Host: Unknown Host
(SmithKline Beecham Pharmaceuticals, Harlow, UK)
reference: Parvathy S, Hussain I, et al., Biochemistry 1998, 37, 1680-1685<br /><a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=9484239">paper</a>
C-terminus of large ectodomain of APP
recognizes the neoepitope formed at the C-terminus of the large ectodomain of APP following β-secretase cleavage. As this neoepitope is cryptic in both full-length APP and sAPPα, Ab1A9 recognizes only sAPPβ
- Parkin ET, Watt NT, Hussain I, Eckman EA, Eckman CB, Manson JC, Baybutt HN, Turner AJ, Hooper NM. Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11062-7. PubMed.
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