Antibody

prion protein (6H4)

Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: ELISA, IH, WB
Source: Cat# 01-010, 01-011
Reference:
Parkin, 2007
Formulation: liquid, serum-free medium, azide
Reactivity:
Reacts in: Mammal (various), Human

Immunogen/Epitope

The epitope falls within amino acids 144-152, (DYEDRYYRE) of human prion protein

Specificity

mAB 6H4 recognizes the sequence DYEDRYYRE in the prion protein; reacts on Western blots with mouse and hamster PrP, indicating that the substitution at position 145 does not prevent binding of 6H4

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References

Paper Citations

  1. . Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11062-7. PubMed.

Further Reading

No Available Further Reading