 APPBP2 -
QED Bioscience polyclonal
IgG
Rabbit
(liquid, serum, PBS, affinity purified, azide)
WB Human, Mouse, Rat immunogen = synthetic peptide, aa. 653-662 of APP A4, or 1 to 10 of the 4K Aβ peptide generated by β- and γ-secretases APP and Aβ peptide -
QED Bioscience polyclonal
IgG
Rabbit
(serum, PBS, affinity purified, azide)
WB Human, Mouse, Rat immunogen = synthetic peptide, aa. 737-751 of APP A4, or 85-99 of the C99 fragment generated by β-secretase APP and the C99 fragment -
R&D Systems kit
Unknown Host
(capture antibody = monoclonal anti-human phospho-APP; detection antibody = biotinylated anti-human phospho-APP T668)
ELISA Human, Mouse, Rat - quantitate APP phosphorylated at site corresp. T668 of the APP695 isoform -
RDI /Fitzgerald monoclonal
IgM
Mouse
(lyophilized, supernatant, azide)
- - immunogen = prokaryotic rh fusion protein corresp. to the extracellular portion of APP between Kunitz protease inhibitor domain and the β-amyloid region APP -
RDI /Fitzgerald polyclonal
Goat
(liquid, whole antiserum, no preservative)
ELISA, IH, WB Human immunogen = synthetic peptide ( H M NV Q N G K W D D D P S G T K TC I) corresp. to aa 339-348 on the C-terminus of human APP Frameshift Mutant (APPFM) specific for the C-terminus residues 339-348 on the mid-portion of APP FM -
RDI /Fitzgerald polyclonal
Goat
(liquid, neat serum, azide)
ELISA, IH Human immunogen = synthetic peptide (H M N V Q N G K W D D D P S G T K T C I ) corresp. to aa 44-63 of the N-terminus of the human APP aa seq. 44-63 on the N-terminus of APP -
RDI /Fitzgerald polyclonal
Goat
(neat serum, no preservative)
ELISA, IH Human, Monkey, Gerbil, Hamster, Mouse, Rat immunogen = synthetic peptide (H M N V Q N G K W D D D P S G T K T C I) corresp. to aa 44-63 on the N-terminus of APP specific for N-terminus aa44-63 of APP -
RDI /Fitzgerald polyclonal
Goat
(whole antiserum, no preservative)
ELISA, WB Human immunogen = synthetic Peptide: 681-695 G Y E N P T Y K F F E Q M Q N of the C-terminal of human APP aa seq. 681-695 of C-terminus of APP -
Santa Cruz polyclonal
IgG
Rabbit
(liquid, affinity purified, PBS, gelatin, azide)
ELISA, IF, IH, IP, WB Human immunogen = peptide mapping near the C-terminus of human APPBP1 APPBP1 -
Santa Cruz polyclonal
IgG
Goat
(liquid, affinity purified, PBS, gelatin, azide)
ELISA, IF, WB Human, Mouse, Rat immunogen = peptide mapping within in internal region of human APPBP1 APPBP1 -
Santa Cruz polyclonal
IgG
Goat
(liquid, affinity purified, PBS, gelatin, azide)
ELISA, IF, WB Human, Mouse, Rat immunogen = peptide mapping within in internal region of human APPBP1 APPBP1 -
Santa Cruz monoclonal
IgG2a
Mouse
(liquid, PBS, gelatin, azide)
ELISA, IP, WB Human immunogen = recombinant APPBP1 of human origin APPBP1 -
Santa Cruz monoclonal
IgG2a
Mouse
(liquid, PBS, gelatin, azide)
IP, WB Mammal (various), Dog, Human, Mouse, Rat immunogen = aa348-464 of human APPBP1 APPBP1 -
Santa Cruz polyclonal
IgG
Rabbit
(liquid, affinity purified, PBS, gelatin, azide)
ELISA, IP, WB Human immunogen = peptide mapping within an internal region of human APPBP2 APPBP2 -
Santa Cruz polyclonal
IgG
Goat
(liquid, affinity purified, PBS, gelatin, azide)
ELISA, IF, WB Human, Mouse, Rat immunogen = peptide mapping within an internal region of human APPBP2 APPBP2 -
Santa Cruz polyclonal
IgG
Rabbit
(liquid, PBS, gelatin, azide, affinity purified)
ELISA, IP, WB Human, Mouse, Rat immunogen = synthetic peptide of human APPBP2 APPBP2 -
Santa Cruz polyclonal
IgG
Goat
(liquid, affinity purified, PBS, gelatin, azide)
ELISA, IF, WB Human, Mouse, Rat immunogen = peptide mapping within an internal region of human APPBP2 APPBP2 -
Santa Cruz polyclonal
IgG
Goat
(liquid, affinity purified, PBS, gelatin, azide)
ELISA, IF, WB Human, Mouse, Rat immunogen = peptide mapping near the C-terminus of human APPBP2 APPBP2 -
Santa Cruz monoclonal
IgG2a
Mouse
(liquid, PBS, gelatin, azide)
ELISA, IP, WB Human immunogen = recombinant human APPBP2 APPBP2 -
Stressgen Enzo Life Sciences monoclonal
IgG1
Mouse
(lyophilized, PBS, sucrose, azide, protein A purified)
IH, WB Human, Mouse immunogen = 21 residue synthetic peptide (L E V P T D G N A G L L A E P Q I A M F C), aa 18-38, of human APP695 APP (~102kDa) -
Stressgen Enzo Life Sciences polyclonal
IgG
Rabbit
(PBS, azide, affinity purified)
WB Human, Mouse, Rat immunogen = human APP synthetic peptide (756-770) identical to human C99 fragment (aa 85-99) generated by βsecretase cleavage ~105 kDa protein doublet, corresp. to mass of APP isoforms; an additonal band of 35kDa corresp. to C99 fragment -
Synaptic Systems
Cat# 127 003
polyclonal
Rabbit
( lyophilized. Affinity purified with the immunogen. )
IC, IH, WB Human, Mouse, Rat, Chicken, Frog Synthetic peptide GYENPTYKFFEQMQN corresponding to the C-terminus of APP coupled to key-hole limpet hemocyanin via an added N-terminal cysteine residue. Specific for APP Confirmed available March 2014
Upstate and Chemicon are Millipore polyclonal
IgG
Rabbit
(frozen solution, PBS, azide, gelatin, protein G purified)
WB Human, Mouse, Rat immunogen = synthetic peptide corresp. to aa 672-681 (D A E F R H D S G Y) of the 770 aa isoform of human amyloid beta A4 protein precursor (APP) recognizes APP, 110kDa -
Upstate and Chemicon are Millipore monoclonal
IgG1
Mouse
(liquid, PBS, glycerol, azide, protein G purified)
WB Human, Rat immunogen = purified recombinant KPI domain of APP expressed in P. pastoris APP, KPI (Kunitz protease inhibitor) present in APP751 and APP770 but not in APP695 -
Upstate and Chemicon are Millipore polyclonal
Rabbit
(liquid, whole serum, azide, glycerol)
IC, IP, RIA, WB Human immunogen = synthetic peptide (Y-N V P G H E R M G R G R T S S K E L A) corresp. to aa 330-348 of human β-APP+1 APP+1 -
Zymed/ Invitrogen monoclonal
IgG1κ
Mouse
(liquid, purified, PBS, azide)
ELISA, IB, IH, WB Human Immunogen = recombinant-β-APP695; epitope = first 200 aa in N-terminus all three forms of β-APP (APP695, 751, 770) -
Zymed/ Invitrogen monoclonal
IgG1
Mouse
(liquid, affinity purified Ig, PBS; carrier and preservative free)
ELISA, IC, IP, WB Human, Monkey Immunogen = full length native secreted form of amyloid precursor protein, APP751. (epitope within a.a. 104-118) specific for native, not denatured, conformations of APP -
Zymed/ Invitrogen polyclonal
Rabbit
(liquid, purified, PBS, BSA, glycerol)
WB Human immunogen = a chemically synthesized phosphopeptide derived from the region of human APP that contains threonine 668, corresp. to the APP695 isoform detects APP phospho. at threonine 668 -
Chemicon and Upstate are Millipore polyclonal
Rabbit
(liquid, serum, PBS, azide)
IC, IH, IP, WB Bovine, Human, Monkey, Mouse immunogen = synthetic peptide APP aa 99-126, KPI domain APP specific to aa 99-126 -
Chemicon and Upstate are Millipore polyclonal
Rabbit
(liquid, serum, azide)
IC, IH, IP, WB Human, Monkey immunogen = synthetic peptide corresponds to OX2 domain of APP770 Amyloid Precursor Protein (APP) 770, epitope in OX2 domain -
Chemicon and Upstate are Millipore polyclonal
Rabbit
(liquid, tris-buffered saline, azide, affinity purified)
IC, IH, IP, WB Human, Monkey immunogen = synthetic peptide corresponds to OX2 domain of APP770 Amyloid Precursor Protein (APP) 770, epitope in OX2 domain -
IBL polyclonal
IgG
Rabbit
(lyophilized, BSA, PBS, azide, purified)
IP, WB Human immunogen = synthetic peptide in portion of C-terminus of human sAPPβ-wild type(I S E V K M) detects sAPP-Wild type which is clevaged by β-secretase; no cross with sAPPα or full-length APP -
Sigma Aldrich polyclonal
IgG
Rabbit
(IgG frac, PBS, azide)
IB, IH Human, Mouse, Rat immunogen = synthetic, aa 46-60 of the N terminus of APP695 APP695, APP751 and APP770 -
Epitomics monoclonal
Mouse
(liquid, Tris-Glycine, NaCl, Glycerol, BSA, azide)
FC, IC, IH, IP, WB Human, Mouse, Rat immunogen = synthetic peptide corresponding to residues in the NPXY motif of human APP specifically recognizes APP and its isoforms; will not recognize either of the two Amyloid Beta Protein (Aβ4) variants, Aβ1 -40 or Aβ1 -42 -
Calbiochem EMD Biosciences polyclonal
IgG
Goat
(liquid, neat serum, no preservative)
ELISA, IH Human immunogen = synthetic peptide (Y E V H H Q K L V F F A E D V) corresp. to aa 44-63 of human APP APP (~110-135 kDa) -
Abcam monoclonal
IgG1
Mouse
(liquid, supernatant, azide)
IC, IH, IP, WB Cow, Pig, Human, Monkey immunogen = synthetic peptide corresp. to aa 1-17 of the mature human Amyloid Precursor Protein, conjugated to KLH. reacts with β-amyloid peptide and secreted APP (alpha-secretase cleaved); has very weak recognition of full length APP and we do not recommend it for this purpose; does however strongly recognize alpha-secretase cleaved soluble APP as well as b-amyloid peptide (40 and 42) -
Zymed/ Invitrogen polyclonal
Rabbit
(liquid, affinity purified, PBS, azide)
IH, IP, WB Human, Mouse immunogen = synthetic peptide derived from the C-terminal region of the human and mouse amyloid-β precursor protein (APP695) APP full length (~100kDa) and C99 C-terminal cleavage frag (~10-12kDa); cross-react with APLP2 -
Zymed/ Invitrogen polyclonal
Rabbit
(affinity purified, PBS, azide)
ELISA, IF, IH, WB Pig, Human, Mouse, Rat Immunogen = synthetic peptide of 22 aa from the C-terminus of human β-APP All three forms of full length APP and N-terminal truncated forms of β-APP. Detects C-terminal membrane fragment of β-APP that remains after α -or β-secretase cleavage -
Chemicon and Upstate are Millipore monoclonal
IgG1
Mouse
(liquid, PBS, azide, purified)
IF, IH, WB Fish (various), Dog, Pig, Human, Monkey, Mouse, Rat immunogen = purified rhN-terminal epitope (aa 66-81) on the pre-A4 molecule, fusion protein human pre-A4 APP; recognizes all three isoforms of APP, immature ~110kDa, sAPP ~120kDa, and mature ~130kDa; cross reacts with APLP2 -
Biosource Invitrogen polyclonal
Goat
(liquid, whole serum, azide, unconj.)
ELISA, WB Human immunogen = synthetic peptide (G Y E N P T Y K F F E Q M Q N) corresp. to aa sequence 681-695 of C terminus of human APP C-terminus of APP(100kDa), may cross-react with APLP2 -
Chemicon and Upstate are Millipore monoclonal
IgG1
Mouse
(liquid, PBS, azide, purified)
IF, IH, WB Fish (various), Dog, Pig, Human, Monkey, Mouse, Rat immunogen = purified rhN-terminal epitope (aa 66-81) on the pre-A4 molecule, fusion protein human pre-A4 APP; recognizes all three isoforms of APP, immature ~110kDa, sAPP ~120kDa, and mature ~130kDa; cross reacts with APLP2 -
Chemicon and Upstate are Millipore monoclonal
IgG1
Mouse
(lyophilized, ascites)
IH, WB Human, Rat immunogen = C-terminal fragment APP643-695/Jonas full-length APP and selectively with the cytoplasmic C-terminal fragment of APP 643-695 -
Synaptic Systems
Cat# 127 002
polyclonal
Rabbit
(antiserum, lyophilized. )
IC, IH, WB Human, Mouse, Rat, Chicken, Frog Synthetic peptide GYENPTYKFFEQMQN corresponding to the C-terminus of APP coupled to key-hole limpet hemocyanin via an added N-terminal cysteine residue. Specific for APP. Confirmed available March 2014
None monoclonal
IgG1
Mouse
(liquid, PBS, no preservative, purified)
ELISA, IF, IH, IP, WB Human immunogen = aa 1-17; epitope aa 4-9 of β-Amyloid peptide Amyloid beta protein, amino acid residues 1-17 Discontinued
BioLegend monoclonal
IgG1
Mouse
(Purified by affinity chromatography. PBS, no preservatives or carrier proteins.)
ELISA, IB, IC, IF, IH, IP, WB Human, Mouse epitope lies within amino acids 3-8 of beta amyloid (EFRHDS) reactive to aa 1-16 Aβ and to APP; reacts to the abnormally processed isoforms, as well as precursor forms Available from BioLegend
BioLegend monoclonal
IgG1
Mouse
(purified, PBS, no preservatives or carrier proteins)
ELISA, IH, WB Human, Mouse Epitope lies within amino acids 573-596 of amyloid precursor protein reactive to aa 17-24 Aβ and to APP Available from BioLegend
BioLegend polyclonal
Rabbit
(liquid, no preservatives, or carriers, affinity purified)
ELISA - - specific for AICD (APP intracellular domain), a peptide fragment that results from the cleavage of C83 or C99 at the epsilon site. No reaction with the C57 or C59 γ-secretase cleavage products of APP. Available from BioLegend
None polyclonal
Rabbit
(PBS, no preservatives, stabilizers or carriers, affinity purified)
ELISA, IB - - specific for the soluble fragment resulting from the α-secretase cleavage of APP. It has no cross reactivity to sAPPβ β-amyloid or full length APP Discontinued
BioLegend polyclonal
IgG
Rabbit
(PBS, no preservatives, stabilizers or carriers, affinity purified)
ELISA - - specific for the soluble fragment cleaved n-terminus to the β-secretase cleavage site of APP. It has negligible cross reactivity to sAPPα or full length APP Available from BioLegend
BioLegend monoclonal
IgG1
Mouse
(purified, ascites, PBS, no preservatives or carrier proteins)
ELISA, IH, WB Human Epitope lies within amino acids 61-77 of amyloid precursor protein APP Available from BioLegend
BioLegend monoclonal
IgG1
Mouse
(purified, PBS, no preservatives or carrier proteins, biotinylated)
ELISA, IH, WB Human Epitope lies within amino acids 573-596 of amyloid precursor protein APP Available from BioLegend
BioLegend monoclonal
IgG1
Mouse
(liquid, protein G purified, no preservative)
ELISA, IH, WB - - recognizes all three known forms of APP (amyloid precursor protein), β-APP695, β-APP751 and β-APP770 Available from BioLegend
BioLegend monoclonal
IgG2b
Mouse
(crude ascites)
ELISA, IH, IP, WB Human, Mouse epitope within amino acids 18-23 of the Aβ peptide reactive to amino acids 17-24 of Aβ and to APP Available from BioLegend
BioLegend monoclonal
IgG2b
Mouse
(purified PBS thimerosal no BSA)
ELISA, IH, IP, WB Human, Mouse amino acid residue 17-24 of beta Amyloid peptide reactive to aa 17-24 Aβ and to APP Available from BioLegend
None kit
IgG1
Rabbit
ELISA Human, Mouse, Rat immunogen = synthetic peptide corresp. to aa 573-596 of APP (amyloid precursor protein) specific for the β isoform of sAPP (soluble amyloid precursor protein). It has negligible cross reactivity with β amyloid 40, 42, or sAPPα Discontinued
BioLegend polyclonal
Rabbit
(affinity purified, PBS, no preservatives or carrier proteins)
ELISA - - reactive to C-terminal fragment of APP (APPc) Available from BioLegend
Amyloid-β, APP, APLP, AICD From manufacturers (1)
BioLegend monoclonal
IgG2b
Mouse
(biotinylated IgG, PBS, no preservatives or carrier proteins)
ELISA, IH, IP, WB Human, Mouse the epitope lies within amino acids 18-22 of beta amyloid (VFFAE) reactive to aa 17-24 Aβ and to APP -