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Antibodies

619 Results

Name Source Clonality &
Isotype
Host &
Formulation
Method Reactivity Immunogen/
Epitope
Specificity Availability
Amyloid-β From labs (27)
2964(Jochen Walter,Department of Neurology, University of Bonn, Bonn,Germany)PaperReference: Heneka, 2010 polyclonal
Rabbit
IP Human, Mouse immunogen = synthetic Aβ40 detects Aβ -
WO2(Brian O'Nuallain,Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, TN)PaperReference: Villemagne, 2010 monoclonal
IgM
Mouse
FA, WB Human, Mouse raised against sonicated amyloid fibrils grown from synthesized Aβ1–40 peptides (epitope at Aβ residues 5–8) detects amyloid-beta fibrils; exhibits Ab binding to fibrils in the presence of a large excess of Aβ(1–40) monomer, suggesting that Ab is directed against conformational epitopes that only exist in the fibril -
G2-11Konrad BeyreutherCenter for Molecular Biology Heidelberg (ZMBH), University of HeidelbergPaperReference: Villemagne, 2010 monoclonal
Mouse
(liquid, purified, PBS, BSAAlso see Chemicon MABN12)
FA, IH, WB Human, Mouse immunogen = synthetic peptide corresponding to Aβ42, aa. 35-42 (MVGGVVIA), conjugated with KLH or BSA through a cysteine residue added at the N terminus of the peptides recognizes Amyloid β42 at the C-terminus -
G2-10Konrad BeyreutherCenter for Molecular Biology Heidelberg (ZMBH), University of HeidelbergPaperReference: Villemagne, 2010 monoclonal
Mouse
(liquid, purified, PBS, BSAAlso see Chemicon MABN11)
FA, IH, WB Human, Mouse immunogen = synthetic peptide corresponding to Aβ40, aa. 33-40 (GLMVGGVV), conjugated with KLH or BSA through a cysteine residue added at the N terminus of the peptides recognizes Amyloid β40 at the C-terminus -
amyloid-beta R165(Pankaj Mehta,Department of Immunology, New York State Institute for Basic Research, Staten Island, New York)References: Chung, E, 2010Schupf, 2008Sigurdsson, 2001 polyclonal
Rabbit
(Sandwich ELISA)
ELISA -   amyloid-beta 42 -
amyloid-beta R162(Pankaj Mehta,Department of Immunology, New York State Institute for Basic Research, Staten Island, New York)References: Chung, E, 2010Schupf, 2008Sigurdsson, 2001 polyclonal
Unknown Host
(Sandwich ELISA)
ELISA -   amyloid-beta 40 -
anti-amyloid beta FCA3340(Frédéric Checler,Centre National de la Recherche Scientifique),PaperReference: Gandy, 2010 polyclonal
Rabbit
DB, ELISA, IP, WB Human, Mouse immunogen = synthetic octapeptide Cys-GLMVGGVV, mimicing the C-terminal end of Aβ 40, coupled to either BSA or KLH amyloid-beta 40; labels leptomeningeal and cortical arterioles;little or no cross with Aβ 42 -
FCA3542(Frédéric Checler,Centre National de la Recherche Scientifique),PaperReferences:Gandy, 2010Lesné, 2006 polyclonal
Rabbit
(serum)
DB, ELISA, IP, WB Human, Mouse immunogen = synthetic octapeptide Cys-MVGGVVIA, mimicing the C-terminal end of Aβ 42, coupled to either BSA or KLH recognizes amyloid-beta 42; little or no cross with Aβ 40; intensely labels both diffuse and mature lesions -
JRF/rAβ/2 (Paul Mathews, New York University, School of Medicine,Center for Dementia Research)Research paperReference: Boland, 2010 monoclonal
Mouse
(liquid, horseradish peroxidase conj.)
ELISA, WB Mouse immunogen = a peptide corresponding to murine Aβ residues 1–15 (DAEFGHDSGFEVRHQ) recognizes mouse but not human Aβ1–40 or Aβ1–42 -
JRF/Aβtot/17(Paul Mathews, New York University, School of Medicine,Marc Merken,Johnson & Johnson Pharm. R&D,paper)References:Gandy, 2010Trinchese, 2008Mi, 2007 monoclonal
Mouse
ELISA, IB Human immunogen = human Aβ1-40 amyloid-beta, binds within residues 1-15 -
JRF/rAβ1-15/2(Paul Mathews, New York University, School of Medicine,Marc Merken,Johnson & Johnson Pharm. R&D,paper)References:Gandy, 2010 monoclonal
Mouse
ELISA Mouse epitope within residues 1-15 of mouse Aβ binds to amyloid-beta -
JRF/cAβ40/10(Paul Mathews, New York University, School of Medicine,Marc Mercken,Johnson & Johnson Pharm. R&D,Paper)References:Boland, 2010Trinchese, 2008Mi, 2007Razmahel, 2002 monoclonal
Mouse
ELISA, WB Human, Mouse immunogen = a peptide corresponding to Aβ residues 36–40 (VGGVV) recognizes the carboxyl terminus of Aβ40; does not detect Aβ1–42 by ELISA or WB, or full-length APP by IP or WB -
JRF/cAβ42/26(Marc Mercken,Johnson & Johnson Pharm. R&D,Paper)References:Boland, 2010Trinchese, 2008Mi, 2007Razmahel, 2002 monoclonal
Mouse
ELISA Human, Mouse immunogen = the carboxy terminal 10 residues of Ab1-42 amyloid-beta 42, C-terminus -
(Konrad Beyreuther, Center of Molecular Biology, University of Heidelberg, Heidelberg, Germany)PaperReference: Kuhn, 2010 monoclonal
IgG2a
Mouse
ELISA, IH, WB Human, Guinea Pig immunogen = decapeptides overlapping each other by one aminoacid, covering residues 1-42 of Aβ (epitope mapping corr. to amino acid residues 4-10 of human Aβ-peptide) High affinity to Amyloid peptides Aβ 1-38, Aβ 1-39, Aβ 1-40 -
3552(Harald Steiner,Laboratory for Alzheimer’s and Parkinson’s Disease Research, Adolf ButenandtInstitute, Ludwig Maximilians University, Munich, Germany)PaperReference: Kuhn, 2010 polyclonal
Unknown Host
IP, WB Human immunogen = Aβ1–40 recognizes amyloid-beta -
OC(paper on antibodies;paper on oligimerization; Charles G Glabe, University of California, Irvine)References:Lefterov, 2010Clinton, 2010Blurton-Jones, 2009 polyclonal
Rabbit
(serum)
DB, ELISA, IH, WB Human immunogern = a morphologically homogeneous population of Aβ42 fibrils specifically recognizes fibrils, but not random coil monomer or prefibrillar oligomers; also recognizes 100,000 × G soluble fibrillar oligomers ranging in size from dimer to greater than 250 kDa on western blots. The fibrillar oligomers recognized by OC are immunologically distinct from prefibrillar oligomers recognized by A11, even though their sizes overlap broadly -
IC16(Claus U. Pietrzik,Institute of Physiological Chemistry and Pathobiochemistry, MolecularNeurodegeneration, Johannes-Gutenberg-University Mainz, Mainz, Germany)paper)Reference: Richter L, 2010 monoclonal
Mouse
ELISA, IB Human immunogen = synthetic human Ab peptide 1–16, cross-linked to keyhole limpet hemocyanin recognizes residues 1-16 of Amyloid β. Hybridoma cells were generated by standard procedures and screened for recognition of HSA cross-linked to Ab 1-16by ELISA; recognition of synthetic Ab 1–42 ona standardized dot blot procedure was confirmed and the epitope mapped to Ab 1–8 using a peptide array spanning the entire sequence of Ab -
BAP-17(Manfred Brockhaus, F. Hoffmann-La Roche Ltd., Basel,Paper) monoclonal
IgG1
Mouse
(purified from spent hybridoma medium and conjugated to horseradish peroxidase)
ELISA, FA Human immunogen = the peptide CMVGGVV conjugatedto keyhole limpet hemocyanin specific for Aβ40; no cross-reactivity observed with Ab39, Ab42 or Ab43. Ab41 showed a signal accounting for about10% of the cognate Ab40 signal -
BAP-15(Manfred Brockhaus, F. Hoffmann-La Roche Ltd., Basel,Paper)Reference: Richter L, 2010 monoclonal
Mouse
(purified from spent hybridoma medium and conjugated to horseradish peroxidase)
ELISA, FA Human immunogen = the peptide CGGVVIA conjugatedto keyhole limpet hemocyanin specific for Aβ42; no cross-reactivity observed with Ab39, Ab40 or Ab43. Ab41 showed a signal accounting for about10% of the cognate Ab42 signal -
BAN-50(N Suzuki,Takada Chemical Industries)References:Wang S, 2010Fukumoto, 2010Suzuki, 1994 monoclonal
Mouse
ELISA, WB Human, Mouse raised against Aβ 1-16 (epitope at aa 1-10) amyloid-beta -
1E8(Paul Cutler,SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex, UKpaper: Cutler, et al, l997) monoclonal
Mouse
ELISA, IB, IH, IP Bovine, Human immunogen = the derived peptide sequence aa. 13–22, (epitope at aa. 18-22, VFFAE) of beta amyloid reacts with the N terminal of amyloid-beta; recognizes Aβ[1–40], Aβ[1–42] and Aβ[1–43] -
anti-amyloid beta 21F12(Frederique Bard,Elan Pharmaceuticals, So. San Francisco, CA Paper: Johnson-Wood, et al, PNAS February 18, 1997)References:Siderowf, 2010Okereke, 2009Serneels, 2009Brody, 2008Holmes, 2008Shankar, 2008Roberson, 2007Salehi, 2006 monoclonal
Unknown Host
IH, WB - immunogen = synthetic peptide fragment derived from different regions of amyloid-beta and coupled to a carrier protein amyloid-beta; recognizes amino acids 33-42; negligible crossreactivity (1–40 -
- monoclonal
IgM,κ
Mouse
FA, WB Human, Mouse raised against sonicated amyloid fibrils grown from synthesized Aβ1–40 peptides (epitope within aa 1-16) detects amyloid-beta fibrils; exhibits binding to fibrils in the presence of a large excess of Aβ(1–40) monomer, suggesting it is directed against conformational epitopes that only exist in the fibril -
- monoclonal
IgG1
Rat
(supernatant)
ELISA, FACS, IC, IH, IP, WB Human This antibody was raised against the native human APP ectodomain (isoform 695, which lacks the KPI domain). The epitope is believed to lie between amino acids 40 and 64. Specific to human APP. Does not cross-react with mouse, rat, dog, or guinea pig. Contact Stefan Lichtenthaler
- monoclonal
IgG1
Rat
(supernatant)
ELISA, FACS, IC, IH, WB Human This antibody was raised against the native human APP ectodomain (isoform 695, which lacks the KPI domain). The epitope is believed to lie between amino acids 40 and 64. Specific to human APP. Does not cross-react with mouse, rat, dog, or guinea pig. Contact Stefan Lichtenthaler
Seubert, Elan Pharmaceuticals monoclonal
Mouse
ELISA Human, Mouse immunogen = synthetic peptide, central domain 13-28 of Aβ1-42 (epitope at 16-23) - -
Elan Pharmaceuticals monoclonal
Mouse
ELISA, IH, WB Human, Mouse immunogen = synthetic peptide fragment conjugated to sheep anti-mouse immunoglobulin; epitope at aa 1-5 within Aβ42 Aβ (recognizes amino acids 1-5). Does not recognize secreted APP or APP-FL. Detects only Aβ species with amino-terminal aspartic acid.   -
Amyloid-β From manufacturers (73)
Genetics Company, Inc. kit
Unknown Host
(Solid phase sandwich ELISA test, detection range of 25-500pg/ml, low sampla volumes)
ELISA Human, Guinea Pig, Mouse Monoclonal detection and capture antibodies selective determination ofhuman Amyloid b42 (hAb42) in brain samples and for other tissue samples.; reliable, quantitative determination of human Amyloid b42 peptides in brain homogenates. -
Genetics Company, Inc. kit
Unknown Host
(Solid phase sandwich ELISA test, detection range of 100-2000pg/ml)
ELISA Human Monoclonal detection and capture antibodies Aβ 40 in CSF; not Aβ 1-38, Aβ 1-39, Aβ 1-42, Aβ 1-43 or Aβ 1-44 -
Genetics Company, Inc. kit
Unknown Host
(Solid phase sandwich ELISA test, detection range of 100-2000pg/ml)
ELISA Human Monoclonal detection and capture antibodies Aβ 42 in CSF; not Aβ 1-38, Aβ 1-39, Aβ 1-40; low cross reactivity with Aβ 1-43 (13%), Aβ 1-44 (10%) -
Biosource Invitrogen polyclonal
Rabbit
(affinity purified serum, PBS, carrier and preservative free, unconj.)
DB, ELISA, IH, RIA Human, Mouse, Rat   specific to Amyloid β42; not Amyloid β40 or Amyloid β43 -
Chemicon and Upstate are Millipore polyclonal
Rabbit
(liquid, tris, BSA, azide, affinity purified)
ELISA, IH, WB Human, Mouse immunogen = a 6 aa peptide sequence from the C-terminal of human β-amyloid 1-42. β-amyloid 1-42 -
Wako Chemicals kit
Mouse
(96 tests:BNT77/BA27(Fab') HRP conj. antibodies from Takeda Chemical Industries.range: 1.0~100 pmol/L.)
ELISA Human, Mouse, Rat   detects C-terminal of Aβ 40 -
Wako Chemicals kit
Mouse
(96 tests: BNT77/BC05(Fab') HRP conj. antibodies from Takeda Chemical IndustriesDetection sensitivity of the kits isabout 10 times higher than that of the conventional products and the dynamic range is from 0.1 to 20.0 pmol/L. Fab' fragment of the labeled antibody is used as well so that the nonspecific binding is reduced)
ELISA Human, Mouse, Rat BNT77: Specifically detects the Aβ (11-28) of AβBC05: Specifically detects the C-terminal of Aβ 42 detects Aβ (1-42) and Aβ (x-42) -
Upstate and Chemicon are Millipore kit
Unknown Host
(AB1518SP anti-neurofibrillary tangles; MAB1561SP anti-amyloid, beta, juxtamembrane EC domain, clone 4G8; MAB5206SP anti-amyloid, beta 1-16, clone DE2)
- - 3 antibodies in package detects amyloid beta -
Chemicon and Upstate are Millipore monoclonal
IgG2b
Mouse
(liquid, purified, buffer, Tris-glycine, BSA, azide)
ELISA, IH, WB Human, Mouse immunogen = linear peptide of human Amyloid β40 at the C terminus recognizes Amyloid β40 at the C-terminus -
Stressgen Enzo Life Sciences monoclonal
IgG2b
Mouse
(PBS, glycerol, azide, protein A purified)
WB Human, Mouse immunogen = synthetic peptide derived from sequence near the amino-terminus of human Amyloid β Amyloid β (4-5kDa), N-terminal of β-Amyloid 40/42; no reaction with recombinant APP -
Stressgen Enzo Life Sciences monoclonal
IgG1
Mouse
(purified, PBS, azide, PEG, sucrose, lyophilized)
ELISA, IC, WB Human immunogen = C-terminal peptide conjugated to KLH; C-Terminus of Amyloid beta-A4 (1-40) reactive to C-terminus of Amyloid β 1-40; does not cross-react with Amyloid β (1-42) -
Stressgen Enzo Life Sciences monoclonal
IgG1
Mouse
(purified, PBS, azide, PEG, sucrose, lyophilized)
ELISA, IC, WB Human immunogen = C-terminal peptide conjugated to KLH; C-Terminus of Amyloid beta-A4 (1-42) reactive to C-terminus of Amyloid β 1-42; no cross-reaction with Amyloid β (1-40) -
Stressgen Enzo Life Sciences monoclonal
IgG1
Mouse
(lyophilized, purified, PBS, azide, PEG, sucrose)
ELISA, IC, WB Human immunogen = C-terminal peptide conjugated to KLH; C-Terminus of Amyloid beta-A4 (1-40, 1-42) Amyloid β 40/42; cross reacts with APP -
Stressgen Enzo Life Sciences monoclonal
IgG2a, κ
Mouse
(liquid, PBS, azide, protein A/G affinity purified)
ELISA Human immunogen = human amyloid beta-peptide aa 5-16, R H D S G Y E V H H Q K, coupled to carrier Amyloid β (5-16) -
Stressgen Enzo Life Sciences monoclonal
IgG2a, κ
Mouse
(liquid, PBS, azide, protein A/G affinity purified)
ELISA Human immunogen = human amyloid beta-peptide aa 5-16, R H D S G Y E V H H Q K, coupled to carrier recognizes Amyloid β -
Stressgen Enzo Life Sciences monoclonal
IgG2a, κ
Mouse
(liquid, PBS, azide, protein A/G affinity purified)
ELISA Human immunogen = human amyloid beta-peptide aa 5-16, R H D S G Y E V H H Q K, coupled to carrier Amyloid β -
Stressgen Enzo Life Sciences monoclonal
IgG1, κ
Mouse
(liquid, PBS, azide, protein A/G affinity purified)
ELISA Human immunogen = synthetic human amyloid beta-peptide aa 5-16, R H D S G Y E V H H Q K, coupled to carrier amyloid beta -
Genetics Company, Inc. monoclonal
IgG2b
Mouse
(affinity purified IgG, PBS, azide)
ELISA, IH, WB Dog, Human, Guinea Pig, Mouse, Rat, Cynomolgus C-terminal epitope mapping corr. to amino acid residue 31-40 of human Aβ peptide recognizes Aβ-peptide, aa 31-40; selective for C-terminal of Aβ- 1-40; not Aβ 1-38, Aβ 1-39, Aβ 1-42, Aβ 1-43 or Aβ 1-44 -
Biosource Invitrogen kit
Unknown Host
(solid phase sandwich ELISA, capture and (same) detection antibody, SAV-HRP, colorimetric.sensitivity of this assay is )
ELISA Human - Recognizes aggregated Aβ in homogenates, ventricular fluid, CSF, tissue culture supernatant, and buffered solution samples -
Biosource Invitrogen polyclonal
Ig
Rabbit
(liquid, affinity purified, PBS, azide)
DB, ELISA, IH, Neut Human immunogen = synthetic molecular mimic of soluble oligomers A11 recognizes amino acid sequence independent oligomers of proteins and peptides, including Aβ40 and Aβ42; not monomers or mature fibers of proteins or peptides -
Acanthus Research polyclonal
IgG1
Rabbit
(liquid, serum)
ELISA, IH, WB Human, Mouse immunogen = synthetic peptide corresp. to 1-8 amino acid residuesfrom N-terminus of human Amyloid Betaprotein, conjigated with a carrier protein reactive to the N-terminal region (a.a. residues 1-8) ofAmyloid Beta peptide -
Acanthus Research monoclonal
IgG1
Mouse
(liquid, ascites, azide free)
ELISA, IF, IH, WB Human, Mouse, Rat immunogen = (3-8) N-terminal pyroglutamated synthetic amyloid beta peptide conjigated with a carrier protein reactive to N-terminal truncated Ab starting with pyroglutamate (pGlu, pE) -
IBL kit
Unknown Host
(solid phase sandwich ELISA using 2 kinds of high specific antibodies, range of 12.5 pg/ml ~ 800 pg/ml. Precoated plate with Aβ(38-42) Rabbit IgG; labeled antibody Anti-Human Aβ(11-28) Mouse IgG)
ELISA Human - quantitative determination of human A β (1-42) in cerebrospinal fluid, cellculture media or the extract from brain tissue, both recombinant and native forms of human Aβ(1-42) -
IBL kit
Unknown Host
(solid phase sandwich ELISA, using 2 kinds of highly specific antibodies; range of 7.8 pg/ml ~ 500 pg/ml. Precoated plate with monoclonal 1A10, and labeled antibody 12B2)
ELISA Human - quantitative determination of human Aβ(1-40) in EDTA-plasma, cerebrospinal fluids, serum, cell culture media or the extract from brain tissue; both recombinant and native forms of human Aβ(1-40), and little cross with (1-42) or (1-43) -
Wako Chemicals kit
Mouse
(96 tests:BNT77/BA27(Fab')2, HRP conj. antibodies from Takeda Chemical Industries.range: 1.0~100 pmol/L.Achieved stable antigen-antibody reaction)
ELISA Human, Mouse, Rat achieves more stable antigen-antibody reactions by using F(ab' )2 fragment of the labeled antibody BA27, which recognizes the C-terminal of beta Amyloid 40, while the nonspecific binding is remaining to be reduced detects the C-terminal of Aβ (1-40) and Aβ (x-40) -
Wako Chemicals kit
Mouse
(96 tests: BNT77/BC05(Fab') HRP conj. antibodies from Takeda Chemical Industries. range: 1.0~100 pmol/L)
ELISA Human, Mouse, Rat BNT77: Specifically detects the Aβ (11-28) of AβBC05: Specifically detects the C-terminal of Aβ 42 detects Aβ (1-42) and Aβ (x-42) -
Innogenetics kit
Mouse
ELISA Human Uses 21F12 as a capture antibody and incubation with biotinylated 3D6; 3D6 selectively binds Aß peptides with a free aminogroup at Asp1 (epitope 1–5) amyloid beta (cerebrospinal fluid) -
Biosource Invitrogen monoclonal
IgG
Rabbit
(liquid, PBS, azide)
ELISA, IH Human, Mouse immunogen = peptide (VGGVVIA) corresp. to aa707-713 of P05067 specific to Amyloid β1-42; not Amyloid β1-40, Amyloid β1-43, Amyloid β1-37 or Amyloid β1-38 -
Biosource Invitrogen monoclonal
IgG
Rabbit
(liquid, PBS, azide, protein A purified)
ELISA, IH Human immunogen = aa residues from the C-terminus of human amyloid beta A4 protein specific to Amyloid β42; no cross reaction with Amyloid beta 1-40 -
- monoclonal

(supernat, RIA screened, HPLC purified)
IH, WB - immunogen = synthetic peptide fragment derived from different regions of amyloid-beta and coupled to a carrier protein amyloid-beta -
Genetics Company, Inc. monoclonal
IgG2b
Mouse
(liquid, supernatant, stabilizing solution, affinity purified, conj. HRP)
ELISA, WB Dog, Human, Guinea Pig, Mouse, Rat, Cynomolgus C-terminal epitope mapping corr. to amino acid residues 31-40 of human Aβ peptide recognizes Aβ-peptide, aa 31-40; selective for C-terminal of Aβ 1-40; not Aβ 1-38, Aβ 1-39, Aβ 1-42, Aβ 1-43 or Aβ 1-44 -
Genetics Company, Inc. monoclonal
IgG1
Mouse
(liquid, stabilizing solution, no azide, affinity purified, conj. HRP)
ELISA, IH, WB Dog, Human, Guinea Pig, Mouse, Rat, Cynomolgus immunogen = Aβ 1-42 peptide at the C-terminus C-terminal of Aβ 1-42 peptide; not Aβ 1-38, Aβ 1-39, Aβ 1-40; low cross reactivity to Aβ 43 (10%)and Aβ 44 (13%) -
Genetics Company, Inc. monoclonal
IgG2a
Mouse
(supernatant IgG, Tris, azide, affinity purifiedAlso available Biotin or peroxidase conjugated)
ELISA, WB Human N-terminal: Epitope mapping corr. to amino acid residues 4-10 of human Aβ-peptide High affinity to the N-terminal of human Amyloid β peptides Aβ 1-38, Aβ 1-39, Aβ 1-40, Aβ 1-43 and Aβ 1-44 -
Cell Signaling polyclonal
Rabbit
(liquid, HEPES, NaCl, BSA, glycerol, affinity purified)
IF, IH, WB Bovine, Human, Rat immunogen = synthetic peptide corresp. to residues at the N-terminus of human β-Amyloid peptides detects several isoforms of β-amyloid peptide (Abeta), such as Abeta-40, Abeta-42 etc, regardless of phosphorylation state -
Innogenetics kit
Unknown Host
(well standardized multiparameter bead-based immunoassay for the simultaneous quantification of human ß-amyloid in plasma using xMAP® (registered trademark of Luminex Corp)technology)
ELISA Human Uses 3D6 antibody;3D6 selectively binds Aß peptides with a free aminogroup at Asp1 (epitope 1–5) for simultaneous quantification of different forms of β-amyloid in blood, with check for matrix interference -
Synaptic Systems monoclonal
IgG2b
Mouse
(affinity purified, buffered, azide, lyophilized)
IH, WB Human, Mouse, Rat Balb/c mice were immunized with a KLH-coupled pyroglutamate-Abeta-peptide with the peptide pE F R H D-C.After preparation of the lymph nodes, cells were fused with the myeloma cell line P3-963-Ag8 reactive to N-terminal truncated Abeta 3-X starting with pyroglutamate (pGlu, pE). Does not cross-react with N-terminal truncated Abeta 11-X starting with pGlu. -
Synaptic Systems monoclonal
IgG1
Mouse
(affinity purified, buffered, azide, lyophilized)
IH, WB Human, Mouse, Rat Balb/c mice were immunized with a KLH-coupled pyroglutamate-Abeta-peptide with the peptide pEFRHD-C.After preparation of the lymph nodes, cells were fused with the myeloma cell line P3-963-Ag8 reactive to N-terminal truncated Abeta 3-X starting with pyroglutamate (pGlu, pE). Does not cross-react with N-terminal truncated Abeta 11-X starting with pGlu. -
IBL
Cat# 10326
monoclonal
IgG1
Mouse
(affinity purified, lyophilized product from 1% BSA in PBS containing 0.05% NaN3; biotin-tagged)
IH, WB Human immunogen = synthetic peptide for human Amyloid β (1-16) (DAEFRHDS GYEVHHQK) Amyloid β and β-CTF N-terminal specific; reacts with both soluble and fibrillar Aβ to a similar degree; no reaction with holo-APP -
Biosensis
Cat# M-1586-100
monoclonal
IgG2b
Mouse
(Lyophilized; Protein A purified; 0.02 M potassium phosphate, 0.15 M sodium chloride, 0.01% sodium azide; pH 7.2)
DB, ELISA, IF, IH, IP, WB Human, Rat Epitope maps to residues 1-4 of human Aβ42 and Aβ40 (DAEF) Reacts with the N-terminal end of Aβ (amino acids 1-4). Appears to detect monomeric, oligomeric, and fibrillar forms of Aβ. Greater sensitivity for Aβ42 than Aβ40. Does not cross react with holo-APP or APP-CTFs. Confirmed available March 2015.
Abcam
Cat# ab126649
monoclonal
IgG2b
Mouse
(Protein G purified. PBS, 0.02% Sodium azide, pH: 7.40.)
IH Human Epitope maps to residues 1-4 of human Aβ42 and Aβ40 (DAEF) Reacts with the N-terminal end of Aβ (amino acids 1-4). Appears to detect monomeric, oligomeric, and fibrillar forms of Aβ. Greater sensitivity for Aβ42 than Aβ40. Does not cross react with holo-APP or APP-CTFs. Confirmed available March 2015.
Cayman Chemical
Cat# 11610
monoclonal
IgG2b
Mouse
(Purified IgG in PBS, pH 7.2, containing 50% glycerol, and 0.02% sodium azide)
ELISA, IC, IP, WB Human Epitope maps to residues 1-4 of human Aβ42 and Aβ40 (DAEF) Reacts with the N-terminal end of Aβ (amino acids 1-4). Appears to detect monomeric, oligomeric, and fibrillar forms of Aβ. Greater sensitivity for Aβ42 than Aβ40. Does not cross react with holo-APP or APP-CTFs. Confirmed available March 2015.
Kerafast
Cat# EB2001
monoclonal
IgG2b
Mouse
(Protein G purified; hepes buffered saline, pH 7.4, 50% glycerol)
ELISA, IC, IF, IH, IP, WB Human, Mouse, Rat Epitope maps to residues 1-4 of human Aβ42 and Aβ40 (DAEF) Reacts with the N-terminal end of Aβ (amino acids 1-4). Appears to detect monomeric, oligomeric, and fibrillar forms of Aβ. Greater sensitivity for Aβ42 than Aβ40. Does not cross react with holo-APP or APP-CTFs. Confirmed available March 2015.
Millipore
Cat# MABN254
monoclonal
IgG2aλ
Mouse
(Protein G purified; buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. )
IB, IC, IF, IH, IP, WB Human Epitope maps to residues 1-4 of human Aβ42 and Aβ40 (DAEF) Reacts with the N-terminal end of Aβ (amino acids 1-4). Appears to detect monomeric, oligomeric, and fibrillar forms of Aβ. Greater sensitivity for Aβ42 than Aβ40. Does not cross react with holo-APP or APP-CTFs. Confirmed available March 2015.
Novus Biologicals
Cat# NBP-2-13075
monoclonal
IgG2b
Mouse
(Protein G purified; Tris-glycine buffer with 150mM NaCl and 0.05% Sodium Azide; pH 7.5 )
ELISA, IB, IC, IF, IH, IP, WB Human, Mouse, Rat Epitope maps to residues 1-4 of human Aβ42 and Aβ40 (DAEF) Reacts with the N-terminal end of Aβ (amino acids 1-4). Appears to detect monomeric, oligomeric, and fibrillar forms of Aβ. Greater sensitivity for Aβ42 than Aβ40. Does not cross react with holo-APP or APP-CTFs. Confirmed available March 2015.
Dako
Cat# M0872
monoclonal
IgG1κ
Mouse
(Cell culture supernatant dialysed against 50 mmol/L Tris/HCl, pH 7.2, and containing 15 mmol/L NaN3)
ELISA, IC, IH Human immunogen = synthetic peptide consisting of residues 8-17 Aβ with additional C-terminal cysteine coupled to keyhole limpet hemocyanin (KLH) via the cysteine residue Targets extracellular β-amyloid in human brain parenchyma and cerebral vessels. Confirmed available June 2015
BioLegend monoclonal
IgG2b
Mouse
(liquid, PBS, no preservatives or carrier proteins, HRP conj.)
ELISA, IH, WB Human, Mouse epitope lies within amino acids 18-22 of the beta amyloid peptide (VFFAE) reactive to aa 17-24 Aβ and to APPs Available from BioLegend
BioLegend polyclonal
Rabbit
(liquid, PBS, no carrier protein or preservative, affinity purified)
ELISA, IH, WB - imunogen = using beta amyloid peptide (amino acids 1-16) conjugated to KLH reacts with all isoforms of beta amyloid Available from BioLegend
BioLegend monoclonal
IgG1
Mouse
(liquid, protein-A purified, PBS, no preservative or carrier proteins, AlexaFluor® labeled)
ELISA, IH Human the epitope lies within amino acids 4-9 of beta amyloid (FRHDSG) reactive to aa 1-17 Aβ reacts to the abnormally processed isoforms, as well as precursor forms Available from BioLegend
BioLegend monoclonal
IgG1
Mouse
(liquid, no preservatives or carrier proteins, purified)
ELISA, IH, WB Human epitope lies within amino acids 1-8 of the β-Amyloid protein reacts to N-terminal aa 1-8 of β-Amyloid peptide and β-amyloid form of APP Available from BioLegend
BioLegend monoclonal
IgG1
Mouse
(liquid, PBS, no preservative or carrier protein, affinity G purified)
ELISA, IB, IH, WB Human, Mouse - reactive to the C-terminus of beta amyloid and specific for the isoform ending at the 40th amino acid Available from BioLegend
BioLegend monoclonal
IgG1
Mouse
(liquid, PBS, no preservative or carrier proteins, protein A purified, biotinylated)
IH Human, Mouse - reactive to C-terminus of Amyloid β and specific for the isoform ending at the 40th amino acid -
BioLegend monoclonal
IgG1
Mouse
(liquid, PBS, no preservatives or carrier proteins, purified, conj. HRP)
IH Human - reactive to the C-terminus of beta amyloid and specific for the isoform ending at the 40th amino acid -
BioLegend monoclonal
IgG1
Mouse
(liquid, PBS, no preservative or carrier proteins, protein G purified IgG)
ELISA, IH, WB Human, Mouse - reactive to C-terminus of Amyloid β and specific for the isoform ending at the 42nd amino acid Available from BioLegend
BioLegend monoclonal
IgG1
Mouse
(liquid, PBS, biotin labelled)
ELISA, IH, WB Human, Mouse - reactive to C-terminus of Amyloid β and specific for the isoform ending at the 42nd amino acid Available from BioLegend
BioLegend monoclonal
IgG1
Mouse
(liquid, PBS, no preservative or carrier proteins, HRP conj.)
- Human, Mouse - reactive to C-terminus of Amyloid β and specific for the isoform ending at the 42nd aa Available from BioLegend
BioLegend monoclonal
IgG1
Mouse
(liquid, PBS no preservative or carrier proteins, IgG frac., protein A purified)
ELISA, IH, WB Human, Mouse - reactive to C-terminus of Amyloid β and specific for the isoform ending at the 43rd amino acid Available from BioLegend
BioLegend monoclonal
IgG1
Mouse
(liquid, PBS, no preservative or carrier protein, biotin conj.)
ELISA, IB, IH, IP, WB Human, Mouse epitope = lies within amino acids aa3-8 of beta amyloid (E F R H D S) reactive to the C-terminus of beta amyloid and specific for the isoform ending at the 43rd amino acid Available from BioLegend
BioLegend monoclonal
IgG1
Mouse
(liquid, PBS, purified)
ELISA, IH, IP, WB Rodent (various) - recognizes sequence of Aβ, β-CTF, sAPP-α, and full length APP; negligible cross reactivity with human isoforms of APP and beta amyloid. Available from BioLegend
BioLegend polyclonal
Rabbit
(liquid, PBS, no carrier protein or preservative, affinity purified)
ELISA, IH, WB Rodent (various) imunogen = rodent amyloid-β peptide conj. to KLH recognizes beta amyloid, all isoforms Available from BioLegend
BioLegend polyclonal
Rabbit
(liquid, PBS, glycerol, no carrier protein or preservative, boitin labeled)
ELISA, IH, WB Rodent (various) - all isoforms of rhodent Aβ Available from BioLegend
BioLegend monoclonal
IgG1
Mouse
(liquid, PBS; no preservatives or carrier proteins)
ELISA, IH, WB - epitope lies within amino acids 1-10 of beta amyloid amyloid β Available from BioLegend
BioLegend monoclonal
IgG1
Rabbit
(liquid, PBS, no carrier protein or preservative, affinity purified)
ELISA, IB, WB Human, Rodent (various) imunogen = beta amyloid peptide (aa1-16) conj. to KLH reactive to the C-terminus of beta amyloid and specific for the isoform that ends at the 40th amino acid Available from BioLegend
BioLegend polyclonal
Rabbit
(liquid, PBS, IgG fraction, no preservative or carrier protein)
IH Rodent (various) immunogen = rodent amyloid-β peptide rodent Amyloid-β ,all isoforms Available from BioLegend
None monoclonal
IgG1
Mouse
(liquid, PBS, no preservatives or carrier proteins, purified, HRP conj.)
ELISA, IH, WB Human epitope = lies within aa 3-8 of the β-amyloid peptide (EFRHDS) reactive to aa 1-16 of β-Amyloid (precursor forms as well as abnormally processed isoforms Discontinued
None monoclonal
IgG1
Mouse
(liquid, purified F(ab')2 frag of clone 6E10 monoclonal ab, PBS, no preservatives or carrier proteins)
ELISA, IH, WB Human epitope = lies within aa 3-8 of β-amyloid peptide (EFRHDS) reactive to aa 1-16 of β-amyloid peptide (precursor forms and abnormally processed isoforms) Discontinued
None monoclonal
IgG1
Mouse
(liquid, PBS; no preservatives or carrier proteins)
ELISA, IH, IP, WB Human epitope lies within amino acids 3-8 of the beta Amyloid peptide (E F R H D S) reactive to amino acid residue 1-16 of beta amyloid.; reacts to the abnormally processed isoforms, as well as precursor forms Discontinued
None monoclonal
Rabbit
(liquid, PBS, no carrier protein or preservative, purified)
ELISA - - reactive to the C-terminus of beta amyloid and specific for the isoform that ends at the 42nd amino acid. Discontinued
None polyclonal
IgG1
Rabbit
(liquid, PBS, glycerol, no preservative or carrier protein, affinity G purified, conj. biotin)
IB, IH, WB Human, Mouse immunogen = peptide conj. to KLH. specific for the C-terminus of Aβ 42; reacts extremely well with the 42 isoform; no cross-reaction with Aβ 40 or APP Discontinued
None polyclonal
IgG1
Rabbit
(liquid, PBS, no preservative or carrier protein, affinity G purified)
IB, IH, WB Human, Mouse immunogen = peptide conj. to KLH. specific for the C-terminus of Aβ 42; reacts extremely well with the 42 isoform; no cross-reaction with Aβ 40 or APP Discontinued
None polyclonal
IgG1
Rabbit
(liquid, PBS, glycerol, no preservative or carrier protein, conj. biotin)
IH Human, Mouse immunogen = peptide conj. to KLH. specific for the C-terminus of Aβ 42; reacts extremely well with the 42 isoform; no cross-reaction with Aβ 40 or APP Discontinued
None polyclonal
IgG
Rabbit
(purified, IgG fraction, PBS, no preservatives or carrier proteins)
IH Human, Mouse immunogen = amyloid β 1-42 peptide, conj. to KLH specific for the C-terminus of Aβ 1-42; no cross reaction with Aβ 1-40 or APP Discontinued
None polyclonal
Rabbit
(liquid, PBS, glycerol, no preservative or carrier proteins, affinity purified, bintinylated)
ELISA, IH, WB Human, Mouse immunogen = amyloid-β conj. to KLH specific for C-terminus of Aβ40 isoform; no cross-reaction with Aβ42 or APP Discontinued
None polyclonal
Rabbit
(liquid, PBS, glycerol, no preservative or carrier proteins, IgG frac., biotinylated)
IH Human immunogen = amyloid-β peptide conj. to KLH specific for C-terminus of Aβ 40 isoforms; no cross-reaction with Aβ 42 or APP Discontinued