Antibody

PS-1 loop

Clonality: polyclonal
Host: Rabbit
Methods: IH
Source: anti-αPS1 Loop
(Gopal Thinakaran, Department of Neurobiology, University of Chicago)
References:
Veeraraghavalu, 2010
Yu, 2001
Luo, 2003
Reactivity:
Reacts in: Human, Mouse
reference: <a href="http://www.jbc.org/content/272/45/28415.full" target="_new">Thinakaran G., et al.</a>, J Biol Chem 272:28415-28422, l997

Immunogen/Epitope

immunogen = aa 320-375 of human PS1

Specificity

reacts with epitopes in the hydrophilic loop domain (amino acids 263–407) of human and mouse PS1; no cross reactivity of PS1Loop antiserum with the human PS2 fusion protein

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References

Paper Citations

  1. . Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling. J Neurosci. 2010 May 19;30(20):6903-15. PubMed.
  2. . APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron. 2001 Sep 13;31(5):713-26. PubMed.
  3. . PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. J Biol Chem. 2003 Mar 7;278(10):7850-4. Epub 2003 Jan 8 PubMed.

External Citations

  1. Gopal Thinakaran
  2. Thinakaran G., et al.

Further Reading

No Available Further Reading