Aβ38
anti-Aβ38(Pankaj Mehta,Department of Immunology, New York State Institute for Basic Research, Staten Island, New York)Paper: Potempska A, Mack K, Mehta PD, et al. Quantitation of sub-femtomole amounts of Alzheimer amyloid beta peptides. Amyloid: Int J Clin Invest 1999;16:14-21
kit
Unknown Host
(Sandwich ELISAmonoclonal antibody 6E10 (Signet Labs) is used as capture antibodyrabbit antiserum to Aβ38 is used as the detection antibody)
-
Human
immunogen (detection antibody) = peptide hCys-aminohexoanoyl-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-GlyOH
detects amyloid-beta 38; no reaction to Aβ40 or Aβ42
-
Aβ x-40, C terminal
αAβC40J. Buxbaum, Mt. Sinai School of Medicine, NewYork, NYPaperReferences:Hashimoto, 2010Lord, 2009Näslund, 2000
polyclonal
Rabbit
(serum)
-
Human, Mouse
immunogen = peptide corresponding to the 6 Cterminalresidues of Abx-40 and containing N-terminal cysteineresidues, coupled to KLH
recognizes amyloid-beta x-40
-
Aβ x-42, C terminal
αAβC42J. Buxbaum, Mt. Sinai School of Medicine, NewYork, NYPaperReferences:Hashimoto, 2010Lord, 2009Näslund, 2000
polyclonal
Rabbit
(serum)
-
Human, Mouse
immunogen = peptide corresponding to the 6 Cterminalresidues of Abx-42 and containing N-terminal cysteineresidues, coupled to KLH
recognizes amyloid-beta x-42
-
Aβ
2964(Jochen Walter,Department of Neurology, University of Bonn, Bonn,Germany)PaperReference: Heneka, 2010
polyclonal
Rabbit
-
Human, Mouse
immunogen = synthetic Aβ40
detects Aβ
-
Aβ fibrils, APP CTF (WO2)
WO2(Brian O'Nuallain,Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, TN)PaperReference: Villemagne, 2010
monoclonal
IgM
Mouse
-
Human, Mouse
raised against sonicated amyloid fibrils grown from synthesized Aβ1–40 peptides (epitope at Aβ residues 5–8)
detects amyloid-beta fibrils; exhibits Ab binding to fibrils in the presence of a large excess of Aβ(1–40) monomer, suggesting that Ab is directed against conformational epitopes that only exist in the fibril
-
Aβ fibrils (WO1)
-
monoclonal
IgM,κ
Mouse
-
Human, Mouse
raised against sonicated amyloid fibrils grown from synthesized Aβ1–40 peptides (epitope within aa 1-16)
detects amyloid-beta fibrils; exhibits binding to fibrils in the presence of a large excess of Aβ(1–40) monomer, suggesting it is directed against conformational epitopes that only exist in the fibril
-
Amyloid β42 (G2-11)
G2-11Konrad BeyreutherCenter for Molecular Biology Heidelberg (ZMBH), University of HeidelbergPaperReference: Villemagne, 2010
monoclonal
Mouse
(liquid, purified, PBS, BSAAlso see Chemicon MABN12)
-
Human, Mouse
immunogen = synthetic peptide corresponding to Aβ42, aa. 35-42 (MVGGVVIA), conjugated with KLH or BSA through a cysteine residue added at the N terminus of the peptides
recognizes Amyloid β42 at the C-terminus
-
Amyloid β40 (G2-10)
G2-10Konrad BeyreutherCenter for Molecular Biology Heidelberg (ZMBH), University of HeidelbergPaperReference: Villemagne, 2010
monoclonal
Mouse
(liquid, purified, PBS, BSAAlso see Chemicon MABN11)
-
Human, Mouse
immunogen = synthetic peptide corresponding to Aβ40, aa. 33-40 (GLMVGGVV), conjugated with KLH or BSA through a cysteine residue added at the N terminus of the peptides
recognizes Amyloid β40 at the C-terminus
-
Aβ 42
amyloid-beta R165(Pankaj Mehta,Department of Immunology, New York State Institute for Basic Research, Staten Island, New York)References: Chung, E, 2010Schupf, 2008Sigurdsson, 2001
polyclonal
Rabbit
(Sandwich ELISA)
-
-
amyloid-beta 42
-
Aβ 40
amyloid-beta R162(Pankaj Mehta,Department of Immunology, New York State Institute for Basic Research, Staten Island, New York)References: Chung, E, 2010Schupf, 2008Sigurdsson, 2001
polyclonal
Unknown Host
(Sandwich ELISA)
-
-
amyloid-beta 40
-
Aβ 40
anti-amyloid beta FCA3340(Frédéric Checler,Centre National de la Recherche Scientifique),PaperReference: Gandy, 2010
polyclonal
Rabbit
-
Human, Mouse
immunogen = synthetic octapeptide Cys-GLMVGGVV, mimicing the C-terminal end of Aβ 40, coupled to either BSA or KLH
amyloid-beta 40; labels leptomeningeal and cortical arterioles;little or no cross with Aβ 42
-
Aβ 42, C terminal
FCA3542(Frédéric Checler,Centre National de la Recherche Scientifique),PaperReferences:Gandy, 2010Lesné, 2006
polyclonal
Rabbit
(serum)
-
Human, Mouse
immunogen = synthetic octapeptide Cys-MVGGVVIA, mimicing the C-terminal end of Aβ 42, coupled to either BSA or KLH
recognizes amyloid-beta 42; little or no cross with Aβ 40; intensely labels both diffuse and mature lesions
-
Aβ42, murine
JRF/rAβ/2 (Paul Mathews, New York University, School of Medicine,Center for Dementia Research)Research paperReference: Boland, 2010
monoclonal
Mouse
(liquid, horseradish peroxidase conj.)
-
Mouse
immunogen = a peptide corresponding to murine Aβ residues 1–15 (DAEFGHDSGFEVRHQ)
recognizes mouse but not human Aβ1–40 or Aβ1–42
-
Aβ 1-40
JRF/Aβtot/17(Paul Mathews, New York University, School of Medicine,Marc Merken,Johnson & Johnson Pharm. R&D,paper)References:Gandy, 2010Trinchese, 2008Mi, 2007
monoclonal
Mouse
-
Human
immunogen = human Aβ1-40
amyloid-beta, binds within residues 1-15
-
Aβ 1-15
JRF/rAβ1-15/2(Paul Mathews, New York University, School of Medicine,Marc Merken,Johnson & Johnson Pharm. R&D,paper)References:Gandy, 2010
monoclonal
Mouse
-
Mouse
epitope within residues 1-15 of mouse Aβ
binds to amyloid-beta
-
Aβ 40, C-terminus
JRF/cAβ40/10(Paul Mathews, New York University, School of Medicine,Marc Mercken,Johnson & Johnson Pharm. R&D,Paper)References:Boland, 2010Trinchese, 2008Mi, 2007Razmahel, 2002
monoclonal
Mouse
-
Human, Mouse
immunogen = a peptide corresponding to Aβ residues 36–40 (VGGVV)
recognizes the carboxyl terminus of Aβ40; does not detect Aβ1–42 by ELISA or WB, or full-length APP by IP or WB
-
Aβ 42, C-terminal
JRF/cAβ42/26(Marc Mercken,Johnson & Johnson Pharm. R&D,Paper)References:Boland, 2010Trinchese, 2008Mi, 2007Razmahel, 2002
monoclonal
Mouse
-
Human, Mouse
immunogen = the carboxy terminal 10 residues of Ab1-42
amyloid-beta 42, C-terminus
-
Aβ[4-10] and APPβ (W0-2)
(Konrad Beyreuther, Center of Molecular Biology, University of Heidelberg, Heidelberg, Germany)PaperReference: Kuhn, 2010
monoclonal
IgG2a
Mouse
-
Human, Guinea Pig
immunogen = decapeptides overlapping each other by one aminoacid, covering residues 1-42 of Aβ (epitope mapping corr. to amino acid residues 4-10 of human Aβ-peptide)
High affinity to Amyloid peptides Aβ 1-38, Aβ 1-39, Aβ 1-40
-
Aβ
3552(Harald Steiner,Laboratory for Alzheimer’s and Parkinson’s Disease Research, Adolf ButenandtInstitute, Ludwig Maximilians University, Munich, Germany)PaperReference: Kuhn, 2010
polyclonal
Unknown Host
-
Human
immunogen = Aβ1–40
recognizes amyloid-beta
-
Soluble Amyloid Oligomers
A11(paper comparing A11 and OC antibodies;source paper for A11; Charles G Glabe, University of California, Irvine)References:Lefterov, 2010
polyclonal
Rabbit
(serum)
-
Human
immunogen = soluble Amyloid oligomers
generic epitope common to prefibrillar oligomers and not fibrils, monomers or natively folded precursor proteins. Stains small focal or punctuate deposits in AD tissue does not stain diffuse plaques or other plaque types. Stains Aβ and polyQ prefibrillar oligomers.
-
Amyloid fibrils and fibrillar oligomers
OC(paper on antibodies;paper on oligimerization; Charles G Glabe, University of California, Irvine)References:Lefterov, 2010Clinton, 2010Blurton-Jones, 2009
polyclonal
Rabbit
(serum)
-
Human
immunogern = a morphologically homogeneous population of Aβ42 fibrils
specifically recognizes fibrils, but not random coil monomer or prefibrillar oligomers; also recognizes 100,000 × G soluble fibrillar oligomers ranging in size from dimer to greater than 250 kDa on western blots. The fibrillar oligomers recognized by OC are immunologically distinct from prefibrillar oligomers recognized by A11, even though their sizes overlap broadly
-
Aβ 1-16
IC16(Claus U. Pietrzik,Institute of Physiological Chemistry and Pathobiochemistry, MolecularNeurodegeneration, Johannes-Gutenberg-University Mainz, Mainz, Germany)paper)Reference: Richter L, 2010
monoclonal
Mouse
-
Human
immunogen = synthetic human Ab peptide 1–16, cross-linked to keyhole limpet hemocyanin
recognizes residues 1-16 of Amyloid β. Hybridoma cells were generated by standard procedures and screened for recognition of HSA cross-linked to Ab 1-16by ELISA; recognition of synthetic Ab 1–42 ona standardized dot blot procedure was confirmed and the epitope mapped to Ab 1–8 using a peptide array spanning the entire sequence of Ab
-
Aβ 40, C-terminus
BAP-17(Manfred Brockhaus, F. Hoffmann-La Roche Ltd., Basel,Paper)
monoclonal
IgG1
Mouse
(purified from spent hybridoma medium and conjugated to horseradish peroxidase)
-
Human
immunogen = the peptide CMVGGVV conjugatedto keyhole limpet hemocyanin
specific for Aβ40; no cross-reactivity observed with Ab39, Ab42 or Ab43. Ab41 showed a signal accounting for about10% of the cognate Ab40 signal
-
Amyloid-β 42
Meso Scale Discovery
kit
Mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 42 Antibody 4G8, protocol)
-
Human, Mouse, Rat
-
reactive to beta Amyloid 42 peptide
-
Amyloid-β 42
Meso Scale Discovery
kit
Mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 42 Antibody 4G8, protocol)
-
Human, Mouse, Rat
-
reactive to human beta Amyloid 42 peptide
-
Amyloid-β 42
Meso Scale Discovery
kit
Mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 42 Antibody 4G8, protocol)
-
Human, Mouse, Rat
-
reactive to beta Amyloid 42 peptide
-
Amyloid-β 42
Meso Scale Discovery
kit
Mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 42 Antibody 4G8, protocol)
-
Human, Mouse, Rat
-
reactive to human beta Amyloid 42 peptide
-
Amyloid beta 1-16 (AB10)
Chemicon and Upstate are Millipore
monoclonal
IgG1
Mouse
(liquid, supernatant, azide)
-
Bovine, Human, Monkey
immunogen = amyloid-β 1-16 conjugated to KLH
amyloid-β 1-16
-
Amyloid β and APP (W0-2)
Chemicon and Upstate are Millipore
monoclonal
IgG2a , κ
Mouse
(liquid, Tris-glycine saline, azide, protein G purified)
-
Human, Mouse
immunogen = human beta amyloid peptide (epitope at aa 4-10)
recognizes amino acid residues 4-10 of human Amyloid β, can also show 120 and 105 kDa APP proteins, and ~45 kDa oligomers of amyloid proteins on our western blot of human Alzheimer diseased brain lysate
-
Aβ[4-10] and APPβ (W0-2)
Genetics Company, Inc.
monoclonal
IgG2a ,κ
Mouse
(biotinylated supernatant IgG, stabilizing solution, no azide, affinity purified)
-
Human
N-terminal: Epitope mapping corr. to amino acid residues 4-10 of human Aβ-peptide
High affinity to Amyloid peptides Aβ 1-38, Aβ 1-39, Aβ 1-40, Aβ 1-43 and Aβ 1-44
-
Aβ[4-10] and APPβ (W0-2)
Genetics Company, Inc.
monoclonal
IgG2a ,κ
Mouse
(peroxidase, supernatant IgG, stabilizing solution, no azide, affinity purified)
-
Human
N-terminal: Epitope mapping corr. to amino acid residues 4-10 of human Aβ-peptide
High affinity to Amyloid peptides Aβ 1-38, Aβ 1-39, Aβ 1-40, Aβ 1-43 and Aβ 1-44
-
β-Amyloid (1E11)
BioLegend
monoclonal
IgG1
Mouse
(liquid, no preservatives or carrier proteins, purified)
-
Human
epitope lies within amino acids 1-8 of the β-Amyloid protein
reacts to N-terminal aa 1-8 of β-Amyloid peptide and β-amyloid form of APP
Available from BioLegend
Amyloid Beta 1-40
Wako Chemicals
kit
Mouse
(96 tests:BAN50/BA27(Fab') antibodies from Takeda Chemical Industries.range: 1.0~100 pmol/L)
-
Human
Aβ (1-40); detects the N-terminal of Aβ
-
Amyloid Beta 1-40
Wako Chemicals
kit
Mouse
(96 tests:BAN50/BA27(Fab')2 , HRP conj. antibodies from Takeda Chemical Industries.range: 1.0~100 pmol/L.Achieved stable antigen-antibody reaction)
-
Human
achieves more stable antigen-antibody reactions by using F(ab' )2 fragment of the labeled antibody BA27, which recognizes the C-terminal of beta Amyloid 40, while the nonspecific binding is remaining to be reduced
Aβ (1-40); detects the C-terminal
-
Amyloid Beta 1-42
Wako Chemicals
kit
Mouse
(96 tests:BAN50/BC05(Fab') HRP conj. antibodies from Takeda Chemical Industries.range: 1.0~100 pmol/L.)
-
Human
detects C-terminal of Aβ 42
-
Amyloid Beta Staining Kit (BA27, BC05)
Wako Chemicals
monoclonal
Mouse
(50 tests: This kit stains Aβ40 or Aβ42 in tissue section bythe monoclonal antibodies that detects the portionof C-terminal of Aβ.)
-
-
distinctive staining of Aβ(1-40) and Aβ(1-42) plaques
-
Amyloid Beta x-40
Wako Chemicals
kit
Mouse
(96 tests:BNT77/BA27(Fab') HRP conj. antibodies from Takeda Chemical Industries.range: 1.0~100 pmol/L)
-
Human, Mouse, Rat
BNT77: Specifically detects the Aβ (11-28) of AβBA27: Specifically detects the C-terminal of Aβ 40
detects Aβ (x-40), with a truncated or modified N-terminus
-
β-Amyloid 1-16 or APP (6E10)
None
monoclonal
IgG1
Mouse
(liquid, PBS, no preservatives or carrier proteins, purified, HRP conj.)
-
Human
epitope = lies within aa 3-8 of the β-amyloid peptide (EFRHDS)
reactive to aa 1-16 of β-Amyloid (precursor forms as well as abnormally processed isoforms
Discontinued
Amyloid β 42
Invitrogen Corporation
polyclonal
Rabbit
(liquid, affinity purified, rabbit polyclonal immunoglobulins in phosphate buffer, pH 7.4. Carrier and preservative free)
-
Human
immunogen = synthetic peptide derived from amino acids 36-42 within the carboxyl-terminus region of human β-Amyloid protein
Reacts with human Aβ42. No significant cross-reactivity to Aβ40 or Aβ43 has been observed
-
Amyloid β 40
Invitrogen Corporation
polyclonal
Rabbit
(liquid, affinity purified, rabbit polyclonal immunoglobulins in phosphate buffer, pH 7.4. Carrier and preservative free)
-
Human
immunogen = synthetic peptide derived from amino acids 34-40 within the carboxyl-terminus region of human β-Amyloid protein
Reacts with human Aβ40. No significant cross-reactivity to Aβ42 or Aβ43 has been observed
-
Amyloid β 43
Invitrogen Corporation
polyclonal
Rabbit
(liquid, affinity purified, rabbit polyclonal immunoglobulins in phosphate buffer, pH 7.4. Carrier and preservative free.Any reactivity to Aβ40 or Aβ42 eliminated through a series of preabsorption steps)
-
Human
-
Reacts with human Aβ43. No significant cross-reactivity to Aβ40 or Aβ42
-
Amyloid β 1-42
Invitrogen Corporation
polyclonal
Rabbit
(liquid, affinity purified, PBS, azide.Any reactivity to Aβ40 or Aβ42 eliminated through a series of preabsorption steps.Biotin conj.)
-
Human, Mouse, Rat
-
Reacts with human Aβ42. No significant cross-reactivity to Aβ1-40 or Aβ1-43 has been observed
-
Amyloid β, N-terminal
Invitrogen Corporation
polyclonal
Rabbit
(Processed whole rabbit serum, azide.can routinely be used without further purification)
-
Human
immunogen = synthetic peptide corresponding to aa sequence 1-14 (DAEFRHDSGYEVHH) of the human amyloid β protein
recognizes Amyloid β; will discriminate amyloid β from other CNS amyloids
-
β-Amyloid (M3.2)
BioLegend
monoclonal
IgG1
Mouse
(liquid, PBS, purified)
-
Rodent (various)
-
recognizes sequence of Aβ, β-CTF, sAPP-α, and full length APP; negligible cross reactivity with human isoforms of APP and beta amyloid.
Available from BioLegend
β-Amyloid 1-40 (11A50-B10)
BioLegend
monoclonal
IgG1
Mouse
(liquid, PBS, no preservative or carrier protein, affinity G purified)
-
Human, Mouse
-
reactive to the C-terminus of beta amyloid and specific for the isoform ending at the 40th amino acid
Available from BioLegend
β-Amyloid 1-43 (9C4)
BioLegend
monoclonal
IgG1
Mouse
(liquid, PBS, no preservative or carrier protein, biotin conj.)
-
Human, Mouse
epitope = lies within amino acids aa3-8 of beta amyloid (E F R H D S)
reactive to the C-terminus of beta amyloid and specific for the isoform ending at the 43rd amino acid
Available from BioLegend
β-Amyloid 42
None
polyclonal
IgG1
Rabbit
(liquid, PBS, no preservative or carrier protein, affinity G purified)
-
Human, Mouse
immunogen = peptide conj. to KLH.
specific for the C-terminus of Aβ 42; reacts extremely well with the 42 isoform; no cross-reaction with Aβ 40 or APP
Discontinued
β-Amyloid 42
None
polyclonal
IgG1
Rabbit
(liquid, PBS, glycerol, no preservative or carrier protein, affinity G purified, conj. biotin)
-
Human, Mouse
immunogen = peptide conj. to KLH.
specific for the C-terminus of Aβ 42; reacts extremely well with the 42 isoform; no cross-reaction with Aβ 40 or APP
Discontinued
β-Amyloid 42
None
polyclonal
IgG1
Rabbit
(liquid, PBS, glycerol, no preservative or carrier protein, conj. biotin)
-
Human, Mouse
immunogen = peptide conj. to KLH.
specific for the C-terminus of Aβ 42; reacts extremely well with the 42 isoform; no cross-reaction with Aβ 40 or APP
Discontinued
β-Amyloid 1-40
None
polyclonal
Rabbit
(serum)
-
Human
-
recognizes Amyloid beta 1-40; some (minimal) cross-reactivity to Amyloid beta 1-42
Discontinued
β-Amyloid 1-40 and 1-42
None
polyclonal
Rabbit
(affinity purified, PBS, BSA, thimerosol)
-
Dog, Human, Chicken
-
recognizes Amyloid beta 1-42 and 1-40
Discontinued
β-Amyloid 1-42
None
polyclonal
Rabbit
(serum)
-
Human
-
recognizes Amyloid beta 1-42; some (minimal) cross-reactivity to Amyloid beta 1-40
Discontinued
β-Amyloid 1-42
None
kit
Unknown Host
(Chemiluminescent sandwich ELISA Kit: Capture Antibody Coated Plate; HRP Detection Antibody, chemiluminescent substrate)
-
Human
-
specific for the 1-42 isoform of beta amyloid; has negligible cross reactivity with the 1-40 isoform of beta amyloid
Discontinued
β-Amyloid x-42
BioLegend
kit
Unknown Host
(Colorimetric sandwich: Capture Antibody Coated Plate; HRP Detection Antibody; TMB substrate)
-
Human, Rodent (various)
-
specific for the x-42 isoform of beta amyloid; negligible cross reactivity with the x-40 isoform of beta amyloid
Available from BioLegend
β-Amyloid (NAB228)
None
monoclonal
IgG2a
Mouse
(liquid, ascites)
-
Human
immunogen = beta-amyloid (epitope at amino terminus,aa 1-11)
recognizes the Amyloid beta (Aß) 1-11 of the human beta amyloid peptide; also recognizes full length APP, sAPP species excluding sAPPß, C99 and Aß
Discontinued
β-Amyloid x-42
None
kit
Unknown Host
(Chemiluminescent sandwich ELISA Kit: Capture Antibody Coated Plate; HRP Detection Antibody, chemiluminescent substrate)
-
Human, Rodent (various)
-
specific for the x-42 isoform of beta amyloid; has negligible cross reactivity with the x-40 isoform of beta amyloid
Discontinued
β-Amyloid 1-40
None
kit
Unknown Host
(Chemiluminescent sandwich ELISA Kit: Capture Antibody Coated Plate; HRP Detection Antibody, chemiluminescent substrate)
-
Human
-
reactive to Aβ; specific for the 1-40 isoform of beta amyloid; has negligible cross reactivity with the 1-42 isoform of beta amyloid
Discontinued
β-Amyloid 1-40
None
kit
Unknown Host
(sandwich ELISA kit: capture, primary and secondary antibody-HRP)
-
-
-
reactive to Aβ 1-40
Discontinued
β-Amyloid 1-42
None
kit
Unknown Host
(Sandwich ELISA Kit: Coated Capture Antibody; Primary Antibody; Secondary Antibody-HRP)
-
-
-
specific for Aβ 1-42
Discontinued
β-Amyloid x-40
None
kit
Unknown Host
(Chemiluminescent sandwich ELISA Kit: Capture Antibody Coated Plate; HRP Detection Antibody, chemiluminescent substrate)
-
Human, Rodent (various)
-
reactive to the x-40 isoform of beta amyloid; has negligible cross reactivity with the x-42 isoform of beta amyloid
Discontinued
β-Amyloid x-40
BioLegend
kit
Unknown Host
(Colorimetric sandwich ELISA Kit: Capture Antibody Coated Plate; HRP Detection Antibody; TMB substrate)
-
Human, Rodent (various)
-
reactive to Amyloid β x-40; negligible cross reactivity with the x-42 isoform of beta amyloid
Available from BioLegend
hAmyloid β40, brain
Genetics Company, Inc.
kit
Unknown Host
(Solid phase sandwich ELISA test, detection range of 25-500pg/ml, low sampla volumes)
-
Human, Guinea Pig, Mouse
Monoclonal detection and capture antibodies
selective determination ofhuman Amyloid b40 (hAb40) in brain samples and for other tissue samples.; reliable, quantitative determination of human Amyloid b40 peptides in brain homogenates.
-
hAmyloid β42, brain
Genetics Company, Inc.
kit
Unknown Host
(Solid phase sandwich ELISA test, detection range of 25-500pg/ml, low sampla volumes)
-
Human, Guinea Pig, Mouse
Monoclonal detection and capture antibodies
selective determination ofhuman Amyloid b42 (hAb42) in brain samples and for other tissue samples.; reliable, quantitative determination of human Amyloid b42 peptides in brain homogenates.
-
hAmyloid β40 (-kit,mono)
Genetics Company, Inc.
kit
Unknown Host
(Solid phase sandwich ELISA test, detection range of 100-2000pg/ml)
-
Human
Monoclonal detection and capture antibodies
Aβ 40 in CSF; not Aβ 1-38, Aβ 1-39, Aβ 1-42, Aβ 1-43 or Aβ 1-44
-
hAmyloid β42 (-kit,mono)
Genetics Company, Inc.
kit
Unknown Host
(Solid phase sandwich ELISA test, detection range of 100-2000pg/ml)
-
Human
Monoclonal detection and capture antibodies
Aβ 42 in CSF; not Aβ 1-38, Aβ 1-39, Aβ 1-40; low cross reactivity with Aβ 1-43 (13%), Aβ 1-44 (10%)
-
Amyloid β42
Biosource Invitrogen
polyclonal
Rabbit
(affinity purified serum, PBS, carrier and preservative free, unconj.)
-
Human, Mouse, Rat
specific to Amyloid β42; not Amyloid β40 or Amyloid β43
-
β-Amyloid 1-16 or APP (6E10)
None
monoclonal
IgG1
Mouse
(liquid, PBS; no preservatives or carrier proteins)
-
Human
epitope lies within amino acids 3-8 of the beta Amyloid peptide (E F R H D S)
reactive to amino acid residue 1-16 of beta amyloid.; reacts to the abnormally processed isoforms, as well as precursor forms
Discontinued
Amyloid beta [1-42]
Chemicon and Upstate are Millipore
polyclonal
Rabbit
(liquid, tris, BSA, azide, affinity purified)
-
Human, Mouse
immunogen = a 6 aa peptide sequence from the C-terminal of human β-amyloid 1-42.
β-amyloid 1-42
-
Amyloid Beta 1-40
Wako Chemicals
kit
Mouse
(96 tests:BNT77/BA27(Fab') HRP conj. antibodies from Takeda Chemical Industries.range: 1.0~100 pmol/L.)
-
Human, Mouse, Rat
detects C-terminal of Aβ 40
-
Amyloid Beta 42, high-sensitive
Wako Chemicals
kit
Mouse
(96 tests: BNT77/BC05(Fab') HRP conj. antibodies from Takeda Chemical IndustriesDetection sensitivity of the kits isabout 10 times higher than that of the conventional products and the dynamic range is from 0.1 to 20.0 pmol/L. Fab' fragment of the labeled antibody is used as well so that the nonspecific binding is reduced)
-
Human, Mouse, Rat
BNT77: Specifically detects the Aβ (11-28) of AβBC05: Specifically detects the C-terminal of Aβ 42
detects Aβ (1-42) and Aβ (x-42)
-
Amyloid beta
Upstate and Chemicon are Millipore
kit
Unknown Host
(AB1518SP anti-neurofibrillary tangles; MAB1561SP anti-amyloid, beta, juxtamembrane EC domain, clone 4G8; MAB5206SP anti-amyloid, beta 1-16, clone DE2)
-
-
3 antibodies in package
detects amyloid beta
-
β-Amyloid 1-42 (12F4)
BioLegend
monoclonal
IgG1
Mouse
(liquid, PBS, no preservative or carrier proteins, protein G purified IgG)
-
Human, Mouse
-
reactive to C-terminus of Amyloid β and specific for the isoform ending at the 42nd amino acid
Available from BioLegend
Amyloid β40 (G2-10)
Chemicon and Upstate are Millipore
monoclonal
IgG2b ,κ
Mouse
(liquid, purified, buffer, Tris-glycine, BSA, azide)
-
Human, Mouse
immunogen = linear peptide of human Amyloid β40 at the C terminus
recognizes Amyloid β40 at the C-terminus
-
β-Amyloid 1-16 (2C8)
Stressgen Enzo Life Sciences
monoclonal
IgG2b
Mouse
(PBS, glycerol, azide, protein A purified)
-
Human, Mouse
immunogen = synthetic peptide derived from sequence near the amino-terminus of human Amyloid β
Amyloid β (4-5kDa), N-terminal of β-Amyloid 40/42; no reaction with recombinant APP
-
β-Amyloid A4, 1-40 (5C3)
Stressgen Enzo Life Sciences
monoclonal
IgG1
Mouse
(purified, PBS, azide, PEG, sucrose, lyophilized)
-
Human
immunogen = C-terminal peptide conjugated to KLH; C-Terminus of Amyloid beta-A4 (1-40)
reactive to C-terminus of Amyloid β 1-40; does not cross-react with Amyloid β (1-42)
-
β-Amyloid A4, 1-42 (8G7)
Stressgen Enzo Life Sciences
monoclonal
IgG1
Mouse
(purified, PBS, azide, PEG, sucrose, lyophilized)
-
Human
immunogen = C-terminal peptide conjugated to KLH; C-Terminus of Amyloid beta-A4 (1-42)
reactive to C-terminus of Amyloid β 1-42; no cross-reaction with Amyloid β (1-40)
-
β-Amyloid A4, 40/42 (9F1)
Stressgen Enzo Life Sciences
monoclonal
IgG1
Mouse
(lyophilized, purified, PBS, azide, PEG, sucrose)
-
Human
immunogen = C-terminal peptide conjugated to KLH; C-Terminus of Amyloid beta-A4 (1-40, 1-42)
Amyloid β 40/42; cross reacts with APP
-
Amyloid β (16E9)
Stressgen Enzo Life Sciences
monoclonal
IgG2a , κ
Mouse
(liquid, PBS, azide, protein A/G affinity purified)
-
Human
immunogen = human amyloid beta-peptide aa 5-16, R H D S G Y E V H H Q K, coupled to carrier
Amyloid β (5-16)
-
Amyloid β (19B8)
Stressgen Enzo Life Sciences
monoclonal
IgG2a , κ
Mouse
(liquid, PBS, azide, protein A/G affinity purified)
-
Human
immunogen = human amyloid beta-peptide aa 5-16, R H D S G Y E V H H Q K, coupled to carrier
recognizes Amyloid β
-
Amyloid β (1A3)
Stressgen Enzo Life Sciences
monoclonal
IgG2a , κ
Mouse
(liquid, PBS, azide, protein A/G affinity purified)
-
Human
immunogen = human amyloid beta-peptide aa 5-16, R H D S G Y E V H H Q K, coupled to carrier
Amyloid β
-
Amyloid β (aa5-16) (12C3)
Stressgen Enzo Life Sciences
monoclonal
IgG1 , κ
Mouse
(liquid, PBS, azide, protein A/G affinity purified)
-
Human
immunogen = synthetic human amyloid beta-peptide aa 5-16, R H D S G Y E V H H Q K, coupled to carrier
amyloid beta
-
Amyloid-β (6F/3D)
DAKO Cat# M0872
monoclonal
IgG1 κ
Mouse
(Cell culture supernatant dialysed against 50 mmol/L Tris/HCl, pH 7.2, and containing 15 mmol/L NaN3)
-
Human
immunogen = synthetic peptide consisting of residues 8-17 Aβ with additional C-terminal cysteine coupled to keyhole limpet hemocyanin (KLH) via the cysteine residue
Targets extracellular β-amyloid in human brain parenchyma and cerebral vessels.
Confirmed available June 2015
Aβ 40 (G2-10)
Genetics Company, Inc.
monoclonal
IgG2b ,κ
Mouse
(affinity purified IgG, PBS, azide)
-
Dog, Human, Guinea Pig, Mouse, Rat, Cynomolgus
C-terminal epitope mapping corr. to amino acid residue 31-40 of human Aβ peptide
recognizes Aβ-peptide, aa 31-40; selective for C-terminal of Aβ- 1-40; not Aβ 1-38, Aβ 1-39, Aβ 1-42, Aβ 1-43 or Aβ 1-44
-
β-Amyloid 1-16 or APP (6E10)
BioLegend
monoclonal
IgG1
Mouse
(liquid, protein-A purified, PBS, no preservative or carrier proteins, AlexaFluor® labeled)
-
Human
the epitope lies within amino acids 4-9 of beta amyloid (FRHDSG)
reactive to aa 1-17 Aβ reacts to the abnormally processed isoforms, as well as precursor forms
Available from BioLegend
Amyloid β, aggregated
Biosource Invitrogen
kit
Unknown Host
(solid phase sandwich ELISA, capture and (same) detection antibody, SAV-HRP, colorimetric.sensitivity of this assay is )
-
Human
-
Recognizes aggregated Aβ in homogenates, ventricular fluid, CSF, tissue culture supernatant, and buffered solution samples
-
Aβ soluble Oligomers
Biosource Invitrogen
polyclonal
Ig
Rabbit
(liquid, affinity purified, PBS, azide)
-
Human
immunogen = synthetic molecular mimic of soluble oligomers
A11 recognizes amino acid sequence independent oligomers of proteins and peptides, including Aβ40 and Aβ42; not monomers or mature fibers of proteins or peptides
-
Amyloid β
Acanthus Research
polyclonal
IgG1
Rabbit
(liquid, serum)
-
Human, Mouse
immunogen = synthetic peptide corresp. to 1-8 amino acid residuesfrom N-terminus of human Amyloid Betaprotein, conjigated with a carrier protein
reactive to the N-terminal region (a.a. residues 1-8) ofAmyloid Beta peptide
-
Amyloid β pE3 (2G6)
Acanthus Research
monoclonal
IgG1
Mouse
(liquid, ascites, azide free)
-
Human, Mouse, Rat
immunogen = (3-8) N-terminal pyroglutamated synthetic amyloid beta peptide conjigated with a carrier protein
reactive to N-terminal truncated Ab starting with pyroglutamate (pGlu, pE)
-
Amyloid beta[1-42]
IBL
kit
Unknown Host
(solid phase sandwich ELISA using 2 kinds of high specific antibodies, range of 12.5 pg/ml ~ 800 pg/ml. Precoated plate with Aβ(38-42) Rabbit IgG; labeled antibody Anti-Human Aβ(11-28) Mouse IgG)
-
Human
-
quantitative determination of human A β (1-42) in cerebrospinal fluid, cellculture media or the extract from brain tissue, both recombinant and native forms of human Aβ(1-42)
-
Amyloid beta[1-40]
IBL
kit
Unknown Host
(solid phase sandwich ELISA, using 2 kinds of highly specific antibodies; range of 7.8 pg/ml ~ 500 pg/ml. Precoated plate with monoclonal 1A10, and labeled antibody 12B2)
-
Human
-
quantitative determination of human Aβ(1-40) in EDTA-plasma, cerebrospinal fluids, serum, cell culture media or the extract from brain tissue; both recombinant and native forms of human Aβ(1-40), and little cross with (1-42) or (1-43)
-
Amyloid Beta 40
Wako Chemicals
kit
Mouse
(96 tests:BNT77/BA27(Fab')2 , HRP conj. antibodies from Takeda Chemical Industries.range: 1.0~100 pmol/L.Achieved stable antigen-antibody reaction)
-
Human, Mouse, Rat
achieves more stable antigen-antibody reactions by using F(ab' )2 fragment of the labeled antibody BA27, which recognizes the C-terminal of beta Amyloid 40, while the nonspecific binding is remaining to be reduced
detects the C-terminal of Aβ (1-40) and Aβ (x-40)
-
Amyloid Beta 42
Wako Chemicals
kit
Mouse
(96 tests: BNT77/BC05(Fab') HRP conj. antibodies from Takeda Chemical Industries. range: 1.0~100 pmol/L)
-
Human, Mouse, Rat
BNT77: Specifically detects the Aβ (11-28) of AβBC05: Specifically detects the C-terminal of Aβ 42
detects Aβ (1-42) and Aβ (x-42)
-
Amyloid β [1-42]
Innogenetics
kit
Mouse
-
Human
Uses 21F12 as a capture antibody and incubation with biotinylated 3D6; 3D6 selectively binds Aß peptides with a free aminogroup at Asp1 (epitope 1–5)
amyloid beta (cerebrospinal fluid)
-
Amyloid β1-42 (H31L21)
Biosource Invitrogen
monoclonal
IgG
Rabbit
(liquid, PBS, azide)
-
Human, Mouse
immunogen = peptide (VGGVVIA) corresp. to aa707-713 of P05067
specific to Amyloid β1-42; not Amyloid β1-40, Amyloid β1-43, Amyloid β1-37 or Amyloid β1-38
-
Amyloid β42 (20-1)
Biosource Invitrogen
monoclonal
IgG
Rabbit
(liquid, PBS, azide, protein A purified)
-
Human
immunogen = aa residues from the C-terminus of human amyloid beta A4 protein
specific to Amyloid β42; no cross reaction with Amyloid beta 1-40
-
Aβ
-
monoclonal
(supernat, RIA screened, HPLC purified)
-
-
immunogen = synthetic peptide fragment derived from different regions of amyloid-beta and coupled to a carrier protein
amyloid-beta
-
Aβ 40 (G2-10)
Genetics Company, Inc.
monoclonal
IgG2b ,κ
Mouse
(liquid, supernatant, stabilizing solution, affinity purified, conj. HRP)
-
Dog, Human, Guinea Pig, Mouse, Rat, Cynomolgus
C-terminal epitope mapping corr. to amino acid residues 31-40 of human Aβ peptide
recognizes Aβ-peptide, aa 31-40; selective for C-terminal of Aβ 1-40; not Aβ 1-38, Aβ 1-39, Aβ 1-42, Aβ 1-43 or Aβ 1-44
-
Aβ 42 (G2-13)
Genetics Company, Inc.
monoclonal
IgG1 ,κ
Mouse
(liquid, stabilizing solution, no azide, affinity purified, conj. HRP)
-
Dog, Human, Guinea Pig, Mouse, Rat, Cynomolgus
immunogen = Aβ 1-42 peptide at the C-terminus
C-terminal of Aβ 1-42 peptide; not Aβ 1-38, Aβ 1-39, Aβ 1-40; low cross reactivity to Aβ 43 (10%)and Aβ 44 (13%)
-
Aβ[4-10] and APPβ (W0-2)
Genetics Company, Inc.
monoclonal
IgG2a ,κ
Mouse
(supernatant IgG, Tris, azide, affinity purifiedAlso available Biotin or peroxidase conjugated)
-
Human
N-terminal: Epitope mapping corr. to amino acid residues 4-10 of human Aβ-peptide
High affinity to the N-terminal of human Amyloid β peptides Aβ 1-38, Aβ 1-39, Aβ 1-40, Aβ 1-43 and Aβ 1-44
-