Antibody

PS-1 NT

Clonality: polyclonal
Host: Rabbit
Methods: WB
Source: PS1NT
(Gopal Thinakaran, Department of Neurobiology, University of Chicago)
References:
Veeraraghavalu, 2010
O'Connor, 2008
Ikeuchi, 2003
Reactivity:
reference: <a href="http://www.sciencedirect.com/science?_ob=MImg&amp;_imagekey=B6WSS-41838X3-M-1&amp;_cdi=7054&amp;_user=10&amp;_pii=S0896627300802913&amp;_coverDate=07%2F31%2F1996&amp;_sk=%23TOC%237054%231996%23999829998%23575399%23FLA%23display%23Volume_17,_Issue_1,_Pages_1-192_%28July_1996%29%23tagged%23Volume%23first%3D17%23Issue%23first%3D1%23date%23%28July_1996%29%23&amp;view=c&amp;_gw=y&amp;wchp=dGLbVzb-zSkWA&amp;md5=9d1eb94a660d8463a11102f283974603&amp;ie=/sdarticle.pdf" target="_new">Thinakaran G., et al.</a>, Neuron 1996 Jul; 17(1):181-90

Immunogen/Epitope

(epitope contains residues 1–65 of the N-terminus of PS1)

Specificity

full-length PS1 and NH2-terminal fragment of PS1

Comments / Questions

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References

Paper Citations

  1. . Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling. J Neurosci. 2010 May 19;30(20):6903-15. PubMed.
  2. . Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 2008 Dec 26;60(6):988-1009. PubMed.
  3. . The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage. J Biol Chem. 2003 Mar 7;278(10):7751-4. Epub 2003 Jan 24 PubMed.

External Citations

  1. Gopal Thinakaran
  2. Thinakaran G., et al.

Further Reading

No Available Further Reading