Antibody

Presenilin-1, loop (PS1-loop)

Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: IC, IH, IP, WB
Source: Chemicon and Upstate are Millipore
Cat# MAB5232
References:
Tian Y, 2010
Wakabayashi, 2009
Serneels, 2009
Breunig, 2007
Tu, 2006
Deng, 2006
Runz, 2002
Formulation: liquid, ascites, no preservative
Reactivity:
Reacts in: Primate (various), Mouse, Rat

Immunogen/Epitope

immunogen = Presenilin-1, loop fusion protein, C-terminal (amino acids 263-378), human

Specificity

Presenilin-1, loop.

Comments / Questions

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References

Paper Citations

  1. . An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production. Nat Struct Mol Biol. 2010 Feb;17(2):151-8. PubMed.
  2. . Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains. Nat Cell Biol. 2009 Nov;11(11):1340-6. PubMed.
  3. . gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science. 2009 May 1;324(5927):639-42. Epub 2009 Mar 19 PubMed.
  4. . Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20558-63. PubMed.
  5. . Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell. 2006 Sep 8;126(5):981-93. PubMed.
  6. . Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. J Neurosci. 2006 Apr 5;26(14):3845-54. PubMed.
  7. . Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells. J Neurosci. 2002 Mar 1;22(5):1679-89. PubMed.

Further Reading

No Available Further Reading