Antibody

sAPPβ

Clonality: unknown
Host: Unknown Host
Methods: IB
Source: Ab1A9
(SmithKline Beecham Pharmaceuticals, Harlow, UK)
Reference:
Parkin, 2007
Reactivity:
reference: Parvathy S, Hussain I, et al., Biochemistry 1998, 37, 1680-1685<br /><a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=ShowDetailView&amp;TermToSearch=9484239">paper</a>

Immunogen/Epitope

C-terminus of large ectodomain of APP

Specificity

recognizes the neoepitope formed at the C-terminus of the large ectodomain of APP following β-secretase cleavage. As this neoepitope is cryptic in both full-length APP and sAPPα, Ab1A9 recognizes only sAPPβ

Comments / Questions

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References

Paper Citations

  1. . Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11062-7. PubMed.

External Citations

  1. paper

Further Reading

No Available Further Reading