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Antibodies

29333 Results

Name Source Clonality &
Isotype
Host &
Formulation
Method Reactivity Immunogen/
Epitope
Specificity Availability
APP, APLP, AICD From labs (1)
(Stefan Lichtenthaler, Adolf Butenandt Institute, Ludwig Maximilians University, München, Germany)Paper, Ulrich et al.Reference: Kuhn, 2010 monoclonal
IgG2a
Mouse
IP, WB Human immunogen = the peptide ISEVKM derived from the amino acids directly preceding the APPβ-secretase cleavage site detects APPsβ at the β cleavage site -
APP, APLP, AICD From manufacturers (4)
None kit
IgG1
Rabbit
ELISA Human, Mouse, Rat immunogen = synthetic peptide corresp. to aa 573-596 of APP (amyloid precursor protein) specific for the β isoform of sAPP (soluble amyloid precursor protein). It has negligible cross reactivity with β amyloid 40, 42, or sAPPα Discontinued
BioLegend polyclonal
Rabbit
(affinity purified, PBS, no preservatives or carrier proteins)
ELISA - - reactive to C-terminal fragment of APP (APPc) Available from BioLegend
BioLegend monoclonal
IgG1
Mouse
(Purified by affinity chromatography. PBS, no preservatives or carrier proteins.)
ELISA, IB, IC, IF, IH, IP, WB Human epitope lies within amino acids 3-8 of beta amyloid (EFRHDS) reactive to aa 1-16 Aβ and to APP; reacts to the abnormally processed isoforms, as well as precursor forms Available from BioLegend
Abcam monoclonal
IgG1
Mouse
(liquid, protein-G purified, PBS, Thimerosal)
ELISA, IH, IP, WB Human immunogen = synthetic peptide, corresp. to aa 1-17 of human β-Amyloid, with Glu substituted at position 11, conj. to KLH recognizes beta amyloid peptide, the precursor and the abnormally processed isoforms No longer available.
Amyloid-β From labs (1)
A11(paper comparing A11 and OC antibodies;source paper for A11; Charles G Glabe, University of California, Irvine)References:Lefterov, 2010 polyclonal
Rabbit
(serum)
DB, ELISA, IH, WB Human immunogen = soluble Amyloid oligomers generic epitope common to prefibrillar oligomers and not fibrils, monomers or natively folded precursor proteins. Stains small focal or punctuate deposits in AD tissue does not stain diffuse plaques or other plaque types. Stains Aβ and polyQ prefibrillar oligomers. -
Amyloid-β, APP, APLP, AICD From manufacturers (1)
BioLegend monoclonal
IgG2b
Mouse
(biotinylated IgG, PBS, no preservatives or carrier proteins)
ELISA, IH, IP, WB Human, Mouse the epitope lies within amino acids 18-22 of beta amyloid (VFFAE) reactive to aa 17-24 Aβ and to APP -
CD45 From manufacturers (1)
Abcam monoclonal
IgG1
Mouse
(liquid, PBS, azide, protein A purified; conj. FITC)
FC Human immunogen = non-T, non-B CALLA positive, ALL cell line REH recognizes the CD45 leukocyte common antigen (LCA) family -
Cytokines & Receptors From labs (1)
Unknown
Cat# NA
monoclonal
IgG2b
Rat
IH Mouse immunogen = N-terminal mouse CCR2 binds to CCR2; does not cross-react with murine CCR5 or human CCR2 and CCR5 -
DJ-1 From manufacturers (1)
BioLegend monoclonal
IgM
Mouse
(Purified, PBS, no carrier or preservative)
ELISA, WB Human, Zebra fish - recognises a fusion protein of GST/DJ-1 but not GST alone; also recognises a FLAG-tagged DJ-1 expressed in eukaryotic cells Available from BioLegend
Mitochondrial Proteins From manufacturers (1)
BioLegend monoclonal
IgG1Λ
Mouse
(precipitated and dialyzed supernate, PBS, azide, no BSA)
DB, ELISA, IC, IF, IH, WB Human immunogen = recombinant, full-length human ERAB protein (GST fused) endogenous ERAB in extracts from cells, esp. mitochondria; virtually no crossreactivity to other human proteins Available from BioLegend
Tau From labs (12)
Formerly available through Dr. Peter Davies. For updated information, contact antibodies@alzforum.org. monoclonal
IgG2b
Mouse
- Human, Mouse, Rat epitope around phospho Threonine 231 tau phospho. at Thr231 -
Formerly available through Dr. Peter Davies. For updated information, contact antibodies@alzforum.org. monoclonal
IgG1
Mouse
- Human, Mouse conformation dependent antibody (epitope within aa 312-322) reactivity depends on both the N terminus (amino acids 7–9), and an amino acid sequence of tau (amino acids 313–322) in the third microtubule binding domain. Recognizes neurofibrillary tangles but does not react with FAC1 -
Formerly available through Dr. Peter Davies. For updated information, contact antibodies@alzforum.org. monoclonal
IgG2b
Mouse
- Human, Mouse - tau -
Formerly available through Dr. Peter Davies. For updated information, contact antibodies@alzforum.org. monoclonal
Mouse
- Human, Mouse immunogen = amino acids around phosphorylated Ser214 recognizes human and murine tau phosphorylated at S214 -
Formerly available through Dr. Peter Davies. For updated information, contact antibodies@alzforum.org. monoclonal
IgG3
Mouse
- Human, Mouse immunogen = the synthetic phosphopeptides KSPRHLS(P)NV S(P)STGS(P)ID and KSPRHLS(P)NV SS(P)TGSID recognizes the PKA-dependent phosphorylation of ser409 in tau; immunoreactivity with neurofibrillary pathology in both early and advanced Alzheimer’s disease, but not in normal brain tissue; reacts with only PHF and the tau peptide containing phospho ser409 -
Formerly available through Dr. Peter Davies. For updated information, contact antibodies@alzforum.org. monoclonal
Mouse
- Human, Mouse epitope around phospho Threonine 231 highly specific for tau phospho. at Thr231 -
Formerly available through Dr. Peter Davies. For updated information, contact antibodies@alzforum.org. monoclonal
IgG1
Mouse
- Human, Mouse epitope at aa102–140 recognizes total tau -
Formerly available through Dr. Peter Davies. For updated information, contact antibodies@alzforum.org. monoclonal
IgG2b
Mouse
- Human epitope around phospho-serine 202 Detects tau phosphorylated at serine-202. -
Formerly available through Dr. Peter Davies. For updated information, contact antibodies@alzforum.org. monoclonal
IgM
Mouse
(IC, IF, IH, IP, WB)
- Human Tau phosphorylated at threonine-231; also conformation-sensitive. Tau phosphorylated at threonine-231; also conformation-sensitive. Not reactive to normal tau. The TG3 epitope is expressed in mitotic cells but not in quiescent cells, suggesting that mitotic phosphoepitopes may lead to conformational changes. -
Formerly available through Dr. Peter Davies. For updated information, contact antibodies@alzforum.org. monoclonal
IgM
Mouse
- - Raised against human basal forebrain homogenate. Epitope subsequently determined to include amino acids 2-10 and 312-342 of tau. Recognizes a misfolded conformation of tau. 68 kDa Tau. Stains neuronal components of AD brain specimens but not normal brain specimens. -
Formerly available through Dr. Peter Davies. For updated information, contact antibodies@alzforum.org. monoclonal
IgG1
Mouse
- Human Immunogen: paired helical filaments of tau. Epitope: around serine-396 and serine-404 phosphorylated sites. - -
Formerly available through Dr. Peter Davies. For updated information, contact antibodies@alzforum.org. monoclonal
IgG2b
Mouse
- Human Human tau 130-150 - -
Tau From manufacturers (8)
Autogen Bioclear monoclonal
IgG1
Mouse
(liquid, sterile filtered, PBS, no preservative)
ELISA, IH, WB Human immunogen = human PHF tau, aa. around phosphorylated Thr 212 and Ser 214 tau phospho. at Thr 212 and Ser 214; no cross with normal tau -
- monoclonal
IgG1
Mouse
(liquid, sterile filtered, PBS, no preservative)
ELISA, IH, WB Human immunogen = human PHF tau, aa. around phosphorylated Thr 212 and Ser 214 tau phospho. at Thr 212 and Ser 214; no cross with normal tau -
Autogen Bioclear monoclonal
IgG1
Mouse
(liquid, sterile filtered, PBS, no preservative, biotin)
ELISA, IH, WB Human immunogen = human PHF tau, aa. around phosphorylated Thr 212 and Ser 214 tau phospho. at Thr 212 and Ser 214; no cross with normal tau -
Pierce Thermo Scientific monoclonal
IgG1κ
Mouse
(biotin, no carrier or preservative)
ELISA, IH Human around phosphorylated Thr212 and Ser214 PHF tau with phosphorylated Thr212 and Ser214, not normal tau, or biopsy, autopsy or fetal tau. -
Pierce Thermo Scientific monoclonal
IgG1κ
Mouse
(purified, no carrier or preservative)
ELISA, IH, WB Human immunogen = tau around phosphorylated Thr212 and Ser214 PHF tau with phosphorylated Thr212 and Ser214, not normal tau, or biopsy, autopsy or fetal tau. -
None monoclonal
IgG1
Mouse
(liquid, semipurified Ig, serum-free , DMEM, thimerosal)
IF, IH, WB Human immunogen = Alzheimer tau isolated from AD brain (minimal epitope aa 321-391) recognizes Alzheimer tau, shows no cross-reactivity with MAPs or tubulin. Does not react with tau from age- matched control brains or with six recomb. tau isoforms -
- monoclonal
IgG1κ
Mouse
(liquid, PBS, sterile filtered, affinity purified)
ELISA, IH, WB Human partially purified human tau, aa. around phosphorylated Serine 202 Recognizes phosphorylated paired helical filament tau. Recognises tau protein phosphorylated at both serine 202 and threonine 205. No cross-reactivity with unphoshorylated tau. -
Pierce Thermo Scientific monoclonal
IgG1κ
Mouse
(serum-free supernatant, affinity purified, no carrier or preservative. Also available Biotin conj, MN-1000B)
ELISA, IH, WB Bovine, Human immunogen = purified human tau, between aa 159 and 163, (PPGQK) tau and PHF tau from human and bovine brain -
Tubulin From manufacturers (1)
None monoclonal
IgG2a
Mouse
(liquid, PBS, thimerosal, protein A purified)
WB Mammal (various) immunogen = peptide sequence C G E E E G E detyrosinated α- Tubulin Discontinued
γ-secretase/ Presenilins From manufacturers (1)
BioLegend polyclonal
Rabbit
(liquid, affinity purified)
IH, WB Human immunogen = human Aph-1aL/ C-terminal region sequence C R R Q E D S R V M V Y S A L R I P P E D Aph-1aL Available from BioLegend