Antibody

PrPSc (15B3)

Clonality: monoclonal
Host: Mouse
Isotype: IgM
Methods: IP, WB
Source: Reference:
Dossena, 2008
(provided by Alex Raeber and Bruno Oesch, Prionics, Zurich)
Reactivity:
Reacts in: Bovine, Human, Mouse
Reference: <br /><a href="http://www.ncbi.nlm.nih.gov/pubmed/9363892?dopt=Abstract&amp;holding=npg" target="_new">Korth, et al., 1997</a>

Immunogen/Epitope

(three polypeptide segments responsible for the 15B3 epitope: 15b3-1 involves residues 142-148 GSDYEDR(YY); 15b3-2 residues 162-170 YYRPVDQYS;15b3-3 residues 214-226 CITQYQ RESQAYY)

Specificity

recognizes both protease resistant and protease sensitive forms of abnormal, disease associated PrP

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References

Paper Citations

  1. . Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model. Neuron. 2008 Nov 26;60(4):598-609. PubMed.

External Citations

  1. Korth, et al., 1997

Further Reading

No Available Further Reading